Relevance of Porcine Stroke Models to Bridge the Gap from Pre-Clinical Findings to Clinical Implementation
Por:
Melia-Sorolla, M, Castano, C, DeGregorio-Rocasolano, N, Rodriguez-Esparragoza, L, Divalos, A, Marti-Sistac, O and Gasull, T
Publicada:
1 sep 2020
Ahead of Print:
8 sep 2020
Resumen:
In the search of animal stroke models providing translational advantages for biomedical research, pigs are large mammals with interesting brain characteristics and wide social acceptance. Compared to rodents, pigs have human-like highly gyrencephalic brains. In addition, increasingly through phylogeny, animals have more sophisticated white matter connectivity; thus, ratios of white-to-gray matter in humans and pigs are higher than in rodents. Swine models provide the opportunity to study the effect of stroke with emphasis on white matter damage and neuroanatomical changes in connectivity, and their pathophysiological correlate. In addition, the subarachnoid space surrounding the swine brain resembles that of humans. This allows the accumulation of blood and clots in subarachnoid hemorrhage models mimicking the clinical condition. The clot accumulation has been reported to mediate pathological mechanisms known to contribute to infarct progression and final damage in stroke patients. Importantly, swine allows trustworthy tracking of brain damage evolution using the same non-invasive multimodal imaging sequences used in the clinical practice. Moreover, several models of comorbidities and pathologies usually found in stroke patients have recently been established in swine. We review here ischemic and hemorrhagic stroke models reported so far in pigs. The advantages and limitations of each model are also discussed.
Filiaciones:
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Germans Trias & Pujol Res Inst, Dept Neurosci, Cellular & Mol Neurobiol Res Grp, Badalona 08916, Spain
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Hosp Badalona Germans Trias & Pujol, Dept Neurosci, Neurointervent Radiol Unit, Badalona 08916, Spain
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Germans Trias & Pujol Res Inst, Dept Neurosci, Cellular & Mol Neurobiol Res Grp, Badalona 08916, Spain
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Hosp Badalona Germans Trias & Pujol, Dept Neurol, Stroke Unit, Badalona 08916, Spain
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Hosp Badalona Germans Trias & Pujol, Dept Neurol, Stroke Unit, Badalona 08916, Spain
Marti-Sistac, O:
Germans Trias & Pujol Res Inst, Dept Neurosci, Cellular & Mol Neurobiol Res Grp, Badalona 08916, Spain
Univ Autonoma Barcelona, Dept Cellular Biol Physiol & Immunol, Bellaterra 08916, Spain
Fdn Inst Invest Ciencies Salut Germans Tria & Puj, Carretera Canyet,Canal Escoles S-N,Edifico Mar, Bellaterra 08916, Spain
:
Germans Trias & Pujol Res Inst, Dept Neurosci, Cellular & Mol Neurobiol Res Grp, Badalona 08916, Spain
Fdn Inst Invest Ciencies Salut Germans Tria & Puj, Carretera Canyet,Canal Escoles S-N,Edifico Mar, Bellaterra 08916, Spain
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