Immunological and physiopathological approach of COVID-19 in pregnancy
Por:
Ferrer-Oliveras, R, Mendoza, M, Capote, S, Pratcorona, L, Esteve-Valverde, E, Cabero-Roura, L and Alijotas-Reig, J
Publicada:
1 jul 2021
Ahead of Print:
1 may 2021
Resumen:
Coronavirus disease-2019 (COVID-19) related to Coronavirus-2 (SARS-CoV-2) is a worldwide health concern. Despite the majority of patients will evolve asymptomatic or mild-moderate upper respiratory tract infections, 20% will develop severe disease. Based on current pathogenetic knowledge, a severe COVID-19 form is mainly a hyperinflammatory, immune-mediated disorder, triggered by a viral infection. Due to their particular immunological features, pregnant women are supposed to be particularly susceptible to complicate by intracellular infections as well as immunological disturbances. As an example, immune-thrombosis has been identified as a common immune-mediated and pathogenic phenomenon both in COVID-19, in obstetric diseases and in COVID-19 pregnant women. According to extensive published clinical data, is rationale to expect an interference with the normal development of pregnancy in selected SARS-CoV-2-infected cases, mainly during third trimester. This manuscript provides insights of research to elucidate the potential harmful responses to SARS-CoV-2 and /or other coronavirus infections, as well as bidirectional interactions between COVID-19 and pregnancy to improve their respective management.
Filiaciones:
Ferrer-Oliveras, R:
Hosp Univ Quironsalud Barcelona, Dept Obstet & Gynaecol, Barcelona, Catalonia, Spain
Mendoza, M:
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Dept Obstet, Maternal Fetal Med Unit, Barcelona, Catalonia, Spain
Capote, S:
Hosp Univ Quironsalud Barcelona, Dept Obstet & Gynaecol, Barcelona, Catalonia, Spain
:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Dept Obstet, Barcelona, Catalonia, Spain
Esteve-Valverde, E:
Althaia Network Hlth Manresa, Dept Internal Med, Barcelona, Spain
Univ Cent Catalunya, Barcelona, Catalonia, Spain
Cabero-Roura, L:
Hosp Univ Quironsalud Barcelona, Dept Obstet & Gynaecol, Barcelona, Catalonia, Spain
Univ Autonoma Barcelona, Obster & Gynaecol, Barcelona, Catalonia, Spain
Alijotas-Reig, J:
Vall dHebron Univ Hosp, Dept Internal Med 1, Syst Autoimmune Dis Unit, Barcelona, Spain
Vall dHebron Reseacrh Inst, Syst Autoimmune Res Unit, Barcelona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Bronze, Green Published
|