Mouthwashes with CPC Reduce the Infectivity of SARS-CoV-2 Variants In Vitro
Por:
Munoz-Basagoiti, J, Perez-Zsolt, D, Leon, R, Blanc, V, Raich-Regue, D, Cano-Sarabia, M, Trinite, B, Pradenas, E, Blanco, J, Gispert, J, Clotet, B and Izquierdo-Useros, N
Publicada:
1 oct 2021
Ahead of Print:
1 jul 2021
Resumen:
Oral mouthwashes decrease the infectivity of several respiratory viruses including SARS-CoV-2. However, the precise agents with antiviral activity in these oral rinses and their exact mechanism of action remain unknown. Here we show that cetylpyridinium chloride (CPC), a quaternary ammonium compound in many oral mouthwashes, reduces SARS-CoV-2 infectivity by inhibiting the viral fusion step with target cells after disrupting the integrity of the viral envelope. We also found that CPC-containing mouth rinses decreased more than a thousand times the infectivity of SARS-CoV-2 in vitro, while the corresponding vehicles had no effect. This activity was effective for different SARS-CoV-2 variants, including the B.1.1.7 or Alpha variant originally identified in United Kingdom, and in the presence of sterilized saliva. CPC-containing mouth rinses could therefore represent a cost-effective measure to reduce SARS-CoV-2 infectivity in saliva, aiding to reduce viral transmission from infected individuals regardless of the variants they are infected with.
Filiaciones:
Munoz-Basagoiti, J:
irsiCaixa AIDS Res Inst, Badalona, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Leon, R:
Dentaid Res Ctr, Cerdanyola Del Valles, Spain
Blanc, V:
Dentaid Res Ctr, Cerdanyola Del Valles, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Cano-Sarabia, M:
CSIC, Catalan Inst Nanosci & Nanotechnol, Bellaterra, Barcelona, Spain
Barcelona Inst Sci & Technol, Bellaterra, Barcelona, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Germans Trias & Pujol Res Inst, Can Ruti Campus, Badalona, Spain
Univ Vic, Cent Univ Catalonia, Vic, Spain
Gispert, J:
Dentaid Res Ctr, Cerdanyola Del Valles, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Germans Trias & Pujol Res Inst, Can Ruti Campus, Badalona, Spain
Univ Vic, Cent Univ Catalonia, Vic, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Germans Trias & Pujol Res Inst, Can Ruti Campus, Badalona, Spain
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