Preanalytical issues related to routine and diagnostic glucose tests: Results from a survey in Spain
Por:
Garcia-del-Pino, I, Bauca, JM, Gomez, C, Caballero, A, Llopis, MA, Ibarz, M, Martinez, D, Ventura, M, Marzana, I, Puente, JJ, Segovia, M, Salas, P and Gomez-Rioja, R
Publicada:
1 feb 2020
Ahead of Print:
15 dic 2019
Resumen:
Introduction: Diabetes mellitus (DM) is one of the most prevalent diseases worldwide. The objective of this study was to find out under what pre-analytical conditions routine and diagnostic glucose tests are performed across Spanish laboratories; and also what criteria are used for DM diagnosis.
Materials and methods: An online survey was performed by the Commission on Quality Assurance in the Extra-Analytical Phase of the Spanish Society of Laboratory Medicine (SEQC-ML). Access to the questionnaire was available on the home page of the SEQC-ML website during the period April-July 2018. Data analysis was conducted with the IBM SPSS (c) Statistics (version 20.0) program.
Results: A total of 96 valid surveys were obtained. Most laboratories were in public ownership, serving hospital and primary care patients, with high and medium workloads, and a predominance of mixed routine-urgent glucose testing. Serum tubes were the most used for routine glucose analysis (92%) and DM diagnosis (54%); followed by lithium-heparin plasma tubes (62%), intended primarily for urgent glucose testing; point-ofcare testing devices were used by 37%; and plasma tubes with a glycolysis inhibitor, mainly sodium fluoride, by 19%. Laboratories used the cut-off values and criteria recognized worldwide for DM diagnosis in adults and glucose-impaired tolerance, but diverged in terms of fasting plasma glucose and gestational DM criteria.
Conclusion: Preanalytical processing of routine and DM diagnostic glucose testing in Spain does not allow a significant, non-quantified influence of glycolysis on the results to be ruled out. Possible adverse consequences include a delay in diagnosis and possible under-treatment.
Filiaciones:
Garcia-del-Pino, I:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
A Coruna Univ Hosp Complex, Area Lab, La Coruna, Spain
Bauca, JM:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
Son Espases Univ Hosp, Dept Lab Med, Palma De Mallorca, Balearic Island, Spain
:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
Germans Trias & Pujol Hosp, Dept Clin Anal & Biochem, Lab Clin Metropolitana Nord, Badalona, Spain
Caballero, A:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
Vall dHebron Hosp, Dept Clin Biochem, Preanalyt Area, Barcelona, Spain
Llopis, MA:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
Catalan Hlth Inst, Clin Labs Corp Coordinat, Barcelona, Spain
Ibarz, M:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
Arnau de Vilanova Univ Hosp, Dept Lab Med, IRBLleida, Lleida, Spain
Martinez, D:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
Univ Navarra Clin, Dept Lab Med, Madrid, Spain
Ventura, M:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
Spanish Soc Lab Med, External Qual Assurance Programmes, Barcelona, Spain
Marzana, I:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
Cruces Univ Hosp, Dept Lab, Baracaldo, Bizkaia, Spain
Puente, JJ:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
Lozano Blesa Univ Clin Hosp, Dept Biochem, Zaragoza, Spain
Segovia, M:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
La Paz Cantoblanco Carlos III Univ Hosp, Dept Lab Med, Madrid, Spain
Salas, P:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
Catlab, Preanalyt & Extraanalyt Qual Phase, Barcelona, Spain
Gomez-Rioja, R:
Extra Analyt Qual Commiss, Spanish Soc Lab Med, Barcelona, Spain
La Paz Cantoblanco Carlos III Univ Hosp, Dept Lab Med, Madrid, Spain
Green Submitted, Green Published, gold
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