Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry
Por:
Perez-Zsolt, D, Erkizia, I, Pino, M, Garcia-Gallo, M, Martin, MT, Benet, S, Chojnacki, J, Fernandez-Figueras, MT, Guerrero, D, Urrea, V, Muniz-Trabudua, X, Kremer, L, Martinez-Picado, J and Izquierdo-Useros, N
Publicada:
1 sep 2019
Ahead of Print:
3 jun 2019
Resumen:
Several Ebola viruses cause outbreaks of lethal haemorrhagic fever in humans, but developing therapies tackle only Zaire Ebola virus. Dendritic cells (DCs) are targets of this infection in vivo. Here, we found that Ebola virus entry into activated DCs requires the sialic acid-binding Ig-like lectin 1 (Siglec-1/CD169), which recognizes sialylated gangliosides anchored to viral membranes. Blockage of the Siglec-1 receptor by anti-Siglec-1 monoclonal antibodies halted Ebola viral uptake and cytoplasmic entry, offering cross-protection against other ganglioside-containing viruses such as human immunodeficiency virus type 1.
Filiaciones:
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Pino, M:
irsiCaixa AIDS Res Inst, Badalona, Spain
Garcia-Gallo, M:
CSIC, Prot Tools Unit, Spanish Natl Ctr Biotechnol, Madrid, Spain
CSIC, Dept Immunol & Oncol, Spanish Natl Ctr Biotechnol, Madrid, Spain
Martin, MT:
CSIC, Prot Tools Unit, Spanish Natl Ctr Biotechnol, Madrid, Spain
CSIC, Dept Immunol & Oncol, Spanish Natl Ctr Biotechnol, Madrid, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
:
Hosp Univ Gen Catalunya, Dept Pathol, Grp Quiron Salud, Barcelona, Spain
Univ Int Catalunya, Barcelona, Spain
Inst Invest Ciencies Salut Germans Trias & Pujol, Badalona, Spain
Guerrero, D:
Hosp Badalona Germans Trias & Pujol, Otorhinolaryngol Dept, Badalona, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Kremer, L:
CSIC, Prot Tools Unit, Spanish Natl Ctr Biotechnol, Madrid, Spain
CSIC, Dept Immunol & Oncol, Spanish Natl Ctr Biotechnol, Madrid, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Univ Vic, Cent Univ Catalonia, Vic, Spain
Catalan Inst Res & Adv Studies, Barcelona, Spain
:
irsiCaixa AIDS Res Inst, Badalona, Spain
Inst Invest Ciencies Salut Germans Trias & Pujol, Badalona, Spain
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