Moving towards Personalized Medicine in Muscle-Invasive Bladder Cancer: Where Are We Now and Where Are We Going?
Por:
Pardo, JC, de Porras, VR, Plaja, A, Carrato, C, Etxaniz, O, Buisan, O and Font, A
Publicada:
1 sep 2020
Ahead of Print:
29 ago 2020
Resumen:
Neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy is the recommended treatment, with the highest level of evidence, for patients with muscle-invasive bladder cancer (MIBC). However, only a minority of patients receive this treatment, mainly due to patient comorbidities, the relatively small survival benefit, and the lack of predictive biomarkers to select those patients most likely to benefit from this multimodal approach. In addition, adjuvant chemotherapy has been recommended for patients with high-risk MIBC, although randomized trials have not provided conclusive evidence on the impact of this approach. At present, however, this situation is changing, largely due to our improved knowledge of the molecular biology of bladder cancer, which has enabled us to identify new prognostic and predictive biomarkers that can be used to select the most appropriate treatment for each patient. Moreover, new active treatments, especially immunotherapy, have shown promising results in the neoadjuvant setting. In addition, the gene expression profile of bladder tumors can be used to classify them into different subtypes, which correlate with specific clinical-pathological characteristics and with treatment response or resistance. Therefore, the main objective for the near future is to introduce these translational breakthroughs into routine clinical practice in order to personalize treatment for each patient.
Filiaciones:
:
Univ Hosp Germans Trias & Pujol, Catalan Inst Oncol, Dept Med Oncol, Ctra Can Ruti Cami De Les Escoles S-N, Badalona 08916, Spain
Catalan Inst Oncol, Badalona Appl Res Grp Oncol BARGO, Ctra Can Ruti Cami De Les Escoles S-N, Badalona 08916, Spain
:
Catalan Inst Oncol, Badalona Appl Res Grp Oncol BARGO, Ctra Can Ruti Cami De Les Escoles S-N, Badalona 08916, Spain
Germans Trias & Pujol Res Inst IGTP, Ctra Can Ruti Cami De Les Escoles S-N, Badalona 08916, Spain
Plaja, A:
Univ Hosp Germans Trias & Pujol, Catalan Inst Oncol, Dept Med Oncol, Ctra Can Ruti Cami De Les Escoles S-N, Badalona 08916, Spain
Catalan Inst Oncol, Badalona Appl Res Grp Oncol BARGO, Ctra Can Ruti Cami De Les Escoles S-N, Badalona 08916, Spain
:
Hosp Badalona Germans Trias & Pujol, Pathol Dept, Badalona 08916, Spain
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Univ Hosp Germans Trias & Pujol, Catalan Inst Oncol, Dept Med Oncol, Ctra Can Ruti Cami De Les Escoles S-N, Badalona 08916, Spain
Catalan Inst Oncol, Badalona Appl Res Grp Oncol BARGO, Ctra Can Ruti Cami De Les Escoles S-N, Badalona 08916, Spain
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Univ Hosp Germans Trias & Pujol, Urol Dept, Badalona 08916, Spain
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Univ Hosp Germans Trias & Pujol, Catalan Inst Oncol, Dept Med Oncol, Ctra Can Ruti Cami De Les Escoles S-N, Badalona 08916, Spain
Catalan Inst Oncol, Badalona Appl Res Grp Oncol BARGO, Ctra Can Ruti Cami De Les Escoles S-N, Badalona 08916, Spain
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