Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer


Por: Hellmann, MD, Paz-Ares, L, Caro, RB, Zurawski, B, Kim, SW, Costa, EC, Park, K, Alexandru, A, Lupinacci, L, Jimenez, ED, Sakai, H, Albert, I, Vergnenegre, A, Peters, S, Syrigos, K, Barlesi, F, Reck, M, Borghaei, H, Brahmer, JR, O'Byrne, KJ, Geese, WJ, Bhagavatheeswaran, P, Rabindran, SK, Kasinathan, RS, Nathan, FE and Ramalingam, SS

Publicada: 21 nov 2019 Ahead of Print: 28 sep 2019
Categoría: Medicine (miscellaneous)

Resumen:
BACKGROUND In an early-phase study involving patients with advanced non-small-cell lung cancer (NSCLC), the response rate was better with nivolumab plus ipilimumab than with nivolumab monotherapy, particularly among patients with tumors that expressed programmed death ligand 1 (PD-L1). Data are needed to assess the long-term benefit of nivolumab plus ipilimumab in patients with NSCLC. METHODS In this open-label, phase 3 trial, we randomly assigned patients with stage IV or recurrent NSCLC and a PD-L1 expression level of 1% or more in a 1:1:1 ratio to receive nivolumab plus ipilimumab, nivolumab alone, or chemotherapy. The patients who had a PD-L1 expression level of less than 1% were randomly assigned in a 1:1:1 ratio to receive nivolumab plus ipilimumab, nivolumab plus chemotherapy, or chemotherapy alone. All the patients had received no previous chemotherapy. The primary end point reported here was overall survival with nivolumab plus ipilimumab as compared with chemotherapy in patients with a PD-L1 expression level of 1% or more. RESULTS Among the patients with a PD-L1 expression level of 1% or more, the median duration of overall survival was 17.1 months (95% confidence interval [CI], 15.0 to 20.1) with nivolumab plus ipilimumab and 14.9 months (95% CI, 12.7 to 16.7) with chemotherapy (P=0.007), with 2-year overall survival rates of 40.0% and 32.8%, respectively. The median duration of response was 23.2 months with nivolumab plus ipilimumab and 6.2 months with chemotherapy. The overall survival benefit was also observed in patients with a PD-L1 expression level of less than 1%, with a median duration of 17.2 months (95% CI, 12.8 to 22.0) with nivolumab plus ipilimumab and 12.2 months (95% CI, 9.2 to 14.3) with chemotherapy. Among all the patients in the trial, the median duration of overall survival was 17.1 months (95% CI, 15.2 to 19.9) with nivolumab plus ipilimumab and 13.9 months (95% CI, 12.2 to 15.1) with chemotherapy. The percentage of patients with grade 3 or 4 treatment-related adverse events in the overall population was 32.8% with nivolumab plus ipilimumab and 36.0% with chemotherapy. CONCLUSIONS First-line treatment with nivolumab plus ipilimumab resulted in a longer duration of overall survival than did chemotherapy in patients with NSCLC, independent of the PD-L1 expression level. No new safety concerns emerged with longer follow-up.

Filiaciones:
Hellmann, MD:
 Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

Paz-Ares, L:
 Univ Complutense, Ctr Nacl Invest Oncol, Hosp Univ Doce Octubre, Madrid, Spain

 Ctr Invest Biomed Red Canc, Madrid, Spain

Caro, RB:
 Hosp Univ Virgen del Rocio, Seville, Spain

Zurawski, B:
 Ambulatorium Chemioterapii, Bydgoszcz, Poland

Kim, SW:
 Asan Med Ctr, Seoul, South Korea

:
 Germans Trias & Pujol Hosp, Catalan Inst Oncol, Badalona, Spain

Park, K:
 Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea

Alexandru, A:
 Inst Oncol Prof Dr Alexandru Trestioreanu, Bucharest, Romania

Lupinacci, L:
 Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina

Jimenez, ED:
 Inst Jalisciense Cancerol, Guadalajara, Jalisco, Mexico

Sakai, H:
 Saitama Canc Ctr, Saitama, Japan

Albert, I:
 Matrai Gyogyint, Matrahaza, Hungary

Vergnenegre, A:
 Limoges Univ Hosp, Limoges, France

Peters, S:
 Lausanne Univ, CHU Vaudois, Lausanne, Switzerland

Syrigos, K:
 Univ Athens, Sotiria Gen Hosp, Athens, Greece

Barlesi, F:
 Aix Marseille Univ, AP HM, INSERM, Natl Ctr Sci Res,Ctr Rech Cancerol Marseillen, Marseille, France

Reck, M:
 German Ctr Lung Res, Airway Res Ctr North, Lung Clin Grosshansdorf, Grosshansdorf, Germany

Borghaei, H:
 Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA

Brahmer, JR:
 Johns Hopkins Kimmel Canc Ctr, Baltimore, MD USA

O'Byrne, KJ:
 Princess Alexandra Hosp, Brisbane, Qld, Australia

Geese, WJ:
 Bristol Myers Squibb, Princeton, NJ USA

Bhagavatheeswaran, P:
 Bristol Myers Squibb, Princeton, NJ USA

Rabindran, SK:
 Bristol Myers Squibb, Princeton, NJ USA

Kasinathan, RS:
 Bristol Myers Squibb, Princeton, NJ USA

Nathan, FE:
 Bristol Myers Squibb, Princeton, NJ USA

Ramalingam, SS:
 Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA
ISSN: 00284793





New England Journal of Medicine
Editorial
Massachusetts Medical Society, WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 381 Número: 21
Páginas: 2020-2031
WOS Id: 000505218800006
ID de PubMed: 31562796
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