Profile of Cytokines Associated with SARS-CoV2 Seropositivity in Multiple Sclerosis Patients and Its Persistence over Six Months
Por:
Sancho-Saldaña, A, Gil-Sánchez, A, Quirant-Sánchez, B, Boigues, M, Canudes, M, Peralta, S, Solana, MJ, González-Mingot, C, Quibus, L, Martínez-Cáceres, E, Torres, P, Hervás, JV, Moreno-Magallon, J and Brieva, L
Publicada:
26 may 2025
Resumen:
Background: Patients with multiple sclerosis (pwMS) receiving disease-modifying therapies (DMTs) may exhibit altered immune responses to infections such as SARS-CoV-2. This study aimed to characterize the cytokine profiles associated with prior SARS-CoV-2 infection and to identify immune markers related to the persistence of the humoral response in pwMS. Methods: A total of 90 pwMS were recruited before the introduction of COVID-19 vaccination in Spain; 46 were seropositive-defined by the presence of IgG, IgM, or IgA antibodies against SARS-CoV-2-and 44 were seronegative. We compared baseline cytokine levels between groups and followed seropositive individuals for six months to assess IgG antibody persistence. Results: Seropositive patients showed significantly lower baseline levels of IL-10, IL-23, and IFN-alpha compared to seronegative individuals. Notably, elevated IL-18 at baseline was associated with persistent IgG seropositivity at six months. Conclusions: These findings suggest a distinct cytokine profile in SARS-CoV-2-exposed pwMS and highlight IL-18 as a potential marker of sustained humoral response. This study provides insight into host-virus immune dynamics in MS patients and may help guide future strategies for infection monitoring and immune evaluation in this population.
Filiaciones:
Sancho-Saldaña, A:
Hosp Arnau Vilanova, Serv Neurol, Lleida 25198, Spain
Inst Recerca Biomed Lleida IRBLleida, Serv Neuroinmunol, Lleida 25198, Spain
Gil-Sánchez, A:
Inst Recerca Biomed Lleida IRBLleida, Serv Neuroinmunol, Lleida 25198, Spain
:
Hosp Univ Germans Trias i Pujol, Germans Trias i Pujol Univ Hosp & Res Inst, Immunol Div, Badalona 08916, Spain
Autonomous Univ Barcelona, Dept Cell Biol Physiol Immunol, Cerdanyola Del Valles 08193, Spain
Boigues, M:
Hosp Univ Germans Trias i Pujol, Germans Trias i Pujol Univ Hosp & Res Inst, Immunol Div, Badalona 08916, Spain
Canudes, M:
Inst Recerca Biomed Lleida IRBLleida, Serv Neuroinmunol, Lleida 25198, Spain
Peralta, S:
Hosp Arnau Vilanova, Serv Neurol, Lleida 25198, Spain
Inst Recerca Biomed Lleida IRBLleida, Serv Neuroinmunol, Lleida 25198, Spain
Solana, MJ:
Hosp Arnau Vilanova, Serv Neurol, Lleida 25198, Spain
Inst Recerca Biomed Lleida IRBLleida, Serv Neuroinmunol, Lleida 25198, Spain
González-Mingot, C:
Hosp Arnau Vilanova, Serv Neurol, Lleida 25198, Spain
Inst Recerca Biomed Lleida IRBLleida, Serv Neuroinmunol, Lleida 25198, Spain
Univ Lleida UdL, Dept Med, Lleida 25198, Spain
Quibus, L:
Inst Recerca Biomed Lleida IRBLleida, Serv Neuroinmunol, Lleida 25198, Spain
:
Hosp Univ Germans Trias i Pujol, Germans Trias i Pujol Univ Hosp & Res Inst, Immunol Div, Badalona 08916, Spain
Autonomous Univ Barcelona, Dept Cell Biol Physiol Immunol, Cerdanyola Del Valles 08193, Spain
Torres, P:
Inst Recerca Biomed Lleida IRBLleida, Serv Neuroinmunol, Lleida 25198, Spain
Univ Lleida UdL, Lleida Biomed Res Inst IRBLleida, Dept Expt Med, Metab Pathophysiol Res Grp, Lleida 25198, Spain
Hervás, JV:
Hosp Sant Joan Despi Moises Broggi, Serv Neurol, Barcelona 08970, Spain
Moreno-Magallon, J:
Inst Recerca Biomed Lleida IRBLleida, Serv Neuroinmunol, Lleida 25198, Spain
Brieva, L:
Hosp Arnau Vilanova, Serv Neurol, Lleida 25198, Spain
Inst Recerca Biomed Lleida IRBLleida, Serv Neuroinmunol, Lleida 25198, Spain
Univ Lleida UdL, Dept Med, Lleida 25198, Spain
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