Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health
Por:
Ribo, S, Sanchez-Infantes, D, Martinez-Guino, L, Garcia-Mantrana, I, Ramon-Krauel, M, Tondo, M, Arning, E, Nofrarias, M, Osorio-Conles, O, Fernandez-Perez, A, Gonzalez-Torres, P, Cebria, J, Gavalda-Navarro, A, Chenoll, E, Isganaitis, E, Villarroya, F, Vallejo, M, Segales, J, Jimenez-Chillaron, JC, Bottiglieri, T, Demerath, EW, Fields, DA, Collado, MC and Lerin, C
Publicada:
31 mar 2021
Resumen:
Accelerated postnatal growth is a potentially modifiable risk factor for future obesity. To study how specific breast milk components contribute to early growth and obesity risk, we quantified one-carbon metabolism-related metabolites in human breast milk and found an inverse association between milk betaine content and infant growth. This association was replicated in an independent and geographically distinct cohort. To determine the potential role of milk betaine in modulating offspring obesity risk, we performed maternal betaine supplementation experiments in mice. Higher betaine intake during lactation increased milk betaine content in dams and led to lower adiposity and improved glucose homeostasis throughout adulthood in mouse offspring. These effects were accompanied by a transient increase in Akkermansia spp. abundance in the gut during early life and a long-lasting increase in intestinal goblet cell number. The link between breast milk betaine and Akkermansia abundance in the gut was also observed in humans, as infants exposed to higher milk betaine content during breastfeeding showed higher fecal Akkermansia muciniphila abundance. Furthermore, administration of A. muciniphila to mouse pups during the lactation period partially replicated the effects of maternal breast milk betaine, including increased intestinal goblet cell number, lower adiposity, and improved glucose homeostasis during adulthood. These data demonstrate a link between breast milk betaine content and long-term metabolic health of offspring.
Filiaciones:
Ribo, S:
Inst Recerca St Joan Deu, Endocrinol Dept, Barcelona 08950, Spain
:
Inst Recerca St Joan Deu, Endocrinol Dept, Barcelona 08950, Spain
Inst Recerca Germans Trias & Pujol, Dept Endocrinol & Nutr, Barcelona 08916, Spain
CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain
Martinez-Guino, L:
Inst Recerca St Joan Deu, Endocrinol Dept, Barcelona 08950, Spain
Garcia-Mantrana, I:
CNR, Dept Biotechnol, Inst Agrochem & Food Technol, IATA,CSIC, Valencia 46980, Spain
Ramon-Krauel, M:
Inst Recerca St Joan Deu, Endocrinol Dept, Barcelona 08950, Spain
Tondo, M:
Baylor Scott & White Res Inst, Inst Metab Dis, Dallas, TX 75204 USA
Arning, E:
Baylor Scott & White Res Inst, Inst Metab Dis, Dallas, TX 75204 USA
Nofrarias, M:
UAB, Ctr Recerca Sanitat Anim CReSA, IRTA, Campus Univ Autonoma Barcelona, Bellaterra 08193, Spain
Osorio-Conles, O:
Inst Recerca St Joan Deu, Endocrinol Dept, Barcelona 08950, Spain
Fernandez-Perez, A:
Univ Autonoma Madrid CSIC UAM, Inst Invest Biomed Alberto Sols, Consejo Super Invest Cient, Madrid 28029, Spain
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid 28029, Spain
Ctr Desarrollo Tecnol & Ind CDTI, Madrid 28001, Spain
Gonzalez-Torres, P:
Ctr Genom Regulat CRG, Bioinformat & Genom Program, Barcelona 08003, Spain
Cebria, J:
Inst Recerca St Joan Deu, Endocrinol Dept, Barcelona 08950, Spain
Gavalda-Navarro, A:
CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain
Univ Barcelona, Inst Biomed Univ Barcelona IBUB, Dept Bioquim & Biomed Mol, Barcelona 08028, Spain
Inst Recerca St Joan Deu, Barcelona 08950, Spain
Chenoll, E:
Biopolis SL ADM, Paterna 46980, Spain
Isganaitis, E:
Harvard Med Sch, Res Div, Joslin Diabet Ctr, Boston, MA 02215 USA
Villarroya, F:
CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain
Univ Barcelona, Inst Biomed Univ Barcelona IBUB, Dept Bioquim & Biomed Mol, Barcelona 08028, Spain
Inst Recerca St Joan Deu, Barcelona 08950, Spain
Vallejo, M:
Univ Autonoma Madrid CSIC UAM, Inst Invest Biomed Alberto Sols, Consejo Super Invest Cient, Madrid 28029, Spain
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid 28029, Spain
Segales, J:
UAB, IRTA UAB, Ctr Recerca Sanitat Anim CReSA, Campus Univ Autonoma Barcelona, Bellaterra 08193, Spain
UAB, Dept Sanitat & Anat Anim, Fac Vet, Barcelona 08193, Spain
Jimenez-Chillaron, JC:
Inst Recerca St Joan Deu, Endocrinol Dept, Barcelona 08950, Spain
Bottiglieri, T:
Baylor Scott & White Res Inst, Inst Metab Dis, Dallas, TX 75204 USA
Demerath, EW:
Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN 55455 USA
Fields, DA:
Univ Oklahoma, Dept Pediat, Hlth Sci Ctr, Oklahoma City, OK 73104 USA
Collado, MC:
CNR, Dept Biotechnol, Inst Agrochem & Food Technol, IATA,CSIC, Valencia 46980, Spain
Lerin, C:
Inst Recerca St Joan Deu, Endocrinol Dept, Barcelona 08950, Spain
Green Accepted, Green Submitted
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