Serial testing of health care workers for tuberculosis infection: A prospective cohort study.
Por:
Casas I, Esteve M, Guerola R, Latorre I, Villar-Hernández R, Mena G, Prat-Aymerich C, Matllo J and Dominguez J
Publicada:
17 jul 2020
Ahead of Print:
17 jul 2020
Resumen:
Health Care Workers (HCW) may have an occupational risk of latent tuberculosis infection (LTBI) and TB disease. The objective of this study was to evaluate the performance of the 2-step strategy: tuberculin skin test (TST) followed by confirmation with Interferon (IFN)-?- release assays (IGRAs) in HCW. A secondary objective was to determine the factors related to conversions and reversions. HCW at risk of occupational exposure who attended the Occupational Department of the Hospital Germans Trias i Pujol were included during the study period (2013-2016). All professionals testing negative for LTBI were included in a cohort study. These workers were followed up with the administration of a TST and an IGRA quantification at least one year after inclusion in the study. Workers with positive TST, regardless of the results of the IGRA tests, were followed-up with an IGRA. 255 workers were enrolled in the study and 108 workers from the same cohort were followed up. During the follow-up period, seven workers presented TST test conversion. One of these conversions was also confirmed by an IGRA test. There were 2 conversions of cases only testing positive with the IGRA. There have been only 2 reversions of cases testing negative with the IGRA. In this study, not all TST conversions were confirmed when using the IGRA test, which highlights the importance of the 2-step strategy. We have detected a low number of conversions and reversions. Our conclusions should be confirmed in studies with a longer follow-up time.
Filiaciones:
:
Servei de Medicina Preventiva, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Universitat Autònoma de Barcelona, Barcelona, Spain
Esteve M:
Servei de Medicina Preventiva, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Universitat Autònoma de Barcelona, Barcelona, Spain
Guerola R:
Servei de Medicina Preventiva, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Latorre I:
Universitat Autònoma de Barcelona, Barcelona, Spain
Servei de Microbiología, Hospital Universitari Germans Trias i Pujol, Institut d'Investigació Germans Trias i Pujol, Barcelona, Spain
CIBER Enfermedades Respiratorias, CIBERES, Instituto de Salud Carlos III, Madrid, Spain
:
Universitat Autònoma de Barcelona, Barcelona, Spain
Servei de Microbiología, Hospital Universitari Germans Trias i Pujol, Institut d'Investigació Germans Trias i Pujol, Barcelona, Spain
CIBER Enfermedades Respiratorias, CIBERES, Instituto de Salud Carlos III, Madrid, Spain
:
Servei de Medicina Preventiva, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Universitat Autònoma de Barcelona, Barcelona, Spain
:
Universitat Autònoma de Barcelona, Barcelona, Spain
Servei de Microbiología, Hospital Universitari Germans Trias i Pujol, Institut d'Investigació Germans Trias i Pujol, Barcelona, Spain
CIBER Enfermedades Respiratorias, CIBERES, Instituto de Salud Carlos III, Madrid, Spain
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
Matllo J:
Unitat de Salut Laboral, Hospital Universitari Germans Trias i Pujol, Institut Català de la Salut, Barcelona, Spain
:
Universitat Autònoma de Barcelona, Barcelona, Spain
Servei de Microbiología, Hospital Universitari Germans Trias i Pujol, Institut d'Investigació Germans Trias i Pujol, Barcelona, Spain
CIBER Enfermedades Respiratorias, CIBERES, Instituto de Salud Carlos III, Madrid, Spain
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