Elevated Levels of Circulating miR-92a Are Associated with Impaired Glucose Homeostasis in Patients with Obesity and Correlate with Metabolic Status After Bariatric Surgery
Por:
Cereijo, R, Taxeras, SD, Piquer-Garcia, I, Pellitero, S, Martinez, E, Tarasco, J, Moreno, P, Balibrea, J, Puig-Domingo, M, Jimenez-Pavon, D, Lerin, C, Villarroya, F and Sanchez-Infantes, D
Publicada:
1 ene 2020
Resumen:
Introduction miRNAs are small non-coding RNAs, some of which are expressed in adipose tissues, are present in the circulation, and are regulated in obesity. Bariatric surgery (BS) has been proposed to lead to activation of brown adipose tissue, an effect that may be related to beneficial effects of BS on systemic metabolism. Here, we evaluated circulating levels of miR-92a and miR-99b, two miRNAs proposed as biomarkers of brown fat activity, in a cohort of patients with severe obesity before and after BS, and studied their potential relationship with BS-associated improvements in metabolic parameters. Methods Circulating levels of miR-92a and miR-99b were quantified in a cohort of 26 patients (age, 48 +/- 10 years; BMI, 45 +/- 7 kg/m(2)) before and 6 months after BS. Clinical parameters were determined at different time points and correlations among them were studied. Results Basal levels of miR-92a were significantly increased in patients with obesity relative to lean controls. Serum miR-92a levels were strongly reduced at 6 months after BS, reaching levels similar to those in controls. Serum miR-99b levels were unchanged in relation to both the obese condition and BS. Elevated levels of miR-92a were directly correlated with worsened glucose homeostasis parameters and poor BS outcome. Conclusions Our findings show that miR-92a is elevated in conditions of obesity, and its reduction after BS correlates with metabolic improvement. Further studies would be necessary to establish miR-92a as serum biomarker and potential predictor of the BS success in improving the metabolic status of patients with obesity.
Filiaciones:
Cereijo, R:
Univ Barcelona, Inst Biomed, Dept Biochem & Mol Biomed, Barcelona, Catalonia, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Barcelona, Catalonia, Spain
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Germans Trias & Pujol Res Inst, Campus Can Ruti,Carretera Can Ruti, Barcelona 08916, Spain
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Germans Trias & Pujol Res Inst, Campus Can Ruti,Carretera Can Ruti, Barcelona 08916, Spain
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Germans Trias & Pujol Res Inst, Campus Can Ruti,Carretera Can Ruti, Barcelona 08916, Spain
ISCIII, Biomed Res Ctr Red Fisiopatol Diabet & Enfermedad, Madrid, Spain
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Germans Trias & Pujol Res Inst, Campus Can Ruti,Carretera Can Ruti, Barcelona 08916, Spain
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Germans Trias & Pujol Res Inst, Campus Can Ruti,Carretera Can Ruti, Barcelona 08916, Spain
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Germans Trias & Pujol Res Inst, Campus Can Ruti,Carretera Can Ruti, Barcelona 08916, Spain
Balibrea, J:
Vall dHebron Univ Hosp, EAC BS Ctr Excellence, Metab & Bariatr Surg Unit, Barcelona, Spain
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Germans Trias & Pujol Res Inst, Campus Can Ruti,Carretera Can Ruti, Barcelona 08916, Spain
ISCIII, Biomed Res Ctr Red Fisiopatol Diabet & Enfermedad, Madrid, Spain
Jimenez-Pavon, D:
Univ Cadiz, Fac Educ Sci, MOVE IT Res Grp, Cadiz, Spain
Univ Cadiz, Fac Educ Sci, Dept Phys Educ, Cadiz, Spain
Univ Cadiz, Inst Res & Innovat Biomed Sci Prov Cadiz INiBICA, Cadiz, Spain
Lerin, C:
Inst Recerca St Joan Deu, Barcelona, Catalonia, Spain
Villarroya, F:
Univ Barcelona, Inst Biomed, Dept Biochem & Mol Biomed, Barcelona, Catalonia, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Barcelona, Catalonia, Spain
Inst Recerca St Joan Deu, Barcelona, Catalonia, Spain
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Germans Trias & Pujol Res Inst, Campus Can Ruti,Carretera Can Ruti, Barcelona 08916, Spain
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