Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol
Por:
Rodriguez-Morato, J, Boronat, A, Kotronoulas, A, Pujadas, M, Pastor, A, Olesti, E, Perez-Mana, C, Khymenets, O, Fito, M, Farre, M and de la Torre, R
Publicada:
1 may 2016
Resumen:
Hydroxytyrosol and tyrosol are dietary phenolic compounds present in virgin olive oil and wine. Both compounds are also endogenously synthesized in our body as byproducts of dopamine and tyramine metabolisms, respectively. Over the last decades, research into hydroxytyrosol and tyrosol has experienced an increasing interest due to the role that these compounds may play in the prevention of certain pathologies (e.g. cardiovascular, metabolic, neurodegenerative diseases and cancer). The translation of promising in vitro and in vivo biological effects from preclinical studies to the context of human disease prevention initially depends on whether the dose ingested becomes available at the site of action. In this regard, information regarding the bioavailability and metabolic disposition of hydroxytyrosol and tyrosol is of most importance to evaluate the impact they may have on human health. In this review, we discuss and summarize the state of the art of the scientific evidence regarding the processes of absorption, distribution, metabolism and excretion of both hydroxytyrosol and tyrosol. We also examine the impact of these compounds and their metabolites on biological activity in terms of beneficial health effects. Finally, we evaluate the different analytical approaches that have been developed to measure the plasma and urinary levels of hydroxytyrosol, tyrosol and their metabolites.
Filiaciones:
Rodriguez-Morato, J:
IMIM Hosp Del Mar Res Inst, Integrat Pharmacol & Syst Neurosci, Barcelona, Spain
Univ Pompeu Fabra CEXS UPF, Dept Expt & Hlth Sci, Barcelona, Spain
CIBER Fisiopatol Obesidad & Nutr, Santiago De Compostela, Spain
Boronat, A:
IMIM Hosp Del Mar Res Inst, Integrat Pharmacol & Syst Neurosci, Barcelona, Spain
Univ Pompeu Fabra CEXS UPF, Dept Expt & Hlth Sci, Barcelona, Spain
Kotronoulas, A:
IMIM Hosp Del Mar Res Inst, Integrat Pharmacol & Syst Neurosci, Barcelona, Spain
Pujadas, M:
IMIM Hosp Del Mar Res Inst, Integrat Pharmacol & Syst Neurosci, Barcelona, Spain
Pastor, A:
IMIM Hosp Del Mar Res Inst, Integrat Pharmacol & Syst Neurosci, Barcelona, Spain
CIBER Fisiopatol Obesidad & Nutr, Santiago De Compostela, Spain
Olesti, E:
IMIM Hosp Del Mar Res Inst, Integrat Pharmacol & Syst Neurosci, Barcelona, Spain
Univ Pompeu Fabra CEXS UPF, Dept Expt & Hlth Sci, Barcelona, Spain
Perez-Mana, C:
IMIM Hosp Del Mar Res Inst, Integrat Pharmacol & Syst Neurosci, Barcelona, Spain
Autonomous Univ Barcelona, Dept Pharmacol Therapeut & Toxicol, Cerdanyola Del Valles, Spain
Khymenets, O:
IMIM Hosp Del Mar Res Inst, Integrat Pharmacol & Syst Neurosci, Barcelona, Spain
Fito, M:
CIBER Fisiopatol Obesidad & Nutr, Santiago De Compostela, Spain
IMIM Hosp Del Mar Res Inst, Cardiovasc Risk & Nutr Res Grp, Barcelona, Spain
:
IMIM Hosp Del Mar Res Inst, Integrat Pharmacol & Syst Neurosci, Barcelona, Spain
Autonomous Univ Barcelona, Dept Pharmacol Therapeut & Toxicol, Cerdanyola Del Valles, Spain
Hosp Univ Germans Trias & Pujol IGTP, Badalona, Spain
de la Torre, R:
IMIM Hosp Del Mar Res Inst, Integrat Pharmacol & Syst Neurosci, Barcelona, Spain
Univ Pompeu Fabra CEXS UPF, Dept Expt & Hlth Sci, Barcelona, Spain
CIBER Fisiopatol Obesidad & Nutr, Santiago De Compostela, Spain
Green Accepted
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