Incidence of Recurrent High-Grade Anal Dysplasia in HIV-1-Infected Men and Women Following Infrared Coagulation Ablation: A Retrospective Cohort Study
Por:
Corral, J, Pares, D, Garcia-Cuyas, F, Revollo, B, Chamorro, A, Lecumberri, C, Tarrats, A, Castella, E, Pinol, M, Clotet, B, Videla, S and Sirera, G
Publicada:
1 feb 2021
Ahead of Print:
14 feb 2021
Resumen:
This single-center, retrospective cohort study sought to estimate the cumulative incidence in HIV-1-infected patients of biopsy-proven high-grade anal intraepithelial neoplasia (HGAIN) recurrence after infrared coagulation (IRC) treatment. The study was based on data from a prospectively compiled database of 665 HIV-1-infected outpatients who attended a hospital Clinical Proctology/HIV Unit between January 2012 and December 2015. Patient records were checked to see which ones had received IRC treatment but later experienced a recurrence of HGAIN. Cytology samples were also checked for the presence of human papilloma virus (HPV). A total of 81 of the 665 patients (12%, 95%CI: 10-15%), of whom 65 were men and 16 women, were diagnosed with HGAIN and again treated with IRC. Of these 81, 20 (25%) experienced recurrent HGAIN, this incidence being true of both men (16/65, 95%CI: 19-57%) and women (4/16, 95%CI: 10-50%). The median time to recurrence was 6 (2-19) months overall, 6 (2-19) months in men, and 4 (2-6) months in women. HPV infection was detected in all patients except two, with HPV-16 being the most common genotype. This rate of incidence of recurrent HGAIN following IRC treatment is consistent with other reports and highlights the importance of continued post-treatment surveillance, particularly in the first year.
Filiaciones:
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Hosp Badalona Germans Trias & Pujol, Dept Gen Surg, Carretera Canyet S-N, Barcelona 08916, Spain
Hosp Badalona Germans Trias & Pujol, Lluita Sida Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
Univ Autonoma Barcelona UAB, Sch Med, Edifici M,Av Can Domenech, Barcelona 08193, Spain
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Hosp Badalona Germans Trias & Pujol, Dept Gen Surg, Carretera Canyet S-N, Barcelona 08916, Spain
Hosp Badalona Germans Trias & Pujol, Lluita Sida Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
Univ Autonoma Barcelona UAB, Sch Med, Edifici M,Av Can Domenech, Barcelona 08193, Spain
Garcia-Cuyas, F:
Hosp Badalona Germans Trias & Pujol, Dept Gen Surg, Carretera Canyet S-N, Barcelona 08916, Spain
Hosp Badalona Germans Trias & Pujol, Lluita Sida Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
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Hosp Badalona Germans Trias & Pujol, Lluita Sida Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
Univ Hosp Germans Trias & Pujol, Dept Med, HIV Clin Unit, Carretera Canyet S-N, Barcelona 08916, Spain
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Hosp Badalona Germans Trias & Pujol, Lluita Sida Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
Univ Hosp Germans Trias & Pujol, Dept Med, HIV Clin Unit, Carretera Canyet S-N, Barcelona 08916, Spain
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Hosp Badalona Germans Trias & Pujol, Lluita Sida Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
Hosp Badalona Germans Trias & Pujol, Dept Obstet & Gynaecol, Carretera Canyet S-N, Barcelona 08916, Spain
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Hosp Badalona Germans Trias & Pujol, Lluita Sida Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
Hosp Badalona Germans Trias & Pujol, Dept Obstet & Gynaecol, Carretera Canyet S-N, Barcelona 08916, Spain
Castella, E:
Hosp Badalona Germans Trias & Pujol, Dept Pathol, Carretera Canyet S-N, Barcelona 08916, Spain
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Hosp Badalona Germans Trias & Pujol, Dept Gen Surg, Carretera Canyet S-N, Barcelona 08916, Spain
Hosp Badalona Germans Trias & Pujol, Lluita Sida Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
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Hosp Badalona Germans Trias & Pujol, Lluita Sida Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
Univ Autonoma Barcelona UAB, Sch Med, Edifici M,Av Can Domenech, Barcelona 08193, Spain
Retrovirol Lab IrsiCaixa Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
Videla, S:
Hosp Badalona Germans Trias & Pujol, Lluita Sida Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
Univ Barcelona, Hosp Llobregat, Dept Clin Pharmacol, Bellvitge Univ Hosp,IDIBELL, Gran Via Les Corts Catalanes 199-203, Barcelona 08907, Spain
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Hosp Badalona Germans Trias & Pujol, Lluita Sida Fdn, Carretera Canyet S-N, Barcelona 08916, Spain
Green Published, gold
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