The time to offer treatments for COVID-19
Por:
Ngo, BT, Marik, P, Kory, P, Shapiro, L, Thomadsen, R, Iglesias, J, Ditmore, S, Rendell, M, Varon, J, Dube, M, Nanda, N, In, G, Arkfeld, D, Chaudhary, P, Campese, VM, Hanna, DL, Sawcer, DE, Ehresmann, G, Peng, DV, Smogorewski, M, Armstrong, A, Dasgupta, R, Sattler, F, Brennan-Rieder, D, Mussini, C, Mitja, O, Soriano, V, Peschanski, N, Hayem, G, Confalonieri, M, Piccirillo, MC, Lobo-Ferreira, A, Rivero, IB, Turkia, M, Vingevoll, EH, Griffin, D and Hung, IF
Publicada:
4 may 2021
Ahead of Print:
1 abr 2021
Resumen:
Background: COVID-19 has several overlapping phases. Treatments to date have focused on the late stage of disease in hospital. Yet, the pandemic is by propagated by the viral phase in out-patients. The current public health strategy relies solely on vaccines to prevent disease.Methods: We searched the major national registries, pubmed.org, and the preprint servers for all ongoing, completed and published trial results.Results: As of 2/15/2021, we found 111 publications reporting findings on 14 classes of agents, and 9 vaccines. There were 62 randomized controlled studies, the rest retrospective observational analyses. Only 21 publications dealt with outpatient care. Remdesivir and high titer convalescent plasma have emergency use authorization for hospitalized patients in the U.S.A. There is also support for glucocorticoid treatment of the COVID-19 respiratory distress syndrome. Monoclonal antibodies are authorized for outpatients, but supply is inadequate to treat all at time of diagnosis. Favipiravir, ivermectin, and interferons are approved in certain countries.Expert Opinion: Vaccines and antibodies are highly antigen specific, and new SARS-Cov-2 variants are appearing. We call on public health authorities to authorize treatments with known low-risk and possible benefit for outpatients in parallel with universal vaccination.
Filiaciones:
Ngo, BT:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Rose Salter Med Res Fdn, Newport Coast, CA 92657 USA
Marik, P:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Kory, P:
Aurora St Lukes Med Ctr, Pulm & Crit Care Med, Milwaukee, WI USA
Shapiro, L:
Rocky Mt Reg Vet Affairs Med Ctr, Dept Internal Med, Aurora, CO USA
Univ Colorado, Anschutz Med Campus, Aurora, CO USA
Thomadsen, R:
Washington Univ, Dept Mkt, St Louis, MO 63110 USA
Iglesias, J:
Jersey Shore Univ, Med Ctr, Dept Internal Med, Hackensack Meridian Sch Med, Seton Hall, Neptune, NJ USA
Rendell, M:
Rose Salter Med Res Fdn, Newport Coast, CA 92657 USA
Varon, J:
Univ Texas Houston, Sch Med, United Mem Med Ctr, Houston, TX USA
Dube, M:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Nanda, N:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
In, G:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Arkfeld, D:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Chaudhary, P:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Campese, VM:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Hanna, DL:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Sawcer, DE:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Ehresmann, G:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Peng, DV:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Smogorewski, M:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Armstrong, A:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Dasgupta, R:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Sattler, F:
Eastern Virginia Med Sch, Pulm & Crit Care Med, Dept Internal Med, Norfolk, VA 23501 USA
Brennan-Rieder, D:
Corona Tracker Community Res Grp, Victoriaville, PQ, Canada
Mussini, C:
Univ Modena & Reggio Emilia, Dept Infect Dis, Modena, Italy
:
Hosp Badalona Germans Trias & Pujol, Dept Internal Med, Badalona, Spain
Soriano, V:
UNIR Hlth Sci Sch & Med Ctr, Ctr Med, Madrid, Spain
Peschanski, N:
Univ Rennes, Dept Emergency Med, Rennes, France
Hayem, G:
Hop Paris St Joseph, Dept Rheumatol, Paris, France
Confalonieri, M:
Azienda Osped Univ Trieste, Dept Resp Dis, Trieste, Italy
Piccirillo, MC:
Fdn G Pascale, IRCCS, Ist Nazl Tumori, Dept Oncol, Naples, Italy
Lobo-Ferreira, A:
Univ Porto, Fac Med, Unidade Invest Cardiovasc Unic, Ctr Hosp Univ Sao Joao, Porto, Portugal
Hosp Rainha Santa Isabel, Marco De Canaveses, Portugal
Rivero, IB:
Ctr Genet Engn & Biotechnol, Dept Clin Invest, Havana, Cuba
Turkia, M:
Qualitat Res, Helsinki, Finland
Vingevoll, EH:
Volda Hosp HMR, Dept Anesthesiol, Volda, Norway
Griffin, D:
Rocky Mt Reg Vet Affairs Med Ctr, Dept Internal Med, Aurora, CO USA
Univ Colorado, Anschutz Med Campus, Aurora, CO USA
Columbia Univ, Coll Phys & Surg, ProHEALTH, Dept Internal Med, New York, NY 10027 USA
Columbia Univ, Coll Phys & Surg, ProHEALTH, Dept Biochem & Mol Biophys, New York, NY 10027 USA
Hung, IF:
Rocky Mt Reg Vet Affairs Med Ctr, Dept Internal Med, Aurora, CO USA
Univ Colorado, Anschutz Med Campus, Aurora, CO USA
Bronze, Green Published
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