Are there differences by sex in lung cancer characteristics at diagnosis? -a nationwide study
Por:
Ruano-Ravina, A, Provencio, M, de Juan, VC, Carcereny, E, Estival, A, Rodriguez-Abreu, D, Benitez, G, Lopez-Castro, R, Belver, M, Guirado-Risueno, M, Guirao-Rubio, C, Blasco, A, Massuti, B, Ortega, AL, Cobo, M, Mosquera-Martinez, J, de la Rosa, CA, Bosch-Barrera, J, Sanchez-Gastaldo, A, Morillo, ED, Juan, O, Domine, M, Trigo, JM, Corbacho, DP and Oramas, J
Publicada:
1 oct 2021
Resumen:
Background: Lung cancer causes approximately 25% of all cancer deaths. Despite its relevance, few studies have analyzed differences by sex at the time of diagnosis in terms of symptoms, stage, age or smoking status. We aim to assess if there are differences between men and women on these characteristics at diagnosis. Methods: We analyzed the Thoracic Tumour Registry (TTR), sponsored by the Spanish Lung Cancer Group using a case-series design. This is a nationwide registry of lung cancer cases which started recruitment in 2016. For each case included, clinicians fulfilled an electronic record registering demographic data, symptoms, exposure to lung cancer risk factors, and treatment received in detail. We compared men and women using descriptive statistics. Results: A total of 13,590 participants took part in this study, 25.6% women. Women were 4 years younger than men (64 vs. 69), and men had smoked more frequently. Adenocarcinoma was the most frequent histological type in both sexes. Stage IV at diagnosis was 50.8% in women compared to 43.6% in men. Weight loss/anorexia/asthenia was the most frequent symptom in both sexes and there were no differences in the number of symptoms at diagnosis. There were no relevant differences in the frequency or number of symptoms by sex when non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) were analyzed separately. Smoking status did not appear to cause different lung cancer presentation in men compared to women. Conclusions: There seems to be no differences in lung cancer characteristics by sex at the time at diagnosis on stage, specific symptoms or number of symptoms.
Filiaciones:
Ruano-Ravina, A:
Univ Santiago de Compostela, Dept Prevent Med & Publ Hlth, Santiago De Compostela, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Consortium Biomed Res Epidemiol & Publ Hlth, Madrid, Spain
Inst Invest Sanitaria Santiago de Compostela IDIS, Hlth Res Inst Santiago de Compostela, Santiago De Compostela, Spain
Provencio, M:
Puerta Hierro Univ Hosp, Dept Oncol, Madrid, Spain
de Juan, VC:
Puerta Hierro Univ Hosp, Dept Oncol, Madrid, Spain
:
Badalona Germans Trias I Pujol Hosp B ARGO Grp, Catalan Inst Oncol, Med Oncol Dept, Barcelona, Spain
:
Badalona Germans Trias I Pujol Hosp B ARGO Grp, Catalan Inst Oncol, Med Oncol Dept, Barcelona, Spain
Rodriguez-Abreu, D:
Hosp Insular Gran Canaria, Las Palmas Gran Canaria, Spain
Benitez, G:
Hosp Insular Gran Canaria, Las Palmas Gran Canaria, Spain
Lopez-Castro, R:
Hosp Clin Univ Valladolid, Secc Oncol Med, Serv Oncol, Valladolid, Spain
Belver, M:
Hosp Clin Univ Valladolid, Secc Oncol Med, Serv Oncol, Valladolid, Spain
Guirado-Risueno, M:
Hosp Elche, Elche, Spain
Guirao-Rubio, C:
Hosp Elche, Elche, Spain
Blasco, A:
Hosp Gen Valencia, Valencia, Spain
Massuti, B:
Hosp Univ Gen Alicante, Alicante, Spain
Ortega, AL:
Complejo Hosp Jaen, Serv Oncol Med, Jaen, Spain
Cobo, M:
IBIMA, Hosp Univ Reg & Virgen Victoria, Unidad Gest Clin Interctr Oncol Med, Malaga, Spain
Mosquera-Martinez, J:
Hosp Univ A Coruna, La Coruna, Spain
de la Rosa, CA:
Clin San Carlos Hosp, Dept Oncol, Madrid, Spain
Bosch-Barrera, J:
Girona Biomed Res Inst IDIBGI, Girona, Spain
Univ Girona, Med Sch, Dept Med Sci, Girona, Spain
Hosp Univ Dr Josep Trueta, Catalan Inst Oncol, Med Oncol, Girona, Catalonia, Spain
Sanchez-Gastaldo, A:
Hosp Virgen Rocio, Dept Oncol, Seville, Spain
Morillo, ED:
Hosp Salamanca, Dept Oncol, Slamanca, Spain
Juan, O:
Hosp Univ & Politecn La Fe, Serv Oncol Med, Valencia, Spain
Domine, M:
Hosp Jimenez Diaz, Madrid, Spain
Trigo, JM:
Hosp Univ Virgen Victoria, Serv Oncol Med, Malaga, Spain
Hosp Univ Virgen Victoria, Unidad Fases 1, Malaga, Spain
Corbacho, DP:
Hosp Univ Alvaro Cunqueiro, Vigo, Spain
Oramas, J:
Hosp Univ Canarias, Santa Cruz De Tenerife, Spain
Green Published, gold
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