Intrinsic functional brain connectivity changes following aerobic exercise, computerized cognitive training, and their combination in physically inactive healthy late-middle-aged adults: the Projecte Moviment
Por:
Dimitriadis, SI, Castells-Sánchez, A, Roig-Coll, F, Dacosta-Aguayo, R, Lamonja-Vicente, N, Torán-Monserrat, P, García-Molina, A, Monte-Rubio, G, Stillman, C, Perera-Lluna, A and Mataró, M
Publicada:
1 feb 2024
Ahead of Print:
1 oct 2023
Resumen:
Lifestyle interventions have positive neuroprotective effects in aging. However, there are still open questions about how changes in resting-state functional connectivity (rsFC) contribute to cognitive improvements. The Projecte Moviment is a 12-week randomized controlled trial of a multimodal data acquisition protocol that investigated the effects of aerobic exercise (AE), computerized cognitive training (CCT), and their combination (COMB). An initial list of 109 participants was recruited from which a total of 82 participants (62% female; age = 58.38 +/- 5.47) finished the intervention with a level of adherence > 80%. Only in the COMB group, we revealed an extended network of 33 connections that involved an increased and decreased rsFC within and between the aDMN/pDMN and a reduced rsFC between the bilateral supplementary motor areas and the right thalamus. No global and especially local rsFC changes due to any intervention mediated the cognitive benefits detected in the AE and COMB groups. Projecte Moviment provides evidence of the clinical relevance of lifestyle interventions and the potential benefits when combining them.
Filiaciones:
Dimitriadis, SI:
Univ Barcelona, Dept Clin Psychol & Psychobiol, Passeig Vall dHebron 171, Barcelona 08035, Spain
Univ Barcelona, Inst Neurociencies, Barcelona, Spain
Castells-Sánchez, A:
Univ Barcelona, Dept Clin Psychol & Psychobiol, Passeig Vall dHebron 171, Barcelona 08035, Spain
Univ Barcelona, Inst Neurociencies, Barcelona, Spain
Roig-Coll, F:
Univ Barcelona, Dept Clin Psychol & Psychobiol, Passeig Vall dHebron 171, Barcelona 08035, Spain
Univ Barcelona, Inst Neurociencies, Barcelona, Spain
:
Univ Barcelona, Dept Clin Psychol & Psychobiol, Passeig Vall dHebron 171, Barcelona 08035, Spain
FundaciO Inst Univ Recerca AtenciO Primaria Salut, Unitat Suport Recerca Metropolitana Nord, Mataro, Spain
Inst Invest Ciencies Salut Germans Trias I Pujol I, Badalona, Spain
Lamonja-Vicente, N:
Univ Barcelona, Dept Clin Psychol & Psychobiol, Passeig Vall dHebron 171, Barcelona 08035, Spain
Univ Barcelona, Inst Neurociencies, Barcelona, Spain
FundaciO Inst Univ Recerca AtenciO Primaria Salut, Unitat Suport Recerca Metropolitana Nord, Mataro, Spain
Inst Recerca St Joan de Deu, Esplugas de Llobregat, Spain
:
FundaciO Inst Univ Recerca AtenciO Primaria Salut, Unitat Suport Recerca Metropolitana Nord, Mataro, Spain
Univ Girona, Dept Med, Girona, Spain
García-Molina, A:
Inst Invest Ciencies Salut Germans Trias I Pujol I, Badalona, Spain
Univ Autonoma Barcelona, Inst Guttmann, Inst Univ Neurorehabil, Badalona, Spain
Monte-Rubio, G:
Germans Trias & Pujol Res Inst IGTP, Ctr Comparat Med & Bioimage CMCiB, Badalona, Spain
Stillman, C:
Univ Pittsburgh, Dept Psychol, Pittsburgh, PA USA
Perera-Lluna, A:
Univ Politecn Cataluna, Dept Engn Sistemes, CIBER BBN, Automat & Informat Ind,B2SLab, Barcelona 08028, Spain
Inst Recerca Pediat Hosp St Joan de Deu, Dept Biomed Engn, Barcelona 08950, Spain
Mataró, M:
Univ Barcelona, Dept Clin Psychol & Psychobiol, Passeig Vall dHebron 171, Barcelona 08035, Spain
Univ Barcelona, Inst Neurociencies, Barcelona, Spain
Inst Recerca St Joan de Deu, Esplugas de Llobregat, Spain
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