Pericytes in the disease spotlight
Por:
van Splunder, H, Villacampa, P, Martínez-Romero, A and Graupera, M
Publicada:
1 ene 2024
Ahead of Print:
1 ene 2024
Resumen:
Pericytes are known as the mural cells in small-caliber vessels that interact closely with the endothelium. Pericytes play a key role in vasculature formation and homeostasis, and when dysfunctional contribute to vasculature-related diseases such as diabetic retinopathy and neurodegenerative conditions. In addition, significant extravascular roles of pathological pericytes are being discovered with relevant implications for cancer and fibrosis. Pericyte research is challenged by the lack of consistent molecular markers and clear discrimination criteria versus other (mural) cells. However, advances in single-cell approaches are uncovering and clarifying mural cell identities, biological functions, and ontogeny across organs. We discuss the latest developments in pericyte pathobiology to inform future research directions and potential outcomes.
Filiaciones:
van Splunder, H:
Josep Carreras Leukemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona 08916, Catalonia, Spain
Villacampa, P:
Univ Barcelona, Fac Med & Hlth Sci, Dept Physiol Sci, Carrer Feixa Llarga S-N, Barcelona 08907, Spain
Bellvitge Biomed Res Inst IDIBELL, Carrer Feixa Llarga S-N, Barcelona 08907, Spain
Martínez-Romero, A:
Josep Carreras Leukemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona 08916, Catalonia, Spain
:
Josep Carreras Leukemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona 08916, Catalonia, Spain
Inst Catalana Invest & Estudios Avanzados ICREA, Passeig Lluis Companys 23, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Ave Monforte de Lemos 5, Madrid 28029, Spain
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