Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2
Por:
Ortega-Alarcon, D, Claveria-Gimeno, R, Vega, S, Kalani, L, Jorge-Torres, OC, Esteller, M, Ausio, J, Abian, O and Velazquez-Campoy, A
Publicada:
24 abr 2024
Ahead of Print:
1 feb 2024
Resumen:
MeCP2 is a general regulator of transcription involved in the repression/activation of genes depending on the local epigenetic context. It acts as a chromatin regulator and binds with exquisite specificity to gene promoters. The set of epigenetic marks recognized by MeCP2 has been already established (mainly, cytosine modifications in CpG and CpA), as well as many of the constituents of its interactome. We unveil a new set of interactions for MeCP2 with the four canonical nucleosomal histones. MeCP2 interacts with high affinity with H2A, H2B, H3 and H4. In addition, Rett syndrome associated mutations in MeCP2 and histone epigenetic marks modulate these interactions. Given the abundance and the structural/functional relevance of histones and their involvement in epigenetic regulation, this new set of interactions and its modulating elements provide a new addition to the 'alphabet' for this epigenetic reader.
Graphical Abstract
Filiaciones:
Ortega-Alarcon, D:
Univ Zaragoza, Inst Biocomputat & Phys Complex Syst BIFI, Joint Unit GBsC CSIC BIFI, Zaragoza 50018, Spain
Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza 50009, Spain
Claveria-Gimeno, R:
Certest Biotec SL, Zaragoza 50840, Spain
Vega, S:
Univ Zaragoza, Inst Biocomputat & Phys Complex Syst BIFI, Joint Unit GBsC CSIC BIFI, Zaragoza 50018, Spain
Kalani, L:
Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 2Y2, Canada
:
Josep Carreras Leukaemia Res Inst IJC, Barcelona 08916, Spain
:
Josep Carreras Leukaemia Res Inst IJC, Barcelona 08916, Spain
Ctr Invest Biomed Red Canc CIBERONC, Madrid 28029, Spain
Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona 08010, Spain
Univ Barcelona UB, Sch Med & Hlth Sci, Physiol Sci Dept, Barcelona 08907, Spain
Ausio, J:
Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 2Y2, Canada
Abian, O:
Univ Zaragoza, Inst Biocomputat & Phys Complex Syst BIFI, Joint Unit GBsC CSIC BIFI, Zaragoza 50018, Spain
Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza 50009, Spain
Ctr Invest Biomed Red Area Temat Enfermedades Hepa, Madrid 28029, Spain
Univ Zaragoza, Dept Bioquim & Biol Mol & Celular, Zaragoza 50009, Spain
Velazquez-Campoy, A:
Univ Zaragoza, Inst Biocomputat & Phys Complex Syst BIFI, Joint Unit GBsC CSIC BIFI, Zaragoza 50018, Spain
Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza 50009, Spain
Ctr Invest Biomed Red Area Temat Enfermedades Hepa, Madrid 28029, Spain
Univ Zaragoza, Dept Bioquim & Biol Mol & Celular, Zaragoza 50009, Spain
Green Published, gold
|