Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome
Por:
Peiro, OM, Farre, N, Cediel, G, Bonet, G, Rojas, S, Quintern, V and Bardaji, A
Publicada:
1 oct 2019
Ahead of Print:
27 sep 2019
Resumen:
Aim: To explore long-term prognostic value of SDF-1 in acute coronary syndrome (ACS). Materials & methods: We included 254 patients with ACS. Plasma SDF-1 was measured and patients were classified into tertiles of SDF-1. Results: Multivariate analysis showed third tertile of SDF-1 as an independent predictor of all-cause death (HR: 2.5; 95% CI: 1.2-5.2; p = 0.011) and the composite of major adverse cardiovascular and cerebrovascular events (HR: 1.8; 95% CI: 1.1-3.1; p = 0.031). SDF-1 added to a clinical model can improve all-cause death prediction (net reclassification improvement 0.362; 95% CI: 0.423-0.681; p = 0.027). Conclusion: SDF-1 is an independent predictor of all-cause mortality and major adverse cardiovascular and cerebrovascular events in long-term follow-up of patients with ACS and adds prognostic information beyond traditional cardiovascular risks factors.
Filiaciones:
Peiro, OM:
Joan XXIII Univ Hosp, Dept Cardiol, Tarragona, Spain
Rovira & Virgili Univ, Pere Virgili Hlth Res Inst, Tarragona, Spain
Farre, N:
Hosp Mar, Dept Cardiol, Heart Failure Unit, Barcelona, Spain
IMIM Hosp Mar Med Res Inst, Heart Dis Biomed Res Grp, Barcelona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
:
Hosp Badalona Germans Trias & Pujol, Heart Inst, Badalona, Spain
Bonet, G:
Joan XXIII Univ Hosp, Dept Cardiol, Tarragona, Spain
Rovira & Virgili Univ, Pere Virgili Hlth Res Inst, Tarragona, Spain
Rojas, S:
Joan XXIII Univ Hosp, Dept Cardiol, Tarragona, Spain
Rovira & Virgili Univ, Pere Virgili Hlth Res Inst, Tarragona, Spain
Quintern, V:
Joan XXIII Univ Hosp, Dept Cardiol, Tarragona, Spain
Rovira & Virgili Univ, Pere Virgili Hlth Res Inst, Tarragona, Spain
Bardaji, A:
Joan XXIII Univ Hosp, Dept Cardiol, Tarragona, Spain
Rovira & Virgili Univ, Pere Virgili Hlth Res Inst, Tarragona, Spain
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