Histone Modifications and Their Targeting in Lymphoid Malignancies
Por:
Fernandez-Serrano, M, Winkler, R, Santos, JC, Le Pannerer, MM, Buschbeck, M and Roue, G
Publicada:
1 ene 2022
Ahead of Print:
27 dic 2021
Resumen:
In a wide range of lymphoid neoplasms, the process of malignant transformation is associated with somatic mutations in B cells that affect the epigenetic machinery. Consequential alterations in histone modifications contribute to disease-specific changes in the transcriptional program. Affected genes commonly play important roles in cell cycle regulation, apoptosis-inducing signal transduction, and DNA damage response, thus facilitating the emergence of malignant traits that impair immune surveillance and favor the emergence of different B-cell lymphoma subtypes. In the last two decades, the field has made a major effort to develop therapies that target these epigenetic alterations. In this review, we discuss which epigenetic alterations occur in B-cell non-Hodgkin lymphoma. Furthermore, we aim to present in a close to comprehensive manner the current state-of-the-art in the preclinical and clinical development of epigenetic drugs. We focus on therapeutic strategies interfering with histone methylation and acetylation as these are most advanced in being deployed from the bench-to-bedside and have the greatest potential to improve the prognosis of lymphoma patients.
Filiaciones:
:
Josep Carreras Leukaemia Res Inst IJC, Lymphoma Translat Grp, Badalona 08916, Spain
Autonomous Univ Barcelona, Dept Biochem & Mol Biol, Barcelona 08014, Spain
:
Josep Carreras Leukaemia Res Inst IJC, Chromatin Metab & Cell Fate Grp, Badalona 08916, Spain
:
Josep Carreras Leukaemia Res Inst IJC, Lymphoma Translat Grp, Badalona 08916, Spain
:
Josep Carreras Leukaemia Res Inst IJC, Chromatin Metab & Cell Fate Grp, Badalona 08916, Spain
:
Josep Carreras Leukaemia Res Inst IJC, Chromatin Metab & Cell Fate Grp, Badalona 08916, Spain
Germans Trias & Pujol Res Inst IGTP, Program Personalized & Predict Med Canc, Badalona 08916, Spain
:
Josep Carreras Leukaemia Res Inst IJC, Lymphoma Translat Grp, Badalona 08916, Spain
Autonomous Univ Barcelona, Dept Biochem & Mol Biol, Barcelona 08014, Spain
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