KRAS and MET in non-small-cell lung cancer: two of the new kids on the 'drivers' block
Por:
Garcia-Robledo, JE, Rosell, R, Ruiz-Patino, A, Sotelo, C, Arrieta, O, Zatarain-Barron, L, Ordonez, C, Jaller, E, Rojas, L, Russo, A, de Miguel-Perez, D, Rolfo, C and Cardona, AF
Publicada:
1 ene 2022
Resumen:
Non-small-cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced to identify various critical oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted therapies against these oncogenes in the hope of personalized treatment based on the tumor's molecular genomics. This review presents a comprehensive review of the biology, new therapeutic interventions, and resistance patterns of two well-defined subgroups, tumors with KRAS and MET alterations. We also discuss the status of molecular testing practices for these two key oncogenic drivers, considering the progressive introduction of next-generation sequencing (NGS) and RNA sequencing in regular clinical practice.
Filiaciones:
Garcia-Robledo, JE:
Mayo Clin, Div Hematol Oncol, Scottsdale, AZ USA
:
Quiron Dexeus Univ Inst, Canc Biol & Precis Med Program, Germans Trias & Pujol Res Inst IGTPI, Dr Rosell Oncol Inst IOR, Barcelona, Spain
Ruiz-Patino, A:
Fdn Clin & Appl Canc Res FICMAC, Bogota, Colombia
Univ el Bosque, Mol Oncol & Biol Syst Res Grp FOX G, Bogota, Colombia
Sotelo, C:
Fdn Clin & Appl Canc Res FICMAC, Bogota, Colombia
Univ el Bosque, Mol Oncol & Biol Syst Res Grp FOX G, Bogota, Colombia
Arrieta, O:
Natl Canc Inst INCan, Thorac Oncol Unit, Mexico City, DF, Mexico
Natl Canc Inst INCan, Personalized Oncol Lab, Mexico City, DF, Mexico
Zatarain-Barron, L:
Natl Canc Inst INCan, Thorac Oncol Unit, Mexico City, DF, Mexico
Natl Canc Inst INCan, Personalized Oncol Lab, Mexico City, DF, Mexico
Ordonez, C:
Fdn Clin & Appl Canc Res FICMAC, Bogota, Colombia
Univ el Bosque, Mol Oncol & Biol Syst Res Grp FOX G, Bogota, Colombia
Jaller, E:
Univ El Bosque, Dept Internal Med, Bogota, Colombia
Rojas, L:
Fdn Clin & Appl Canc Res FICMAC, Bogota, Colombia
Clin Colsanitas, Dept Clin Oncol, Bogota, Colombia
Clin Country, Clin & Translat Oncol Grp, Bogota, Colombia
Russo, A:
AO Papardo, Med Oncol Unit, Messina, Italy
Univ Maryland, Sch Med, Marlene & Stewart Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA
de Miguel-Perez, D:
Univ Maryland, Sch Med, Marlene & Stewart Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA
Rolfo, C:
Univ Maryland, Sch Med, Marlene & Stewart Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA
Cardona, AF:
Luis Carlos Sarmiento Angulo Canc Treatment & Res, Direct Res & Educ, Bogota, Colombia
Fdn Clin & Appl Canc Res FICMAC, Bogota, Colombia
Univ el Bosque, Mol Oncol & Biol Syst Res Grp FOX G, Bogota, Colombia
gold, Green Published
|