Multifaceted Roles of CD5L in Infectious and Sterile Inflammation
Por:
Sanchez-Moral, L, Rafols, N, Martori, C, Paul, T, Tellez, E and Sarrias, MR
Publicada:
1 abr 2021
Ahead of Print:
15 abr 2021
Resumen:
CD5L, a protein expressed and secreted mainly by macrophages, is emerging as a critical immune effector. In addition to its well-defined function as an anti-apoptotic protein, research over the last decade has uncovered additional roles that range from pattern recognition to autophagy, cell polarization, and the regulation of lipid metabolism. By modulating all these processes, CD5L plays a key role in highly prevalent diseases that develop by either acute or chronic inflammation, including several infectious, metabolic, and autoimmune conditions. In this review, we summarize the current knowledge of CD5L and focus on the relevance of this protein during infection- and sterile-driven inflammatory pathogenesis, highlighting its divergent roles in the modulation of inflammation.
Filiaciones:
:
Hlth Res Inst Germans Trias & Pujol, Innate Immun Grp, Ctra Can Ruti Cami Les Escoles S-N, Badalona 08916, Spain
Rafols, N:
Hlth Res Inst Germans Trias & Pujol, Innate Immun Grp, Ctra Can Ruti Cami Les Escoles S-N, Badalona 08916, Spain
Martori, C:
Hlth Res Inst Germans Trias & Pujol, Innate Immun Grp, Ctra Can Ruti Cami Les Escoles S-N, Badalona 08916, Spain
:
Hlth Res Inst Germans Trias & Pujol, Innate Immun Grp, Ctra Can Ruti Cami Les Escoles S-N, Badalona 08916, Spain
:
Hlth Res Inst Germans Trias & Pujol, Innate Immun Grp, Ctra Can Ruti Cami Les Escoles S-N, Badalona 08916, Spain
:
Hlth Res Inst Germans Trias & Pujol, Innate Immun Grp, Ctra Can Ruti Cami Les Escoles S-N, Badalona 08916, Spain
Network Biomed Res Hepat & Digest Dis CIBERehd, Madrid 28029, Spain
Green Published, gold
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