COVID-19 Infection in Critically III Patients Carries a High Risk of Venous Thrombo-embolism
Por:
Bellmunt-Montoya, S, Riera, C, Gil, D, Rodriguez, M, Garcia-Reyes, M, Martinez-Carnovale, L, Marrero, C, Gil, M, Ruiz-Rodriguez, JC, Ferrer, R, de Nadal, M, Monreal, M and Llagostera, S
Publicada:
1 abr 2021
Ahead of Print:
1 abr 2021
Resumen:
Objective: The coronayirus disease of 2019 (COVID-19) due to SARS-CoV-2 infection has been found to cause an increased risk of venous thrombo-embolism (VTE). The aims of the study were to determine the frequency of VTE in critically ill patients with COVID-19 and its correlation with D dimer levels and pharmacological prophylaxis.
Methods: This was a cohort study of critically ill patients due to COVID-19. All patients admitted to the intensive care unit on the same day of April 2020 were selected, regardless of length of stay, and a single bilateral venous duplex ultrasound in the lower extremities was performed up to 72 hours later. Pulmonary embolism (PE) was diagnosed by computed tomography angiography. Asymptomatic and symptomatic VTE were registered, including pre-screening in hospital VTE. Characteristics of patients, blood test results, doses of thromboprophylaxis received, VTE events, and mortality after seven day follow up were recorded.
Results: A total of 230 critically ill patients were studied. The median intensive care unit stay of these patients was 12 days (interquartile range [IQR] 5 - 19 days). After seven days follow up, the frequency of patients with VTE, both symptomatic and asymptomatic, was 26.5% (95% confidence interval [CI] 21% - 32%) (69 events in 61 patients): 45 with DVT and 16 with PE (eight of them with concomitant DVT). The cumulative frequency of symptomatic VTE was 8.3% (95% CI 4.7% - 11.8%). D dimer values >= 1 500 ng/mL were diagnostic of VTE, with a sensitivity of 80% and a specificity of 42%. During follow up after screening, six patients developed new VTE. Three of them developed a recurrence after a DVT diagnosed at screening, despite receiving therapeutic doses of heparin. Mortality rates at seven day follow up were the same for those with (6.6%) and without (5.3%) VTE.
Conclusion: Patients with severe COVID-19 infection are at high risk of VTE, and further new symptomatic VTE events and recurrence can occur despite anticoagulation. The prophylactic anticoagulant dose may need to be increased in patients with a low risk of bleeding.
Filiaciones:
Bellmunt-Montoya, S:
Univ Autonoma Barcelona UAB, Hosp Univ Vall dHebron, Vall dHebron Inst Recerca VHIR, Angiol & Vasc Surg Dept, Barcelona, Spain
Riera, C:
Hosp Badalona Germans Trias & Pujol, Angiol & Vasc Surg Dept, Barcelona, Spain
Gil, D:
Univ Autonoma Barcelona UAB, Hosp Univ Vall dHebron, Vall dHebron Inst Recerca VHIR, Angiol & Vasc Surg Dept, Barcelona, Spain
Rodriguez, M:
Hosp Badalona Germans Trias & Pujol, Angiol & Vasc Surg Dept, Barcelona, Spain
Garcia-Reyes, M:
Univ Autonoma Barcelona UAB, Hosp Univ Vall dHebron, Vall dHebron Inst Recerca VHIR, Angiol & Vasc Surg Dept, Barcelona, Spain
:
Hosp Badalona Germans Trias & Pujol, Angiol & Vasc Surg Dept, Barcelona, Spain
Marrero, C:
Univ Autonoma Barcelona UAB, Hosp Univ Vall dHebron, Vall dHebron Inst Recerca VHIR, Angiol & Vasc Surg Dept, Barcelona, Spain
Gil, M:
Hosp Badalona Germans Trias & Pujol, Angiol & Vasc Surg Dept, Barcelona, Spain
Ruiz-Rodriguez, JC:
Univ Autonoma Barcelona UAB, Hosp Univ Vall dHebron, Vall dHebron Inst Recerca VHIR, Intens Care Dept, Barcelona, Spain
Ferrer, R:
Univ Autonoma Barcelona UAB, Hosp Univ Vall dHebron, Vall dHebron Inst Recerca VHIR, Intens Care Dept, Barcelona, Spain
de Nadal, M:
Univ Autonoma Barcelona UAB, Hosp Univ Vall dHebron, Vall dHebron Inst Recerca VHIR, Anaesthesiol, Barcelona, Spain
:
Hosp Badalona Germans Trias & Pujol, Internal Med Dept, Barcelona, Spain
:
Hosp Badalona Germans Trias & Pujol, Angiol & Vasc Surg Dept, Barcelona, Spain
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