Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain
Por:
Karachaliou, M, Moncunill, G, Espinosa, A, Castano-Vinyals, G, Jimenez, A, Vidal, M, Santano, R, Barrios, D, Puyol, L, Carreras, A, Mayer, L, Rubio, R, Cortes, B, Pleguezuelos, V, O'Callaghan-Gordo, C, Fossati, S, Rivas, I, Casabonne, D, Vrijheid, M, Izquierdo, L, Aguilar, R, Basagana, X, Garcia-Aymerich, J, de Cid, R, Dobano, C and Kogevinas, M
Publicada:
3 nov 2021
Ahead of Print:
3 nov 2021
Resumen:
Sparse data exist on the complex natural immunity to SARS-CoV-2 at the population level. We applied a well-validated multiplex serology test in 5000 participants of a general population study in Catalonia in blood samples collected from end June to mid November 2020. Based on responses to fifteen isotype-antigen combinations, we detected a seroprevalence of 18.1% in adults (n = 4740), and modeled extrapolation to the general population of Catalonia indicated a 15.3% seroprevalence. Antibodies persisted up to 9 months after infection. Immune profiling of infected individuals revealed that with increasing severity of infection (asymptomatic, 1-3 symptoms, >= 4 symptoms, admitted to hospital/ICU), seroresponses were more robust and rich with a shift towards IgG over IgA and anti-spike over anti-nucleocapsid responses. Among seropositive participants, lower antibody levels were observed for those >= 60 years vs < 60 years old and smokers vs non-smokers. Overweight/obese participants vs normal weight had higher antibody levels. Adolescents (13-15 years old) (n = 260) showed a seroprevalence of 11.5%, were less likely to be tested seropositive compared to their parents and had dominant anti-spike rather than anti-nucleocapsid IgG responses. Our study provides an unbiased estimate of SARS-CoV-2 seroprevalence in Catalonia and new evidence on the durability and heterogeneity of post-infection immunity.
Filiaciones:
Karachaliou, M:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Moncunill, G:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Ctr Invest Saude Manhica CISM, Maputo, Mozambique
Espinosa, A:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Castano-Vinyals, G:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Jimenez, A:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid 08036, Spain
Vidal, M:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Santano, R:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Barrios, D:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Puyol, L:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
:
Inst Hlth Sci Res Germans Trias & Pujol IGTP, Genomes Life GCAT Lab, Badalona, Spain
Mayer, L:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Rubio, R:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
:
Inst Hlth Sci Res Germans Trias & Pujol IGTP, Genomes Life GCAT Lab, Badalona, Spain
Pleguezuelos, V:
Banc Sang & Teixits BST, Barcelona, Spain
O'Callaghan-Gordo, C:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid 08036, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Univ Oberta Catalunya, Fac Hlth Sci, Barcelona, Spain
Fossati, S:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Rivas, I:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Univ Oberta Catalunya, Fac Hlth Sci, Barcelona, Spain
Casabonne, D:
Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid 08036, Spain
Catalan Inst Oncol, IDIBELL, Unit Mol & Genet Epidemiol Infect & Canc UNIC Mol, Canc Epidemiol Res Programme, Lhospitalet De Llobregat, Spain
Vrijheid, M:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid 08036, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Izquierdo, L:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Aguilar, R:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Basagana, X:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Garcia-Aymerich, J:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid 08036, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
:
Inst Hlth Sci Res Germans Trias & Pujol IGTP, Genomes Life GCAT Lab, Badalona, Spain
Dobano, C:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Ctr Invest Saude Manhica CISM, Maputo, Mozambique
Kogevinas, M:
Barcelona Inst Global Hlth ISGlobal, Barcelona 08036, Spain
Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid 08036, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Hosp del Mar Med Res Inst IMIM, Barcelona 08003, Spain
Green Published, gold
|