Coinfection of a yaws patient with two closely related Treponema pallidum subsp. pertenue strains: A rare event with potential evolutionary implications
Por:
Medappa, M, Pospisilová, P, John, LN, González-Beiras, C, Mitja, O and Smajs, D
Publicada:
1 ago 2024
Ahead of Print:
1 may 2024
Resumen:
The etiological agent of yaws is the spirochete Treponema pallidum (TP) subsp. pertenue (TPE) and infects the children of Papua New Guinea, causing ulcerative skin lesions that impairs normal growth and development. Closely related strains of Treponema pallidum subsp. pertenue, JE11, and TE13 were detected in an ulcer biospecimen derived from a 5-year-old yaws patient. Cloning experiments validated the presence of two distinct but similar genotypes, namely TE13 and JE11, co-occurring within a single host. While coinfection with highly related TPE strains has only limited epidemiological and clinical relevance, this is the first documented coinfection with genetically distinct TP strains in a single patient. Similar coinfections in the past were explained by the existence of over a dozen recombinant loci present in the TP genomes as a result of inter-strain or intersubspecies recombination events following an anticipated scenario of TP coinfection, i.e., uptake of foreign DNA and DNA recombination.
Filiaciones:
Medappa, M:
Masaryk Univ, Fac Med, Dept Biol, Brno, Czech Republic
Pospisilová, P:
Masaryk Univ, Fac Med, Dept Biol, Brno, Czech Republic
John, LN:
Univ Barcelona, Fac Med, Barcelona, Spain
Aopi Ctr, Natl Dept Hlth, Port Moresby, Papua N Guinea
:
Hosp Universitari Germans Trais & Pujol, Fight Infect Dis Fdn, Skin Neglected Trop Dis & Sexually Transmitted Inf, Badalona, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Spain
:
Hosp Universitari Germans Trais & Pujol, Fight Infect Dis Fdn, Skin Neglected Trop Dis & Sexually Transmitted Inf, Badalona, Spain
Smajs, D:
Masaryk Univ, Fac Med, Dept Biol, Brno, Czech Republic
Masaryk Univ, Fac Med, Brno 62500, Czech Republic
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