Lack of expression of LMO2 clone SP51 identifies MYC rearrangements in aggressive large B-cell lymphomas
Por:
Vazquez, I, Papaleo, N, Lop, J, Puiggros, A, Sanchez-Gonzalez, B, Diez-Feijoo, R, Gimeno, E, Andrade-Campos, M, Salar, A, Espinet, B, Salido, M, Tapia, G, Carreras, J, Ferrer, A, Arenillas, L, Calvo, X and Colomo, L
Publicada:
1 dic 2021
Ahead of Print:
1 abr 2021
Resumen:
MYC rearrangements (MYC-R) confer unfavorable prognosis to large B-cell lymphomas (LBCL). Because of the low incidence of such genetic alteration, surrogates to screen MYC-R may be useful in daily practice. Previous studies suggested that clone 1A9-1 of LMO2 loss may be a good predictor for the presence of MYC-R in LBCL. The present study examines the utility of LMO2 clone SP51. For this purpose, we have analyzed 20 Burkitt lymphomas and 325 LBCL. Among them, 245 cases were studied prospectively using whole tissue sections, and 100 retrospectively by tissue microarrays. The cohort of CD10-positive prospective cases achieved the best results. Lack of LMO2 SP51 expression predicted the presence of MYC-R with high specificity, accuracy, positive and negative predictive value (PPV/NPV), and positive and negative likelihood ratios (PLR/NLR). Compared with MYC protein expression, LMO2 SP51 obtained significantly higher specificity, accuracy, PPV, and PLR (94%, 91%, 85%, and 14.33 vs 73%, 77%, 56%, and 3.26, respectively), and similar NPV and NLR (92% and 0.22 vs 95% and 0.12). Compared with LMO2 clone 1A9-1, the sensitivity of LMO2 SP51 was lower (79% vs 89%). We conclude that LMO2 SP51 may be a useful marker to screen MYC-R in CD10-positive LBCL.
Filiaciones:
Vazquez, I:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Pathol, Barcelona, Spain
Univ Autonoma Barcelona, Dept Ciencies Morfol, Barcelona, Spain
Papaleo, N:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Pathol, Barcelona, Spain
Consorci Hosp Parc Tauli, Dept Pathol, Sabadell, Spain
Univ Pompeu Fabra, Dept Hlth & Expt Sci, Barcelona, Spain
Lop, J:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Pathol, Barcelona, Spain
Puiggros, A:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Pathol, Barcelona, Spain
Sanchez-Gonzalez, B:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Hematol, Barcelona, Spain
Diez-Feijoo, R:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Hematol, Barcelona, Spain
Gimeno, E:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Hematol, Barcelona, Spain
Andrade-Campos, M:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Hematol, Barcelona, Spain
Salar, A:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Hematol, Barcelona, Spain
Espinet, B:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Pathol, Barcelona, Spain
Salido, M:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Pathol, Barcelona, Spain
:
Hosp Badalona Germans Trias & Pujol, Inst Germans Trias & Pujol IGTP, Dept Pathol, Badalona, Spain
Carreras, J:
Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa, Japan
Ferrer, A:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Pathol, Barcelona, Spain
Univ Pompeu Fabra, Dept Hlth & Expt Sci, Barcelona, Spain
Arenillas, L:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Pathol, Barcelona, Spain
Calvo, X:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Pathol, Barcelona, Spain
Colomo, L:
Hosp Mar, Inst Hosp Mar Invest Med IMIM, Dept Pathol, Barcelona, Spain
Univ Pompeu Fabra, Dept Hlth & Expt Sci, Barcelona, Spain
|