Impact of the 2008 economic crisis on the burden of hepatitis B and C diseases in Southern European countries
Por:
Palladino, C, Ramis, R, Ezeonwumelu, IJ, Biondi, A, Carreras, G, Fischer, F, Gallus, S, Golinelli, D, Gorini, G, Hassan, S, Kabir, Z, Koyanagi, A, Lazarus, JV, Mentis, AFA, Meretoja, TJ, Mokdad, AH, Monasta, L, Mulita, F, Postma, MJ, Tabarés-Seisdedos, R, Thiyagarajan, A, Taveira, N and Briz, V
Publicada:
20 jun 2024
Resumen:
Background The economic crisis that began in 2008 has severely affected Southern (Greece, Italy, Portugal, Spain) Western European (SWE) countries of Western Europe (WE) and may have affected ongoing efforts to eliminate viral hepatitis. This study was conducted to investigate the impact of the economic crisis on the burden of HBV and HCV disease. Methods Global Burden of Diseases 2019 data were used to analyse the rates of epidemiological metrics of HBV and HCV acute and chronic infections in SWE and WE. Time series modelling was performed to quantify the impact of healthcare expenditure on the time trend of HBV and HCV disease burden in 2000-2019. Results Declining trends in incidence and prevalence rates of acute HBV (aHBV) and chronic HBV were observed in SWE and WE, with the pace of decline being slower in the post-austerity period (2010-2019) and mortality due to HBV stabilised in SWE. Acute HCV (aHCV) metrics and chronic HCV incidence and mortality showed a stable trend in SWE and WE, whereas the prevalence of chronic HCV showed an oscillating trend, decreasing in WE in 2010-2019 (p < 0.001). Liver cancer due to both hepatitis infections showed a stagnant burden over time. An inverse association was observed between health expenditure and metrics of both acute and chronic HBV and HCV. Conclusions Epidemiological metrics for HBV and HCV showed a slower pace of decline in the post-austerity period with better improvement for HBV, a stabilisation of mortality and a stagnant burden for liver cancer due to both hepatitis infections. The economic crisis of 2008 had a negative impact on the burden of hepatitis B and C. Elimination of HBV and HCV by 2030 will be a major challenge in the SWE countries.
Filiaciones:
Palladino, C:
Univ Lisbon, Res Inst Med, Fac Pharm, Ave Prof Gama Pinto, P-1649003 Lisbon, Lisboa, Portugal
Ramis, R:
Inst Hlth Carlos III, Natl Ctr Epidemiol, Madrid, Spain
:
Autonomous Univ Barcelona, Inst Hlth Sci Res Germans Trias I Pujol, Badalona, Spain
irsiCaixa AIDS Res Inst, Badalona, Spain
Biondi, A:
Univ Catania, Dept Gen Surg & Med Surg Specialties, Catania, Italy
Carreras, G:
Inst Canc Res Prevent & Clin Network, Florence, Italy
Fischer, F:
Charite Med Univ Berlin, Inst Publ Hlth, Berlin, Germany
Gallus, S:
Mario Negri Inst Pharmacol Res, Dept Environm Hlth Sci, Milan, Mario, Italy
Golinelli, D:
Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy
Gorini, G:
Inst Canc Res Prevent & Clin Network, Oncol Network Prevent & Res Inst, Florence, Italy
Hassan, S:
Univ Bergen, Ctr Int Hlth CIH, Bergen, Norway
Univ Bergen, Bergen Ctr Eth & Prior Setting Hlth BCEPS, Bergen, Norway
Kabir, Z:
Univ Coll Cork, Sch Publ Hlth, Cork, Ireland
Koyanagi, A:
San Juan de Dios Sanitary Pk, Barcelona, Spain
Lazarus, JV:
Barcelona Inst Global Hlth, Barcelona, Spain
Mentis, AFA:
BGI Shenzhen, Shenzhen, Guangdong, Peoples R China
Meretoja, TJ:
Helsinki Univ Hosp, Breast Surg Unit, Helsinki, Finland
Univ Helsinki, Helsinki, Finland
Mokdad, AH:
Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA USA
Univ Washington, Sch Med, Dept Hlth Metr Sci, Seattle, WA USA
Monasta, L:
Burlo Garofolo Inst Maternal & Child Hlth, Clin Epidemiol & Publ Hlth Res Unit, Trieste, Italy
Mulita, F:
Gen Univ Hosp Patras, Dept Surg, Patras, Greece
Univ Thessaly, Fac Med, Larisa, Greece
Postma, MJ:
Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands
Univ Padjadjaran, Ctr Excellence Higher Educ Pharmaceut Care Innova, Bandung, Indonesia
Tabarés-Seisdedos, R:
Univ Valencia, Dept Med, Valencia, Spain
Carlos III Hlth Inst, Biomed Res Networking Ctr Mental Hlth Network Cib, Madrid, Spain
Thiyagarajan, A:
Leibniz Inst Prevent Res & Epidemiol, Clin Epidemiol, Bremen, Germany
Taveira, N:
Univ Inst Egas Moniz, Monte De Caparica, Portugal
Univ Lisbon, Res Inst Med, Lisbon, Portugal
Briz, V:
Inst Hlth Carlos III, Natl Ctr Microbiol, Lab Viral Hepatitis, Carretera Majadahonda Pozuelo Km 2-2, Majadahonda 28220, Madrid, Spain
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