Liver status and outcomes in patients without previous known liver disease receiving anticoagulant therapy for venous thromboembolism
Por:
Martinez-Urbistondo, D, de la Garza, RG, Villares-Fernandez, P, Font, C, Schellong, S, Lopez-Nunez, JJ, Gil-Diaz, A, Diaz-Pedroche, MD, Hirmerova, J and Monreal, M
Publicada:
1 abr 2022
Ahead of Print:
1 oct 2021
Resumen:
The association between elevated liver enzymes or FIB-4 (fibrosis index 4) and outcome in patients with venous thromboembolism (VTE) has not been evaluated. Data from patients in RIETE (Registro Informatizado Enfermedad TromboEmbolica) were used to assess the association between elevated liver enzymes or FIB-4 levels and the rates of major bleeding or death in apparent liver disease-free patients with acute VTE under anticoagulation therapy. A total of 6206 patients with acute VTE and without liver disease were included. Of them, 92 patients had major bleeding and 168 died under anticoagulation therapy. On multivariable analysis, patients with elevated liver enzymes were at increased mortality risk (HR: 1.58; 95% CI: 1.10-2.28), while those with FIB-4 levels > 2.67 points were at increased risk for major bleeding (HR: 1.69; 95% CI: 1.04-2.74). Evaluation of liver enzymes and FIB-4 index at baseline in liver disease-free patients with VTE may provide additional information on the risk for major bleeding or death during anticoagulation.
Filiaciones:
Martinez-Urbistondo, D:
HM Hosp, HM Sanchinarro, Internal Med Dept, C Ona 10, Madrid 28050, Spain
de la Garza, RG:
HM Hosp, HM Sanchinarro, Internal Med Dept, C Ona 10, Madrid 28050, Spain
Villares-Fernandez, P:
HM Hosp, HM Sanchinarro, Internal Med Dept, C Ona 10, Madrid 28050, Spain
Font, C:
Hosp Clin Barcelona, Dept Med Oncol, Barcelona, Spain
Schellong, S:
Municipal Hosp Dresden Friedrichstad, Dept Med Clin, Dresden, Germany
:
Hosp Badalona Germans Trias & Pujol, Dept Internal Med, Barcelona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Gil-Diaz, A:
Hosp Univ Gran Canaria Dr Negrin, Dept Internal Med, Las Palmas Gran Canaria, Spain
Diaz-Pedroche, MD:
Hosp Univ 12 Octubre, Dept Internal Med, Madrid, Spain
Hirmerova, J:
Univ Hosp Plzen, Dept Internal Med, Plzen, Czech Republic
:
Hosp Badalona Germans Trias & Pujol, Dept Internal Med, Barcelona, Spain
UCAM Univ Catolica San Antonio Murcia, Fac Hlth Sci, Chair Study Thromboembol Dis, Murcia, Spain
Green Published, Bronze
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