Mental disorders, psychopharmacological treatments, and mortality in 2150 COVID-19 Spanish inpatients
Por:
Diez-Quevedo, C, Iglesias-Gonzalez, M, Giralt-Lopez, M, Rangil, T, Sanagustin, D, Moreira, M, Lopez-Ramentol, M, Ibanez-Caparros, A, Loran, ME, Bustos-Cardona, T, Menendez-Cuinas, I, Mundo-Cid, P, Blanco-Presas, L, de Pablo, J and Cuevas-Esteban, J
Publicada:
1 jun 2021
Ahead of Print:
1 abr 2021
Resumen:
Objective To determine how mental disorders and psychopharmacological treatments before and during COVID-19 hospital admissions are related to mortality.
Methods Subjects included in the study were all adult patients with a diagnosis of COVID-19, confirmed clinically and by PCR, who were admitted to a tertiary university hospital in Badalona (Spain) between March 1 and November 17, 2020. Data were extracted anonymously from computerized clinical records.
Results 2,150 subjects were included, 57% males, mean age 61 years. History of mental disorders was registered in 957 (45%). Throughout admission, de novo diagnosis of mood or anxiety, stress, or adjustment disorder was made in 12% of patients without previous history. Delirium was diagnosed in 10% of cases. 1011 patients (47%) received a psychotropic prescription during admission (36% benzodiazepines, 22% antidepressants, and 21% antipsychotics). Mortality rate was 17%. Delirium during admission and history of mood disorder were independently associated with higher mortality risk (hazard ratios, 1.39 and 1.52 respectively), while previous year's treatments with anxiolytics/hypnotics and antidepressants were independently associated with lower mortality risk (hazard ratios, 0.47 and 0.43, respectively).
Conclusion Mental symptoms are very common in patients hospitalized for COVID-19 infection. Detecting, diagnosing, and treating them is key to determining the prognosis of the disease and functional recovery.
Filiaciones:
:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Bellaterra, Spain
Iglesias-Gonzalez, M:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Bellaterra, Spain
CIBERESP, Ctr Invest Biomed Red Epidemiol & Salud Publ, Madrid, Spain
Giralt-Lopez, M:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Bellaterra, Spain
:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Sanagustin, D:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Bellaterra, Spain
Moreira, M:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Bellaterra, Spain
Lopez-Ramentol, M:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Ibanez-Caparros, A:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Bellaterra, Spain
Loran, ME:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Bellaterra, Spain
Bustos-Cardona, T:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Bellaterra, Spain
Menendez-Cuinas, I:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Mundo-Cid, P:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Blanco-Presas, L:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Bellaterra, Spain
:
Hosp Badalona Germans Trias & Pujol, Psychiat Serv, IGTP Campus Can Ruti, Badalona, Spain
Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Bellaterra, Spain
CIBERSAM, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Green Published
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