Pomalidomide-dexamethasone for treatment of soft-tissue plasmacytomas in patients with relapsed/refractory multiple myeloma
Por:
Jimenez-Segura, R, Granell, M, Gironella, M, Abella, E, Garcia-Guinon, A, Oriol, A, Cabezudo, E, Clapes, V, Soler, JA, Escoda, L, Lopez-Pardo, J, de Larrea, CF, Cibeira, MT, Tovar, N, Isola, I, Blade, J and Rosinol, L
Publicada:
1 may 2019
Ahead of Print:
25 feb 2019
Resumen:
Objective The presence of plasmacytomas (Ps) in patients with multiple myeloma (MM) is associated with a poor outcome, both in patients treated conventionally and in patients treated with novel agents. Two types of plasmacytomas have being recognized: paraskeletal plasmacytomas (PPs) and extramedullary plasmacytomas (EMPs), being the incidence of EMPs lower but with worse prognosis. Our aim has been to analyze the efficacy of the pomalidomide-dexamethasone combination in this patient profile. Method In the present study, the efficacy of pomalidomide and dexamethasone in 21 patients from nine hospitals of Catalonia (Spain), with relapsed or refractory MM and Ps, was analyzed. For this purpose, we describe the evolution of paraprotein in serum and urine and the size of plasmacytomas during treatment with pomalidomide-dexamethasone. Results While 34% of the patients achieved a paraprotein response, only two patients with PPs (9%) responded (RC and PR). There were no responses among patients with EMPs. The median progression-free survival from the start of treatment with pomalidomide/dexamethasone was only 1.7 months and the median overall survival of 4.5 months. Conclusion In conclusion, pomalidomide and dexamethasone has limited efficacy in patients with advanced MM and soft-tissue plasmacytomas.
Filiaciones:
Jimenez-Segura, R:
Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Granell, M:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Gironella, M:
Hosp Univ Vall dHebron, Barcelona, Spain
Abella, E:
Hosp del Mar, Barcelona, Spain
Garcia-Guinon, A:
Hosp Arnau Vilanova, Lleida, Spain
:
Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
Cabezudo, E:
Hosp St Joan de Deu Manresa, Barcelona, Spain
Clapes, V:
Inst Catalan Oncol Hospitalet Llobregat, Barcelona, Spain
Soler, JA:
Hosp Parc Tauli Sabadell, Barcelona, Spain
Escoda, L:
Hosp Univ Joan XXIII, Tarragona, Spain
Lopez-Pardo, J:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
de Larrea, CF:
Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Cibeira, MT:
Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Tovar, N:
Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Isola, I:
Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Blade, J:
Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Rosinol, L:
Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
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