Changes in CD4+ T cells subsets in patients with alcohol-related cirrhosis
Por:
Zuluaga, P, Zurera-Egea, C, Fuster, D, Hernandez-Rubio, A, Teniente-Serra, A, Martinez-Cáceres, E and Muga, R
Publicada:
5 ene 2025
Ahead of Print:
5 ene 2025
Resumen:
Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time in CD4(+)subsets in AC-patients. We included patients with alcohol use disorder admitted at least twice for treatment. Patients without evidence of liver disease were the control group (CG). We analyzed na & iuml;ve, memory, TEMRA, Th1, Th2, Th17, early activated, and late activated subsets. During the follow-up, TEMRA T cells were increased (1.2 +/- 1.1% vs. 2.1 +/- 1.1%, p = 0.03) in AC-patients (n = 5) and Th17 cells were decreased (14.1 +/- 4.3% vs. 12.3 +/- 6.4%, p = 0.03) in the CG (n = 22). Late activated cells were associated with a decrease in memory cells in both the groups. This association was stronger in AC-patients (r = - 0.90, p = 0.04). The proportion of memory cells was correlated with an increased of Th1/Th2/Th17 cells in the CG (r = 0.70, r = 0.68, r = 0.63; p < 0.01, respectively), whereas in AC-patients was correlated with a decrease in Th17 cells (r = - 0.90, p = 0.03). AC-patients showed an increase in the proportion of TEMRA T cells, loss of heterogeneity and decreased CD4(+) differentiation.
Filiaciones:
Zuluaga, P:
Univ Autonoma Barcelona, Bellaterra, Spain
Hosp Universitari Germans Trias i Pujol, Dept Internal Med, Ctra Canyet, Badalona, Spain
Zurera-Egea, C:
Univ Autonoma Barcelona, Dept Cell Biol Physiol & Immunol, Bellaterra, Spain
:
Univ Autonoma Barcelona, Bellaterra, Spain
Hosp Universitari Germans Trias i Pujol, Dept Internal Med, Ctra Canyet, Badalona, Spain
Hernandez-Rubio, A:
Hosp Universitari Germans Trias i Pujol, Dept Internal Med, Ctra Canyet, Badalona, Spain
:
Hosp Unive Germans Trias I Pujol, Dept Immunol, Badalona, Spain
:
Hosp Unive Germans Trias I Pujol, Dept Immunol, Badalona, Spain
:
Univ Autonoma Barcelona, Bellaterra, Spain
Hosp Universitari Germans Trias i Pujol, Dept Internal Med, Ctra Canyet, Badalona, Spain
Green Submitted, hybrid
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