Modifiable lifestyle factors and the risk of post-COVID-19 multisystem sequelae, hospitalization, and death
Por:
Wang, YH, Su, BB, Alcalde-Herraiz, M, Barclay, NL, Tian, YH, Li, CX, Wareham, NJ, Paredes, R, Xie, JQ and Prieto-Alhambra, D
Publicada:
29 jul 2024
Resumen:
Effective prevention strategies for post-COVID complications are crucial for patients, clinicians, and policy makers to mitigate their cumulative burden. This study evaluated the association of modifiable lifestyle factors (smoking, alcohol intake, BMI, physical activity, sedentary time, sleep duration, and dietary habits) with COVID-19 multisystem sequelae, death, and hospitalization in the UK Biobank cohort (n = 68,896). A favorable lifestyle (6-10 healthy factors; 46.4%) was associated with a 36% lower risk of multisystem sequelae (HR, 0.64; 95% CI, 0.58-0.69; ARR at 210 days, 7.08%; 95% CI, 5.98-8.09) compared to an unfavorable lifestyle (0-4 factors; 12.3%). Risk reductions spanned all 10 organ systems, including cardiovascular, coagulation, metabolic, gastrointestinal, kidney, mental health, musculoskeletal, respiratory disorders, and fatigue. This beneficial effect was largely attributable to direct lifestyle impacts independent of corresponding pre-infection comorbidities (71% for any sequelae). A favorable lifestyle was also related to the risk of post-COVID death (HR 0.59, 0.52-0.66) and hospitalization (HR 0.78, 0.73-0.84). These associations persisted across acute and post-acute infection phases, irrespective of hospitalization status, vaccination, or SARS-CoV-2 variant. These findings underscore the clinical and public health importance of adhering to a healthy lifestyle in mitigating long-term COVID-19 adverse impacts and enhancing future pandemic preparedness.
The impact of modifiable lifestyle factors on the risk of post-COVID-19 sequelae is not well understood. Here, the authors perform a prospective cohort study amongst UK Biobank participants and show that a healthy lifestyle is associated with lower risk of post-COVID-19 sequelae across multiple organ systems.
Filiaciones:
Wang, YH:
Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
Su, BB:
Chinese Acad Med Sci & Peking Union Med Coll, Sch Populat Med & Publ Hlth, Beijing, Peoples R China
Alcalde-Herraiz, M:
Univ Oxford, Ctr Stat Med, NDORMS, Oxford, England
Univ Oxford, NIHR Biomed Res Ctr Oxford, NDORMS, Oxford, England
Barclay, NL:
Univ Oxford, Ctr Stat Med, NDORMS, Oxford, England
Univ Oxford, NIHR Biomed Res Ctr Oxford, NDORMS, Oxford, England
Tian, YH:
Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Wuhan, Peoples R China
Li, CX:
Univ Cambridge, Med Res Council, Epidemiol Unit, Cambridge, England
Wareham, NJ:
Univ Cambridge, Med Res Council, Epidemiol Unit, Cambridge, England
:
Hosp Univ Germans Trias I Pujol, Dept Infect Dis, Catalonia, Spain
Hosp Univ Germans Trias I Pujol, IrsiCaixa Aids Res Inst, Catalonia, Spain
Case Western Reserve Univ, Ctr Global Hlth & Dis, Sch Med, Dept Pathol, Cleveland, OH USA
Xie, JQ:
Univ Oxford, Ctr Stat Med, NDORMS, Oxford, England
Univ Oxford, NIHR Biomed Res Ctr Oxford, NDORMS, Oxford, England
Prieto-Alhambra, D:
Univ Oxford, Ctr Stat Med, NDORMS, Oxford, England
Univ Oxford, NIHR Biomed Res Ctr Oxford, NDORMS, Oxford, England
Erasmus Med Ctr Univ, Dept Med Informat, Rotterdam, Netherlands
Green Submitted, Green Accepted, gold
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