Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic?
Por:
Fernandez-Sojo, J, Azqueta, C, Valdivia, E, Martorell, L, Medina-Boronat, L, Martinez-Llonch, N, Torrents, S, Codinach, M, Canals, C, Elorza, I, Parody, R, Martino, R, Trabazo, M, de Heredia, CD, Ferra, C, Valcarcel, D, Linares, M, Ancochea, A, Garcia-Rey, E, Garcia-Munoz, N, Medina, L, Castillo, N, Carreras, E, Villa, J and Querol, S
Publicada:
1 oct 2021
Ahead of Print:
1 jun 2021
Resumen:
Cryopreservation was recommended to ensure continuity of unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) during COVID-19 pandemic. However, its impact on clinical outcomes and feasibility was not well known. We compared 32 patients who underwent UD HSCT using cryopreserved peripheral blood stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC in the previous period. Median neutrophil engraftment was 17.5 and 17.0 days with cryopreserved and fresh grafts, respectively. Non-significant delays were found in platelet recovery days (25.5 versus 19.0; P = 0.192) and full donor chimerism days (35.0 and 31.5; P = 0.872) using cryopreserved PBSC. The rate of acute graft-versus-host disease at 100 days was 41% (95% CI [21-55%]) in cryopreserved group versus 31% (95% CI [13-46%]) in fresh group (P = 0.380). One-hundred days progression-relapse free survival and overall survival did not differ significantly. During COVID-19 pandemic, six frozen UD donations were not transfused and logistical and clinical issues regarding cryopreservation procedure, packaging, and transporting appeared. In summary, UD HSCT with cryopreserved PBSC was safe during this challenging time. More efforts are needed to ensure that all frozen grafts are transplanted and cryopreservation requirements are harmonized.
Filiaciones:
Fernandez-Sojo, J:
Banc Sang & Teixits, Barcelona, Spain
Azqueta, C:
Banc Sang & Teixits, Barcelona, Spain
Valdivia, E:
Banc Sang & Teixits, Barcelona, Spain
Martorell, L:
Banc Sang & Teixits, Barcelona, Spain
Medina-Boronat, L:
Banc Sang & Teixits, Barcelona, Spain
Martinez-Llonch, N:
Banc Sang & Teixits, Barcelona, Spain
Torrents, S:
Banc Sang & Teixits, Barcelona, Spain
Codinach, M:
Banc Sang & Teixits, Barcelona, Spain
Canals, C:
Banc Sang & Teixits, Barcelona, Spain
Elorza, I:
Hosp St Joan Deu, Pediat Hematol Dept, Barcelona, Spain
Parody, R:
Inst Catala Oncol Hosp, Adult Hematol Dept, Barcelona, Spain
Martino, R:
Hosp Univ Santa Creu & St Pau, Adult Hematol Dept, Barcelona, Spain
Trabazo, M:
Hosp Univ Santa Creu & St Pau, Pediat Hematol Dept, Barcelona, Spain
de Heredia, CD:
Hosp Univ Vall dHebron, Pediat Hematol Dept, Barcelona, Spain
:
Inst Catala Oncologia Badalona, Adult Hematol Dept, Barcelona, Spain
Valcarcel, D:
Hosp Univ Vall dHebron, Adult Hematol Dept, Barcelona, Spain
Linares, M:
Hosp Univ Vall dHebron, Banc Sang & Teixits, Barcelona, Spain
:
Hosp Badalona Germans Trias & Pujol, Banc Sang & Teixits, Badalona, Spain
Garcia-Rey, E:
Hosp St Joan Deu, Banc Sang & Teixits, Barcelona, Spain
Garcia-Munoz, N:
Hosp Univ Bellvitge, Banc Sang & Teixits, Barcelona, Spain
Medina, L:
Hosp Univ Santa Creu & St Pau, Banc Sang & Teixits, Barcelona, Spain
Castillo, N:
Hosp Mutua Terrassa, Banc Sang & Teixits, Barcelona, Spain
:
Josep Carreras Fdn, Spanish Bone Marrow Donor Registry, Barcelona, Spain
Leukemia Res Inst, Barcelona, Spain
Villa, J:
Josep Carreras Fdn, Spanish Bone Marrow Donor Registry, Barcelona, Spain
Leukemia Res Inst, Barcelona, Spain
Querol, S:
Banc Sang & Teixits, Barcelona, Spain
Bronze, Green Published
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