Cyclin-dependent Kinases as Emerging Targets for Developing Novel Antiviral Therapeutics
Por:
Gutierrez-Chamorro, L, Felip, E, Ezeonwumelu, IJ, Margeli, M and Ballana, E
Publicada:
1 sep 2021
Ahead of Print:
1 ago 2021
Resumen:
Besides its prominent role in cell proliferation, cyclin-dependent kinases (CDKs) are key players in viral infections as both DNA and RNA viruses modify CDK function to favor viral replication. Recently, a number of specific pharmacological CDK inhibitors have been developed and approved for cancer treatment. The repurposing of these specific CDK inhibitors for the treatment of viral infections may represent a novel effective therapeutic strategy to combat old and emergent viruses. In this review, we describe the role, mechanisms of action, and potential of CDKs as antiviral drug targets. We also discuss the current clinical state of novel specific CDK inhibitors, focusing on their putative use as antivirals, especially against new emerging viruses.
Filiaciones:
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Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Germans Trias & Pujol IGTP, AIDS Res Inst IrsiCaixa & Hlth Res, Badalona 08916, Spain
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Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Germans Trias & Pujol IGTP, AIDS Res Inst IrsiCaixa & Hlth Res, Badalona 08916, Spain
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, BARGO Badalona Appl Res Grp Oncol & Hlth Res, ICO Badalona,Inst Trias & Pujol IGTP, Badalona 08916, Spain
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Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Germans Trias & Pujol IGTP, AIDS Res Inst IrsiCaixa & Hlth Res, Badalona 08916, Spain
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Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, BARGO Badalona Appl Res Grp Oncol & Hlth Res, ICO Badalona,Inst Trias & Pujol IGTP, Badalona 08916, Spain
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Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Germans Trias & Pujol IGTP, AIDS Res Inst IrsiCaixa & Hlth Res, Badalona 08916, Spain
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