Loss of HDAC11 accelerates skeletal muscle regeneration
Por:
Nunez-Alvarez, Y, Hurtado, E, Munoz, M, Garcia-Tunon, I, Rech, GE, Pluvinet, R, Sumoy, L, Pendas, AM, Peinado, MA and Suelves, M
Publicada:
1 feb 2021
Ahead of Print:
1 jul 2020
Resumen:
Histone deacetylase 11 (HDAC11) is the latest identified member of the histone deacetylase family of enzymes. It is highly expressed in brain, heart, testis, kidney, and skeletal muscle, although its role in these tissues is poorly understood. Here, we investigate for the first time the consequences of HDAC11 genetic impairment on skeletal muscle regeneration, a process principally dependent on its resident stem cells (satellite cells) in coordination with infiltrating immune cells and stromal cells. Our results show that HDAC11 is dispensable for adult muscle growth and establishment of the satellite cell population, while HDAC11 deficiency advances the regeneration process in response to muscle injury. This effect is not caused by differences in satellite cell activation or proliferation upon injury, but rather by an enhanced capacity of satellite cells to differentiate at early regeneration stages in the absence of HDAC11. Infiltrating HDAC11-deficient macrophages could also contribute to this accelerated muscle regenerative process by prematurely producing high levels of IL-10, a cytokine known to promote myoblast differentiation. Altogether, our results show that HDAC11 depletion advances skeletal muscle regeneration and this finding may have potential implications for designing new strategies for muscle pathologies coursing with chronic damage. Database Data were deposited in NCBI's Gene Expression Omnibus accessible through GEO Series accession number .
Filiaciones:
Nunez-Alvarez, Y:
Germans Trias & Pujol Hlth Sci Res Inst IGTP, Program Predict & Personalized Med Canc, Can Ruti Campus, Badalona, Spain
IGH UMR9002 CNRS UM, Inst Human Genet, F-3439 Montpellier 5, France
:
Germans Trias & Pujol Hlth Sci Res Inst IGTP, Program Predict & Personalized Med Canc, Can Ruti Campus, Badalona, Spain
:
Germans Trias & Pujol Hlth Sci Res Inst IGTP, Program Predict & Personalized Med Canc, Can Ruti Campus, Badalona, Spain
Garcia-Tunon, I:
CSIC USAL, Inst Cellular & Mol Biol Canc, Salamanca, Spain
Rech, GE:
Germans Trias & Pujol Hlth Sci Res Inst IGTP, Program Predict & Personalized Med Canc, Can Ruti Campus, Badalona, Spain
CSIC UPF, Inst Evolutionary Biol, Barcelona, Spain
:
Germans Trias & Pujol Hlth Sci Res Inst IGTP, Program Predict & Personalized Med Canc, Can Ruti Campus, Badalona, Spain
:
Germans Trias & Pujol Hlth Sci Res Inst IGTP, Program Predict & Personalized Med Canc, Can Ruti Campus, Badalona, Spain
Pendas, AM:
CSIC USAL, Inst Cellular & Mol Biol Canc, Salamanca, Spain
:
Germans Trias & Pujol Hlth Sci Res Inst IGTP, Program Predict & Personalized Med Canc, Can Ruti Campus, Badalona, Spain
:
Germans Trias & Pujol Hlth Sci Res Inst IGTP, Program Predict & Personalized Med Canc, Can Ruti Campus, Badalona, Spain
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