Evolution of the gut microbiome following acute HIV-1 infection
Por:
Rocafort, M, Noguera-Julian, M, Rivera, J, Pastor, L, Guillen, Y, Langhorst, J, Parera, M, Mandomando, I, Carrillo, J, Urrea, V, Rodriguez, C, Casadella, M, Calle, ML, Clotet, B, Blanco, J, Naniche, D and Paredes, R
Publicada:
11 may 2019
Ahead of Print:
11 may 2019
Resumen:
BackgroundIn rhesus macaques, simian immunodeficiency virus infection is followed by expansion of enteric viruses but has a limited impact on the gut bacteriome. To understand the longitudinal effects of HIV-1 infection on the human gut microbiota, we prospectively followed 49 Mozambican subjects diagnosed with recent HIV-1 infection (RHI) and 54 HIV-1-negative controls for 9-18months and compared them with 98 chronically HIV-1-infected subjects treated with antiretrovirals (n = 27) or not (n = 71).ResultsWe show that RHI is followed by increased fecal adenovirus shedding, which persists during chronic HIV-1 infection and does not resolve with ART. Recent HIV-1 infection is also followed by transient non-HIV-specific changes in the gut bacterial richness and composition. Despite early resilience to change, an HIV-1-specific signature in the gut bacteriomefeaturing depletion of Akkermansia, Anaerovibrio, Bifidobacterium, and Clostridiumpreviously associated with chronic inflammation, CD8+ T cell anergy, and metabolic disorders, can be eventually identified in chronically HIV-1-infected subjects.ConclusionsRecent HIV-1 infection is associated with increased fecal shedding of eukaryotic viruses, transient loss of bacterial taxonomic richness, and long-term reductions in microbial gene richness. An HIV-1-associated microbiome signature only becomes evident in chronically HIV-1-infected subjects.
Filiaciones:
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IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
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IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
Univ Cent Catalunya, Univ Vic, C Sagrada Familia 7, Vic 08500, Catalonia, Spain
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IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Cent Catalunya, Univ Vic, C Sagrada Familia 7, Vic 08500, Catalonia, Spain
Pastor, L:
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona 08036, Catalonia, Spain
Univ Autonoma Barcelona, IGTP, Hosp Germans Trias & Pujol, Badalona 08916, Catalonia, Spain
CISM, Maputo 1929, Mozambique
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IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
Langhorst, J:
Univ Duisburg Essen, Integrat Gastroenterol, Kliniken Essen Mitte, Essen, Germany
Univ Duisburg Essen, Chair Integrat Med & Translat Gastroenterol, Klinikum Bamberg, Essen, Bavaria, Germany
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IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
Mandomando, I:
CISM, Maputo 1929, Mozambique
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IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
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IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
Rodriguez, C:
IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
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IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
Calle, ML:
Univ Cent Catalunya, Univ Vic, C Sagrada Familia 7, Vic 08500, Catalonia, Spain
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IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
Univ Cent Catalunya, Univ Vic, C Sagrada Familia 7, Vic 08500, Catalonia, Spain
Hosp Badalona Germans Trias & Pujol, Infect Dis Serv, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
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IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
Univ Cent Catalunya, Univ Vic, C Sagrada Familia 7, Vic 08500, Catalonia, Spain
Univ Autonoma Barcelona, IGTP, Hosp Germans Trias & Pujol, Badalona 08916, Catalonia, Spain
Naniche, D:
Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona 08036, Catalonia, Spain
CISM, Maputo 1929, Mozambique
:
IrsiCaixa AIDS Res Inst, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
Univ Autonoma Barcelona, Bellaterra 08193, Catalonia, Spain
Univ Cent Catalunya, Univ Vic, C Sagrada Familia 7, Vic 08500, Catalonia, Spain
Hosp Badalona Germans Trias & Pujol, Infect Dis Serv, Ctra Canyet S-N, Badalona 08916, Catalonia, Spain
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