Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure
Por:
Teis, A, Cediel, G, Amigo, N, Julve, J, Aranyo, J, Andres-Cordon, J, Puig-Jove, C, Castelblanco, E, Gual-Capllonch, F, Ferrer-Sistach, E, Vallejo, N, Junca, G, Lopez-Ayerbe, J, de Antonio, M, Domingo, M, Santiago-Vacas, E, Codina, P, Mauricio, D, Lupon, J, Alonso, N and Bayes-Genis, A
Publicada:
4 feb 2021
Ahead of Print:
4 feb 2021
Resumen:
Evidence regarding any association of HDL-particle (HDL-P) derangements and HDL-cholesterol content with cardiovascular (CV) death in chronic heart failure (HF) is lacking. To investigate the prognostic value of HDL-P size (HDL-Sz) and the number of cholesterol molecules per HDL-P for CV death in HF patients. Outpatient chronic HF patients were enrolled. Baseline HDL-P number, subfractions and HDL-Sz were measured using 1H-NMR spectroscopy. The HDL-C/P ratio was calculated as HDL-cholesterol over HDL-P. Endpoint was CV death, with non-CV death as the competing event. 422 patients were included and followed-up during a median of 4.1 (0-8) years. CV death occurred in 120 (30.5%) patients. Mean HDL-Sz was higher in CV dead as compared with survivors (8.39 nm vs. 8.31 nm, p<0.001). This change in size was due to a reduction in the percentage of small HDL-P (54.6% vs. 60% for CV-death vs. alive; p<0.001). HDL-C/P ratio was higher in the CV-death group (51.0 vs. 48.3, p<0.001). HDL-Sz and HDL-C/P ratio were significantly associated with CV death after multivariable regression analysis (HR 1.22 [95% CI 1.01-1.47], p=0.041 and HR 1.04 [95% CI 1.01-1.07], p=0.008 respectively). HDL-Sz and HDL-C/P ratio are independent predictors of CV death in chronic HF patients.
Filiaciones:
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Germans Trias Univ Hosp, Cardiol Dept, Heart Inst, Carretera Canyet S-N, Barcelona 08916, Spain
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
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Germans Trias Univ Hosp, Cardiol Dept, Heart Inst, Carretera Canyet S-N, Barcelona 08916, Spain
Amigo, N:
Biosfer Teslab SL, Reus, Spain
Rovira & Virgili Univ URV, Inst Invest Sanit Pere Virigili IISPV, Metabol Platform, Tarragona, Spain
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Barcelona, Spain
Julve, J:
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed, IIB St Pau, Barcelona, Spain
Aranyo, J:
Germans Trias Univ Hosp, Cardiol Dept, Heart Inst, Carretera Canyet S-N, Barcelona 08916, Spain
Andres-Cordon, J:
Germans Trias Univ Hosp, Cardiol Dept, Heart Inst, Carretera Canyet S-N, Barcelona 08916, Spain
Puig-Jove, C:
Germans Trias Univ Hosp, Endocrinol & Nutr Dept, Barcelona, Spain
Castelblanco, E:
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed, IIB St Pau, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Endocrinol & Nutr Dept, Barcelona, Spain
Gual-Capllonch, F:
Germans Trias Univ Hosp, Cardiol Dept, Heart Inst, Carretera Canyet S-N, Barcelona 08916, Spain
Ferrer-Sistach, E:
Germans Trias Univ Hosp, Cardiol Dept, Heart Inst, Carretera Canyet S-N, Barcelona 08916, Spain
:
Germans Trias Univ Hosp, Cardiol Dept, Heart Inst, Carretera Canyet S-N, Barcelona 08916, Spain
Junca, G:
Germans Trias Univ Hosp, Cardiol Dept, Heart Inst, Carretera Canyet S-N, Barcelona 08916, Spain
Lopez-Ayerbe, J:
Germans Trias Univ Hosp, Cardiol Dept, Heart Inst, Carretera Canyet S-N, Barcelona 08916, Spain
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Germans Trias Univ Hosp, Heart Failure Unit, Heart Inst, Barcelona, Spain
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Germans Trias Univ Hosp, Heart Failure Unit, Heart Inst, Barcelona, Spain
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Germans Trias Univ Hosp, Heart Failure Unit, Heart Inst, Barcelona, Spain
:
Germans Trias Univ Hosp, Heart Failure Unit, Heart Inst, Barcelona, Spain
Mauricio, D:
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed, IIB St Pau, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Endocrinol & Nutr Dept, Barcelona, Spain
Univ Lleida, Lleida Biomed Res Inst Dr Pifarre Fdn IRBLleid, Lleida, Spain
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Germans Trias Univ Hosp, Heart Failure Unit, Heart Inst, Barcelona, Spain
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Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Inst Salud Carlos III, Ctr Biomed Res Diabet & Associated Metab Dis CIBE, Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Heart Failure Unit, Endocrinol & Nutr Dept, Carretera Canyet S-N, Barcelona 08916, Spain
:
Germans Trias Univ Hosp, Cardiol Dept, Heart Inst, Carretera Canyet S-N, Barcelona 08916, Spain
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Inst Salud Carlos III, Ctr Biomed Res Cardiovasc Dis CIBERCV, Barcelona, Spain
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