Cryptic Plasmodium chronic infections: was Maurizio Ascoli right?
Por:
Monteiro, W, Brito-Sousa, JD, Elizalde-Torrent, A, Botto-Menezes, C, Melo, GC, Fernandez-Becerra, C, Lacerda, M and del Portillo, HA
Publicada:
30 dic 2020
Ahead of Print:
30 nov 2020
Resumen:
Cryptic Plasmodium niches outside the liver possibly represent a major source of hypnozoite-unrelated recrudescences in malaria. Maurizio Ascoli, an Italian physician and scientist, suggested that infection was maintained as a result of the persistence of endoerythrocytic parasites in the circulatory bed of some internal organs, mainly the spleen. This would explain a proportion of the recurrences in patients, regardless of the Plasmodium species. Ascoli proposed a method that included the co-administration of adrenaline, in order to induce splenic contraction, and quinine to clear expelled forms in major vessels. Driven by controversy regarding safety and effectiveness, along with the introduction of new drugs, the Ascoli method was abandoned and mostly forgotten by the malaria research community. To date, however, the existence of cryptic parasites outside the liver is gaining supportive data. This work is a historical retrospective of cryptic malaria infections and the Ascoli method, highlighting key knowledge gaps regarding these possible parasite reservoirs.
Filiaciones:
Monteiro, W:
Fundacao Med Trop Dr Heitor Vieira Dourado FMT HV, Manaus, Amazonas, Brazil
Univ Estado Amazonas UEA, Manaus, Amazonas, Brazil
Brito-Sousa, JD:
Fundacao Med Trop Dr Heitor Vieira Dourado FMT HV, Manaus, Amazonas, Brazil
Univ Estado Amazonas UEA, Manaus, Amazonas, Brazil
:
Univ Barcelona, Hosp Clin, ISGlobal, Barcelona, Spain
Inst Invest Germans Trias & Pujol IGTP, Barcelona, Spain
IrsiCaixa AIDS Res Inst, Badalona, Catalonia, Spain
Botto-Menezes, C:
Fundacao Med Trop Dr Heitor Vieira Dourado FMT HV, Manaus, Amazonas, Brazil
Univ Estado Amazonas UEA, Manaus, Amazonas, Brazil
Melo, GC:
Fundacao Med Trop Dr Heitor Vieira Dourado FMT HV, Manaus, Amazonas, Brazil
Univ Estado Amazonas UEA, Manaus, Amazonas, Brazil
Fernandez-Becerra, C:
Univ Barcelona, Hosp Clin, ISGlobal, Barcelona, Spain
Inst Invest Germans Trias & Pujol IGTP, Barcelona, Spain
Lacerda, M:
Fundacao Med Trop Dr Heitor Vieira Dourado FMT HV, Manaus, Amazonas, Brazil
Fiocruz MS, Inst Leonidas & Maria Deane ILMD, Manaus, Amazonas, Brazil
:
Univ Barcelona, Hosp Clin, ISGlobal, Barcelona, Spain
Inst Invest Germans Trias & Pujol IGTP, Barcelona, Spain
Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain
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