Single nucleotide polymorphisms in PNPLA3, ADAR-1 and IFIH1 are associated with advanced liver fibrosis in patients co-infected with HIV-1//hepatitis C virus
Por:
Franco, S, Horneros, J, Soldevila, L, Ouchi, D, Galvan-Femenia, I, de Cid, R, Tenesa, M, Bechini, J, Perez, R, Llibre, JM, Clotet, B, Tural, C and Martinez, MA
Publicada:
1 dic 2021
Resumen:
Objective: Nonalcoholic fatty liver disease (NAFLD), insulin resistance and liver fibrosis are prevalent in individuals co-infected with HIV type 1 (HIV-1)/hepatitis C virus (HCV), even after HCV eradication. Our aim was to evaluate single nucleotide polymorphisms (SNPs) associated with advanced liver fibrosis in HIV-1/HCV co-infected patients. Design/methods: In a cohort of 102 participants, we genotyped 16 SNPs in 10 genes previously associated with NAFLD and the innate immune response and correlated the genotypes with liver fibrosis and fat accumulation. Results: Multinomial logistic regression analysis identified three metabolic parameters that were significantly associated with advanced liver fibrosis (stage F3-F4): albumin [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.69-0.91, P = 0.001], percentage of visceral fat area (PVFA) (OR 1.06, 95% CI 1.01-1.12, P = 0.03) and BMI (OR 1.47, 95% CI 1.22-1.77, P < 0.0001). After adjustment for sex, albumin, PVFA and BMI, we found that three SNPs were significantly associated with advanced fibrosis, one each in PNPLA3/rs738409 (P = 0.016), ADAR-1/rs1127313 (P = 0.029) and IFIH1/rs1990760 (P = 0.033). Conclusion: Our results indicate that genotyping for these SNPs can be a useful predictive tool for liver fibrosis progression and liver fat accumulation in patients co-infected with HIV-1/HCV.
Filiaciones:
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Univ Autonoma Barcelona UAB, Hosp Univ Germans Trias & Pujol, IrsiCaixa, Badalona, Spain
Horneros, J:
Univ Autonoma Barcelona UAB, Hosp Univ Germans Trias & Pujol, Radiol Dept, Badalona, Spain
Soldevila, L:
Univ Autonoma Barcelona UAB, Hosp Univ Germans Trias & Pujol, Internal Med Dept, Badalona, Spain
Ouchi, D:
Univ Autonoma Barcelona UAB, Hosp Univ Germans Trias & Pujol, IrsiCaixa, Badalona, Spain
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Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Badalona, Spain
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Hlth Res Inst Germans Trias & Pujol IGTP, Program Predict & Personalized Med Canc PMPPC, Genomes Life GCAT Lab Grp, Badalona, Spain
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Univ Autonoma Barcelona UAB, Hosp Univ Germans Trias & Pujol, Radiol Dept, Badalona, Spain
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Univ Autonoma Barcelona UAB, Hosp Univ Germans Trias & Pujol, Internal Med Dept, Badalona, Spain
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Univ Autonoma Barcelona UAB, Hosp Univ Germans Trias & Pujol, Radiol Dept, Badalona, Spain
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Hosp Badalona Germans Trias & Pujol, Infect Dis Dept, Badalona, Spain
Hosp Badalona Germans Trias & Pujol, Fundacio Lluita SIDA & Malalties Infeccioses, Badalona, Spain
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Univ Autonoma Barcelona UAB, Hosp Univ Germans Trias & Pujol, IrsiCaixa, Badalona, Spain
Hosp Badalona Germans Trias & Pujol, Infect Dis Dept, Badalona, Spain
Hosp Badalona Germans Trias & Pujol, Fundacio Lluita SIDA & Malalties Infeccioses, Badalona, Spain
Univ Vic, Univ Cent Catalunya UVIC UCC, Barcelona, Spain
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Univ Autonoma Barcelona UAB, Hosp Univ Germans Trias & Pujol, Internal Med Dept, Badalona, Spain
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Univ Autonoma Barcelona UAB, Hosp Univ Germans Trias & Pujol, IrsiCaixa, Badalona, Spain
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