Autoantibodies neutralizing type I IFNs are present in similar to 4% of uninfected individuals over 70 years old and account for similar to 20% of COVID-19 deaths
Por:
Bastard, P, Gervais, A, Le Voyer, T, Rosain, J, Philippot, Q, Manry, J, Michailidis, E, Hoffmann, HH, Eto, S, Garcia-Prat, M, Bizien, L, Parra-Martinez, A, Yang, R, Haljasmagi, L, Migaud, M, Sarekannu, K, Maslovskaja, J, de Prost, N, Tandjaoui-Lambiotte, Y, Luyt, CE, Amador-Borrero, B, Gaudet, A, Poissy, J, Morel, P, Richard, P, Cognasse, F, Troya, J, Trouillet-Assant, S, Belot, A, Saker, K, Garcon, P, Riviere, JG, Lagier, JC, Gentile, S, Rosen, LB, Shaw, E, Morio, T, Tanaka, J, Dalmau, D, Tharaux, PL, Sene, D, Stepanian, A, Megarbane, B, Triantafyllia, V, Fekkar, A, Heath, JR, Franco, JL, Anaya, JM, Sole-Violan, J, Imberti, L, Biondi, A, Bonfanti, P, Castagnoli, R, Delmonte, OM, Zhang, Y, Snow, AL, Holland, SM, Biggs, CM, Moncada-Velez, M, Arias, AA, Lorenzo, L, Boucherit, S, Coulibaly, B, Anglicheau, D, Planas, AM, Haerynck, F, Duvlis, S, Nussbaum, RL, Ozcelik, T, Keles, S, Bousfiha, AA, El Bakkouri, J, Ramirez-Santana, C, Paul, S, Pan-Hammarstrom, Q, Hammarstrom, L, Dupont, A, Kurolap, A, Metz, CN, Aiuti, A, Casari, G, Lampasona, V, Ciceri, F, Barreiros, LA, Dominguez-Garrido, E, Vidigal, M, Zatz, M, van de Beek, D, Sahanic, S, Tancevski, I, Stepanovskyy, Y, Boyarchuk, O, Nukui, Y, Tsumura, M, Vidaur, L, Tangye, SG, Burrel, S, Duffy, D, Quintana-Murci, L, Klocperk, A, Kann, NY, Shcherbina, A, Lau, YL, Leung, D, Coulongeat, M, Marlet, J, Koning, R, Reyes, LF, Chauvineau-Grenier, A, Venet, F, Monneret, G, Nussenzweig, MC, Arrestier, R, Boudhabhay, I, Baris-Feldman, H, Hagin, D, Wauters, J, Meyts, I, Dyer, AH, Kennelly, SP, Bourke, NM, Halwani, R, Sharif-Askari, NS, Dorgham, K, Sallette, J, Sedkaoui, SM, AlKhater, S, Rigo-Bonnin, R, Morandeira, F, Roussel, L, Vinh, DC, Ostrowski, SR, Condino-Neto, A, Prando, C, Bondarenko, A, Spaan, AN, Gilardin, L, Fellay, J, Lyonnet, S, Bilguvar, K, Lifton, RP, Mane, S, Anderson, MS, Boisson, B, Beziat, V, Zhang, SY, Andreakos, E, Hermine, O, Pujol, A, Peterson, P, Mogensen, TH, Rowen, L, Mond, J, Debette, S, de Lamballerie, X, Duval, X, Mentre, F, Zins, M, Soler-Palacin, P, Colobran, R, Gorochov, G, Solanich, X, Susen, S, Martinez-Picado, J, Raoult, D, Vasse, M, Gregersen, PK, Piemonti, L, Rodriguez-Gallego, C, Notarangelo, LD, Su, HC, Kisand, K, Okada, S, Puel, A, Jouanguy, E, Rice, CM, Tiberghien, P, Zhang, Q, Cobat, A, Abel, L and Casanova, JL
Publicada:
1 ago 2021
Resumen:
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-alpha and/or IFN-omega are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-alpha and/or IFN-omega (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-beta. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-alpha and/or IFN-omega are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-beta do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases.
Filiaciones:
Bastard, P:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Gervais, A:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Le Voyer, T:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Rosain, J:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Philippot, Q:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Manry, J:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Michailidis, E:
Rockefeller Univ, Lab Virol & Infect Dis, 1230 York Ave, New York, NY 10021 USA
Hoffmann, HH:
Rockefeller Univ, Lab Virol & Infect Dis, 1230 York Ave, New York, NY 10021 USA
Eto, S:
Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pediat, Hiroshima, Japan
Garcia-Prat, M:
Univ Autonoma Barcelona UAB, Vall dHebron Res Inst, Hosp Univ Vall dHebron, Pediat Infect Dis & Immunodeficiencies Unit, Vall dHebron Barcelona Hosp Campus, Barcelona, Catalonia, Spain
Bizien, L:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Parra-Martinez, A:
Univ Autonoma Barcelona UAB, Vall dHebron Res Inst, Hosp Univ Vall dHebron, Pediat Infect Dis & Immunodeficiencies Unit, Vall dHebron Barcelona Hosp Campus, Barcelona, Catalonia, Spain
Yang, R:
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Haljasmagi, L:
Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia
Migaud, M:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Sarekannu, K:
Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia
Maslovskaja, J:
Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia
de Prost, N:
Hop Univ Henri Mondor, Assistance Publ Hop Paris AP HP, Serv Med Intens Reanimat, Paris, France
Univ Paris Est Creteil, Fac Sante Creteil, Grp Rech Clin CARMAS, 51 Ave Marechal de Lattre de Tassigny, F-94010 Creteil, France
Tandjaoui-Lambiotte, Y:
Avicenne Hosp, AP HP, INSERM U1272, Hypoxia & Lung, Bobigny, France
Luyt, CE:
Sorbonne Univ, Hop Pitie Salpetriere, AP HP, Med Intens Reanimat, Paris, France
INSERM UMRS 1166 iCAN, Inst Cardiometab & Nutr, Paris, France
Amador-Borrero, B:
Paris Univ, Lariboisiere Hosp, AP HP, Internal Med Dept, Paris, France
Gaudet, A:
Univ Lille, U1019 UMR9017, Ctr Infect & Immun Lille, Lille, France
CNRS, UMR9017, Lille, France
INSERM U1019, Lille, France
Inst Pasteur, Lille, France
CHU Lille, Pole Reanimat, Hop Roger Salengro Lille, Lille, France
Poissy, J:
Univ Lille, U1019 UMR9017, Ctr Infect & Immun Lille, Lille, France
CNRS, UMR9017, Lille, France
INSERM U1019, Lille, France
Inst Pasteur, Lille, France
CHU Lille, Pole Reanimat, Hop Roger Salengro Lille, Lille, France
Morel, P:
Etab Francais Sang, La Plaine St Denis, France
Univ Franche Comte, EFS, INSERM, UMR1098 RIGHT, Besancon, France
Richard, P:
Etab Francais Sang, La Plaine St Denis, France
Cognasse, F:
Univ Jean Monnet St Etienne, Univ Lyon, SAINBIOSE, INSERM U1059, St Etienne, France
Etab Francais Sang, St Etienne, France
Troya, J:
Infanta Leonor Univ Hosp, Dept Internal Med, Madrid, Spain
Trouillet-Assant, S:
Hosp Civils Lyon, Lyon, France
Lyon Univ, Int Ctr Res Infectiol, INSERM U1111, CNRS UMR 5308,ENS,UCBL, Lyon, France
Lyon Sud Hosp, Hosp Civils Lyon, Hosp Civils Lyon BioMerieux, Joint Res Unit, Pierre Benite, France
Belot, A:
Hosp Civils Lyon, Lyon, France
Lyon Univ, Int Ctr Res Infectiol, INSERM U1111, CNRS UMR 5308,ENS,UCBL, Lyon, France
Natl Referee Ctr Rheumat & Autoimmune & Syst Dis, Lyon, France
Hosp Civils Lyon, Immunopathol Federat LIFE, Lyon, France
Saker, K:
Hosp Civils Lyon, Lyon, France
Lyon Univ, Int Ctr Res Infectiol, INSERM U1111, CNRS UMR 5308,ENS,UCBL, Lyon, France
Garcon, P:
Grand Hop Est Francilien, Site Marne La Vallee, Intens Care Unit, Jossigny, France
Riviere, JG:
Univ Autonoma Barcelona UAB, Vall dHebron Res Inst, Hosp Univ Vall dHebron, Pediat Infect Dis & Immunodeficiencies Unit, Vall dHebron Barcelona Hosp Campus, Barcelona, Catalonia, Spain
Lagier, JC:
Inst Hosp Univ Mediterranee Infect, Marseille, France
Aix Marseille Univ, IRD, Assistance Publ Hop Marseille APHM, MEPHI, Marseille, France
Gentile, S:
Hop Univ Marseille, AP HM, Serv Evaluat Med, Marseille, France
Aix Marseille Univ, Sch Med, EA 3279, CEReSS Hlth Serv Res & Qual Life Ctr, La Timone Med Campus, Marseille, France
Rosen, LB:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Shaw, E:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Morio, T:
Tokyo Med & Dent Univ TMDU, Grad Sch Med & Dent Sci, Dept Pediat & Dev Biol, Tokyo, Japan
Tanaka, J:
Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Epidemiol Infect Dis Control & Prevent, Hiroshima, Japan
Dalmau, D:
Hosp Univ Mutua Terrassa, Terrassa, Spain
Fundacio Docencia & Recerca MutuaTerrassa, Terrassa, Spain
Univ Barcelona, Barcelona, Spain
Tharaux, PL:
Univ Paris, Paris Cardiovasc Res Ctr, PARCC, INSERM, Paris, France
Sene, D:
Paris Univ, Lariboisiere Hosp, AP HP, Internal Med Dept, Paris, France
Stepanian, A:
Univ Paris Diderot, Hop Lariboisiere, AP HP, Serv Hematol Biol, Paris, France
Univ Paris Diderot, Inst Univ Hematol Hop St Louis, EA3518, Paris, France
Megarbane, B:
Univ Paris Diderot, Hop Lariboisiere, AP HP, Reanimat Med & Toxicol,INSERM,Unite Mixte Rech Sc, Paris, France
Triantafyllia, V:
Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Lab Immunobiol, Athens 11527, Greece
Fekkar, A:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Grp Hosp Pitie Salpetriere, AP HP, Serv Parasitol Mycol, Paris, France
Heath, JR:
Inst Syst Biol, Seattle, WA USA
Franco, JL:
Univ Antioquia UdeA, Sch Med, Dept Microbiol & Parasitol, Primary Immunodeficiencies Grp, Medellin, Colombia
Anaya, JM:
Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res, Bogota, Colombia
Sole-Violan, J:
Univ Hosp Gran Canaria Dr Negrin, Canarian Hlth Syst, Intens Care Med, Las Palmas Gran Canaria, Canary Islands, Spain
Inst Salud Carlos III, CIBER Enfermedades Resp CIBERES, Madrid, Spain
Imberti, L:
ASST Spedali Civili Brescia, Diagnost Dept, CREA Lab, Brescia, Italy
Biondi, A:
Univ Milano Bicocca, Fdn MBBM, Osped San Gerardo, EuroBloodNet,MetabERN,Pediat Dept, Monza, Italy
Univ Milano Bicocca, Fdn MBBM, Osped San Gerardo,EuroBloodNet,MetabERN, Ctr Tettamanti European Reference Network PaedCan, Monza, Italy
Bonfanti, P:
Univ Milano Bicocca, San Gerardo Hosp, Dept Infect Dis, Monza, Italy
Castagnoli, R:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Univ Pavia, Fdn IRCCS Policlin San Matteo, Dept Pediat, Pavia, Italy
Delmonte, OM:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Zhang, Y:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
NIAID, Clin Genom Program, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Snow, AL:
Uniformed Serv Univ Hlth Sci, Dept Pharmacol & Mol Therapeut, Bethesda, MD 20814 USA
Holland, SM:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Biggs, CM:
Univ British Columbia, British Columbia Childrens Hosp, Dept Pediat, Vancouver, BC, Canada
Moncada-Velez, M:
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Arias, AA:
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Univ Antioquia UdeA, Primary Immunodeficiencies Grp, Medellin, Colombia
Univ Antioquia UdeA, Sch Microbiol, Medellin, Colombia
Lorenzo, L:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Boucherit, S:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Coulibaly, B:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Anglicheau, D:
Necker Univ Hosp, AP HP, Dept Nephrol & Transplantat, Paris, France
Paris Univ, INSERM U1151 CNRS UMR 8253, INEM, Paris, France
Planas, AM:
CSIC, Inst Biomed Res IIBB, Barcelona, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain
Haerynck, F:
Ghent Univ Hosp, Ctr Primary Immunodeficiency Ghent, Jeffrey Modell Diag & Res Ctr, Dept Paediat Immunol & Pulmonol, Ghent, Belgium
Duvlis, S:
Univ Goce Delchev, Fac Med Sci, Stip, North Macedonia
Inst Publ Hlth Republ North Macedonia, Skopje, North Macedonia
Nussbaum, RL:
Univ Calif San Francisco, Canc Genet & Prevent Program, San Francisco, CA 94143 USA
Ozcelik, T:
Bilkent Univ, Dept Mol Biol & Genet, Ankara, Turkey
Keles, S:
Necmettin Erbakan Univ, Meram Fac Med, Konya, Turkey
Bousfiha, AA:
Hassan II Univ, CHU Ibn Rushd, Dept Pediat Infect Dis, Clin Immunol Unit, Casablanca, Morocco
Hassan II Univ, Fac Med & Pharm, Lab Immunol Clin Inflammat & Allergie, LICIA, Casablanca, Morocco
El Bakkouri, J:
Hassan II Univ, CHU Ibn Rushd, Dept Pediat Infect Dis, Clin Immunol Unit, Casablanca, Morocco
Hassan II Univ, Fac Med & Pharm, Lab Immunol Clin Inflammat & Allergie, LICIA, Casablanca, Morocco
Ramirez-Santana, C:
Univ Antioquia UdeA, Sch Med, Dept Microbiol & Parasitol, Primary Immunodeficiencies Grp, Medellin, Colombia
Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res, Bogota, Colombia
Paul, S:
Univ Hosp St Etienne, GIMAP Ctr Int Rech Infectiol CIRI INSERM U1111, CIC1408, Dept Immunol, St Etienne, France
Pan-Hammarstrom, Q:
Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden
Hammarstrom, L:
Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden
Dupont, A:
Univ Lille, INSERM, CHU Lille, Inst Pasteur Lille,U1011 EGID, F-59000 Lille, France
Kurolap, A:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Genet Inst, Tel Aviv, Israel
Metz, CN:
Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY USA
Aiuti, A:
Univ Vita Salute San Raffaele, Milan, Italy
IRCCS Osped San Raffaele, Clin Genom, Milan, Italy
Casari, G:
Univ Vita Salute San Raffaele, Milan, Italy
IRCCS Osped San Raffaele, Clin Genom, Milan, Italy
Lampasona, V:
IRCCS San Raffaele Sci Inst, Diabet Res Inst, Milan, Italy
Ciceri, F:
IRCCS San Raffaele Sci Inst, Hematol & Bone Marrow Transplantat Unit, Milan, Italy
Barreiros, LA:
Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, Brazil
Dominguez-Garrido, E:
Ctr Invest Biomed La Rioja, Fdn Rioja Salud, Logrono, Spain
Vidigal, M:
Univ Sao Paulo, Sao Paulo, Brazil
Zatz, M:
Univ Sao Paulo, Sao Paulo, Brazil
van de Beek, D:
Amsterdam Neurosci, Dept Neurol, Amsterdam, Netherlands
Sahanic, S:
Med Univ Innsbruck, Dept Internal Med 2, Innsbruck, Austria
Tancevski, I:
Med Univ Innsbruck, Dept Internal Med 2, Innsbruck, Austria
Stepanovskyy, Y:
Shupyk Natl Healthcare Univ Ukraine, Kiev, Ukraine
Boyarchuk, O:
I Horbachevsky Ternopil Natl Med Univ, Dept Childrens Dis & Pediat Surg, Ternopol, Ukraine
Nukui, Y:
TMDU, Med Hosp, Dept Infect Control & Prevent, Tokyo, Japan
Tsumura, M:
Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pediat, Hiroshima, Japan
Vidaur, L:
Donostia Univ Hosp, Biodonostia Inst Donostia, Intens Care Med, San Sebastian, Spain
Inst Salud Carlos III, CIBERES, Madrid, Spain
Tangye, SG:
Garvan Inst Med Res, Sydney, NSW, Australia
UNSW Sydney, Fac Med & Hlth, St Vincents Clin Sch, Sydney, NSW, Australia
Burrel, S:
Sorbonne Univ, INSERM U1136, Inst Pierre Louis Epidemiol & Sante Publ iPLESP, Hop Pitie Salpetriere,AP HP,Serv Virol, Paris, France
Duffy, D:
Inst Pasteur, Translat Immunol Lab, Paris, France
Quintana-Murci, L:
Inst Pasteur, Human Evolutionary Genet Unit, CNRS UMR 2000, Paris, France
Coll France, Chair Human Genom & Evolut, Paris, France
Klocperk, A:
Charles Univ Prague, Fac Med 2, Dept Immunol, Prague, Czech Republic
Univ Hosp Motol, Prague, Czech Republic
Kann, NY:
Dmitry Rogachev Natl Med Res Ctr Pediat Hematol O, Moscow, Russia
Shcherbina, A:
Dmitry Rogachev Natl Med Res Ctr Pediat Hematol O, Moscow, Russia
Lau, YL:
Univ Hong Kong, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China
Leung, D:
Univ Hong Kong, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China
Coulongeat, M:
Tours Univ Med Ctr, Div Geriatr Med, Tours, France
Marlet, J:
Univ Tours, MAVIVH, INSERM U1259, Tours, France
CHU Tours, Serv Bacteriol Virol & Hyg Hosp, Tours, France
Koning, R:
Amsterdam Neurosci, Dept Neurol, Amsterdam, Netherlands
Reyes, LF:
Univ La Sabana, Dept Microbiol, Chia, Colombia
Clin Univ La Sabana, Dept Crit Care Med, Chia, Colombia
Chauvineau-Grenier, A:
CHI Robert Ballanger, Serv Biol Med, Aulnay Sous Bois, France
Venet, F:
Hosp Civils Lyon, Lab Immunol, Hop Edouard Herriot, Lyon, France
Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon, UMR5308, CIRI,INSERM U1111,CNRS, Lyon, France
Univ Claude Bernard Lyon 1, Hosp Civils Lyon, Hop Edouard Herriot BioMerieux, EA 7426,Pathophysiol Injury Induced Immunosuppres, Lyon, France
Monneret, G:
Hosp Civils Lyon, Lab Immunol, Hop Edouard Herriot, Lyon, France
Univ Claude Bernard Lyon 1, Hosp Civils Lyon, Hop Edouard Herriot BioMerieux, EA 7426,Pathophysiol Injury Induced Immunosuppres, Lyon, France
Nussenzweig, MC:
Rockefeller Univ, Lab Mol Immunol, 1230 York Ave, New York, NY 10021 USA
Howard Hughes Med Inst, New York, NY 10065 USA
Arrestier, R:
Hop Univ Henri Mondor, Assistance Publ Hop Paris AP HP, Serv Med Intens Reanimat, Paris, France
Univ Paris Est Creteil, Fac Sante Creteil, Grp Rech Clin CARMAS, 51 Ave Marechal de Lattre de Tassigny, F-94010 Creteil, France
Boudhabhay, I:
Necker Univ Hosp, AP HP, Dept Nephrol & Transplantat, Paris, France
Paris Univ, INSERM U1151 CNRS UMR 8253, INEM, Paris, France
Baris-Feldman, H:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Genet Inst, Tel Aviv, Israel
Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
Hagin, D:
Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
Tel Aviv Sourasky Med Ctr, Dept Med, Allergy & Clin Immunol Unit, Tel Aviv, Israel
Wauters, J:
Univ Hosp Leuven, Med Intens Care Unit, Leuven, Belgium
Meyts, I:
Katholieke Univ Leuven, Lab Inborn Errors Immun, Dept Microbiol Immunol & Transplantat, Leuven, Belgium
Univ Hosp Leuven, Jeffrey Modell Diagnost & Res Network Ctr, Dept Pediat, Leuven, Belgium
Dyer, AH:
Tallaght Univ Hosp, Dept Age Related Healthcare, Dublin, Ireland
Trinity Coll Dublin, Sch Med, Dept Med Gerontol, Dublin, Ireland
Kennelly, SP:
Tallaght Univ Hosp, Dept Age Related Healthcare, Dublin, Ireland
Trinity Coll Dublin, Sch Med, Dept Med Gerontol, Dublin, Ireland
Bourke, NM:
Trinity Coll Dublin, Sch Med, Dept Med Gerontol, Dublin, Ireland
Halwani, R:
Univ Sharjah, Coll Med, Sharjah Inst Med Res, Sharjah, U Arab Emirates
Sharif-Askari, NS:
Univ Sharjah, Coll Med, Sharjah Inst Med Res, Sharjah, U Arab Emirates
Dorgham, K:
Sorbonne Univ, Ctr Immunol & Malad Infect, CIMI Paris, INSERM, Paris, France
Sallette, J:
Cerba HealthCare, Issy Les Moulineaux, France
Sedkaoui, SM:
Cerba HealthCare, Issy Les Moulineaux, France
AlKhater, S:
King Fahad Hosp Univ, Dept Pediat, Al Khobar, Saudi Arabia
Imam Abdulrahman Bin Faisal Univ, Coll Med, Dammam, Saudi Arabia
Rigo-Bonnin, R:
Hosp Univ Bellvitge, Dept Clin Lab, IDIBELL, Barcelona, Spain
Morandeira, F:
Hosp Univ Bellvitge, Dept Immunol, IDIBELL, Barcelona, Spain
Roussel, L:
McGill Univ Hlth Ctr, Dept Med, Div Infect Dis, Montreal, PQ, Canada
McGill Univ Hlth Ctr, Res Inst, Infect Dis Susceptibil Program, Montreal, PQ, Canada
Vinh, DC:
McGill Univ Hlth Ctr, Dept Med, Div Infect Dis, Montreal, PQ, Canada
McGill Univ Hlth Ctr, Res Inst, Infect Dis Susceptibil Program, Montreal, PQ, Canada
Ostrowski, SR:
Copenhagen Univ Hosp, Rishosp, Dept Clin Immunol, Copenhagen, Denmark
Condino-Neto, A:
Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, Brazil
Prando, C:
Inst Pesquisa Pele Pequeno Principe, Fac Pequeno Principe, Curitiba, Parana, Brazil
Bondarenko, A:
Shupyk Natl Healthcare Univ Ukraine, Kiev, Ukraine
Spaan, AN:
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands
Gilardin, L:
Hop Univ Jean Verdier, AP HP, Serv Med Interne, Bondy, France
Ctr Rech Cordeliers, INSERM U1138, Paris, France
Fellay, J:
Ecole Polytech Fed Lausanne, Sch Life Sci, Lausanne, Switzerland
Lausanne Univ Hosp, Precis Med Unit, Lausanne, Switzerland
Univ Lausanne, Lausanne, Switzerland
Swiss Inst Bioinformat, Lausanne, Switzerland
Lyonnet, S:
Univ Paris, Imagine Inst, INSERM UMR 1163, Paris, France
Bilguvar, K:
Yale Sch Med, Yale Ctr Genome Anal, New Haven, CT USA
Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA
Yale Univ, Dept Neurosurg, Sch Med, New Haven, CT USA
Acibadem Univ, Dept Med Genet, Sch Med, Istanbul, Turkey
Lifton, RP:
Yale Sch Med, Yale Ctr Genome Anal, New Haven, CT USA
Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA
Rockefeller Univ, Lab Human Genet & Genom, 1230 York Ave, New York, NY 10021 USA
Mane, S:
Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA
Anderson, MS:
Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94143 USA
Boisson, B:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Beziat, V:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Zhang, SY:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Andreakos, E:
Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Lab Immunobiol, Athens 11527, Greece
Hermine, O:
Univ Paris, Imagine Inst, Paris, France
Hop Necker Enfants Malad, AP HP, Dept Hematol, Paris, France
Pujol, A:
Hosp Duran & Reynals, IDIBELL, Neurometab Dis Lab, CIBERER U759, Barcelona, Spain
Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain
Peterson, P:
Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia
Mogensen, TH:
Aarhus Univ Hosp, Dept Infect Dis, Aarhus, Denmark
Aarhus Univ, Dept Biomed, Aarhus, Denmark
Rowen, L:
Inst Syst Biol, Seattle, WA USA
Mond, J:
ADMA Biol Inc, Ramsey, NJ USA
Debette, S:
Univ Bordeaux, Bordeaux Populat Hlth Ctr, UMR1219, INSERM, F-33000 Bordeaux, France
Bordeaux Univ Hosp, Inst Neurodegenerat Dis, Dept Neurol, F-33000 Bordeaux, France
de Lamballerie, X:
UVE Aix Marseille Univ, Unite Virus Emergents, IHU Mediterranee Infect, IRD 190,INSERM 1207, Marseille, France
Duval, X:
INSERM CIC 1425, Paris, France
Univ Paris, INSERM, IAME UMR S 1137, Paris, France
Hop Bichat Claude Bernard, AP HP, Dept Epidemiol Biostat & Rech Clin, Paris, France
Bichat Claude Bernard Hosp, AP HP, Infect & Trop Dis Dept, Paris, France
Mentre, F:
INSERM CIC 1425, Paris, France
Univ Paris, INSERM, IAME UMR S 1137, Paris, France
Hop Bichat Claude Bernard, AP HP, Dept Epidemiol Biostat & Rech Clin, Paris, France
Zins, M:
Univ Paris, Univ Paris Saclay, INSERM UMS11, UVSQ, Villejuif, France
Soler-Palacin, P:
Univ Autonoma Barcelona UAB, Vall dHebron Res Inst, Hosp Univ Vall dHebron, Pediat Infect Dis & Immunodeficiencies Unit, Vall dHebron Barcelona Hosp Campus, Barcelona, Catalonia, Spain
Colobran, R:
Hosp Univ Vall dHebron, Vall dHebron Res Inst, Genet Dept, Immunol Div, Vall dHebron Barcelona Hosp Campus, Barcelona, Catalonia, Spain
Gorochov, G:
Sorbonne Univ, Ctr Immunol & Malad Infect, CIMI Paris, INSERM, Paris, France
Hop La Pitie Salpetriere, AP HP, Dept Immunol, Paris, France
Solanich, X:
Hosp Univ Bellvitge, Dept Internal Med, IDIBELL, Barcelona, Spain
Susen, S:
Univ Lille, INSERM, CHU Lille, Inst Pasteur Lille,U1011 EGID, F-59000 Lille, France
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Inst Hlth Sci Res Germans Trias & Pujol IGTP, Badalona, Spain
Univ Vic Cent Univ Catalonia UVic UCC, Fac Med, Ctr Hlth & Social Care Res CESS, Infect Dis & Immun, Vic, Spain
Catalan ICREA, Barcelona, Spain
Raoult, D:
Inst Hosp Univ Mediterranee Infect, Marseille, France
Aix Marseille Univ, IRD, Assistance Publ Hop Marseille APHM, MEPHI, Marseille, France
Vasse, M:
Hop Foch, Serv Biol Clin, Suresnes, France
Hop Foch, UMR S 1176, Suresnes, France
Gregersen, PK:
Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY USA
Piemonti, L:
IRCCS San Raffaele Sci Inst, Diabet Res Inst, Milan, Italy
Rodriguez-Gallego, C:
Univ Hosp Gran Canaria Dr Negrin, Canarian Hlth Syst, Dept Immunol, Las Palmas Gran Canaria, Spain
Univ Fernando Pessoa Canarias, Dept Clin Sci, Las Palmas Gran Canaria, Spain
Notarangelo, LD:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Su, HC:
NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA
Kisand, K:
Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia
Okada, S:
Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pediat, Hiroshima, Japan
Puel, A:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Jouanguy, E:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Rice, CM:
Rockefeller Univ, Lab Virol & Infect Dis, 1230 York Ave, New York, NY 10021 USA
Tiberghien, P:
Etab Francais Sang, La Plaine St Denis, France
Univ Franche Comte, EFS, INSERM, UMR1098 RIGHT, Besancon, France
Zhang, Q:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Cobat, A:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Abel, L:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Casanova, JL:
Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris, France
Univ Paris, Imagine Inst, Paris, France
Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA
Howard Hughes Med Inst, New York, NY 10065 USA
Green Published, Green Accepted
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