Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance
Por:
Martinez-Balibrea, E, Martinez-Cardus, A, Gines, A, de Porras, VR, Moutinho, C, Layos, L, Manzano, JL, Buges, C, Bystrup, S, Esteller, M and Abad, A
Publicada:
1 ago 2015
Resumen:
Oxaliplatin was the first platinum drug with proven activity against colorectal tumors, becoming a standard in the management of this malignancy. It is also considered for the treatment of pancreatic and gastric cancers. However, a major reason for treatment failure still is the existence of tumor intrinsic or acquired resistance. Consequently, it is important to understand the molecular mechanisms underlying the appearance of this phenomenon to find ways of circumventing it and to improve and optimize treatments. This review will be focused on recent discoveries about oxaliplatin tumor-related resistance mechanisms, including alterations in transport, detoxification, DNA damage response and repair, cell death (apoptotic and nonapoptotic), and epigenetic mechanisms.
Filiaciones:
:
Hosp Badalona Germans Trias & Pujol, Med Oncol Serv, ICO, Barcelona 08916, Spain
Inst Germans Trias & Pujol Fdn IGTP, Hlth Sci Res Inst, Badalona, Catalonia, Spain
Martinez-Cardus, A:
Bellvitge Biomed Res Inst IDIBELL, PEBC, Barcelona, Catalonia, Spain
Gines, A:
Inst Germans Trias & Pujol Fdn IGTP, Hlth Sci Res Inst, Badalona, Catalonia, Spain
:
Inst Germans Trias & Pujol Fdn IGTP, Hlth Sci Res Inst, Badalona, Catalonia, Spain
Moutinho, C:
Bellvitge Biomed Res Inst IDIBELL, PEBC, Barcelona, Catalonia, Spain
:
Hosp Badalona Germans Trias & Pujol, Med Oncol Serv, ICO, Barcelona 08916, Spain
:
Hosp Badalona Germans Trias & Pujol, Med Oncol Serv, ICO, Barcelona 08916, Spain
:
Inst Germans Trias & Pujol Fdn IGTP, Hlth Sci Res Inst, Badalona, Catalonia, Spain
Esteller, M:
Bellvitge Biomed Res Inst IDIBELL, PEBC, Barcelona, Catalonia, Spain
Univ Barcelona, Sch Med, Dept Physiol Sci 2, Barcelona, Catalonia, Spain
ICREA, Barcelona, Catalonia, Spain
Abad, A:
Hosp Badalona Germans Trias & Pujol, Med Oncol Serv, ICO, Barcelona 08916, Spain
Inst Germans Trias & Pujol Fdn IGTP, Hlth Sci Res Inst, Badalona, Catalonia, Spain
Hosp CIMA Sanitas, Oncol Unit, Barcelona, Catalonia, Spain
|