White adipose tissue dysfunction in obesity and aging
Por:
Reyes-Farias, M, Fos-Domenech, J, Serra, D, Herrero, L and Sanchez-Infantes, D
Publicada:
1 oct 2021
Ahead of Print:
1 ago 2021
Resumen:
Both obesity and aging are associated with the development of metabolic diseases such as type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose tissue is one of the mechanisms implicated in the progression of these diseases. Obesity and aging trigger adipose tissue alterations that ultimately lead to a pro-inflammatory phenotype of the adipose tissue-resident immune cells. Obesity and aging also share other features such as a higher visceral vs. subcutaneous adipose tissue ratio and a decreased lifespan. Here, we review the common characteristics of obesity and aging and the alterations in white adipose tissue and resident immune cells. We focus on the adipose tissue metabolic derangements in obesity and aging such as inflammation and adipose tissue remodeling.
Filiaciones:
Reyes-Farias, M:
Germans Trias & Pujol Res Inst, Dept Endocrinol & Nutr, Barcelona, Spain
Univ Barcelona, Inst Biomed Univ Barcelona IBUB, Sch Pharm & Food Sci, Dept Biochem & Physiol, E-08028 Barcelona, Spain
Fos-Domenech, J:
Univ Barcelona, Inst Biomed Univ Barcelona IBUB, Sch Pharm & Food Sci, Dept Biochem & Physiol, E-08028 Barcelona, Spain
Serra, D:
Univ Barcelona, Inst Biomed Univ Barcelona IBUB, Sch Pharm & Food Sci, Dept Biochem & Physiol, E-08028 Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, E-28029 Madrid, Spain
Herrero, L:
Univ Barcelona, Inst Biomed Univ Barcelona IBUB, Sch Pharm & Food Sci, Dept Biochem & Physiol, E-08028 Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, E-28029 Madrid, Spain
:
Germans Trias & Pujol Res Inst, Dept Endocrinol & Nutr, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, E-28029 Madrid, Spain
Univ Rey Juan Carlos URJC, Dept Hlth Sci, Campus Alcorcon, E-28922 Madrid, Spain
hybrid
|