Autoantibodies against type I IFNs in patients with life-threatening COVID-19


Por: Bastard, P, Rosen, LB, Zhang, Q, Michailidis, E, Hoffmann, HH, Zhang, Y, Dorgham, K, Philippot, Q, Rosain, J, Beziat, V, Manry, J, Shaw, E, Haljasmagi, L, Peterson, P, Lorenzo, L, Bizien, L, Trouillet-Assant, S, Dobbs, K, de Jesus, AA, Belot, A, Kallaste, A, Catherinot, E, Tandjaoui-Lambiotte, Y, Le Pen, J, Kerner, G, Bigio, B, Seeleuthner, Y, Yang, R, Bolze, A, Spaan, AN, Delmonte, OM, Abers, MS, Aiuti, A, Casari, G, Lampasona, V, Piemonti, L, Ciceri, F, Bilguvar, K, Lifton, RP, Vasse, M, Smadja, DM, Migaud, M, Hadjadj, J, Terrier, B, Duffy, D, Quintana-Murci, L, van de Beek, DV, Roussel, L, Vinh, DC, Tangye, SG, Haerynck, F, Dalmau, D, Martinez-Picado, J, Brodin, P, Nussenzweig, MC, Boisson-Dupuis, S, Rodriguez-Gallego, C, Vogt, G, Mogensen, TH, Oler, AJ, Gu, JW, Burbelo, PD, Cohen, JI, Biondi, A, Bettini, LR, D'Angio, M, Bonfanti, P, Rossignol, P, Mayaux, J, Rieux-Laucat, F, Husebye, ES, Fusco, F, Ursini, MV, Imberti, L, Sottini, A, Paghera, S, Quiros-Roldan, E, Rossi, C, Castagnoli, R, Montagna, D, Licari, A, Marseglia, GL, Duval, X, Ghosn, J, Tsang, JS, Goldbach-Mansky, R, Kisand, K, Lionakis, MS, Puel, A, Zhang, SY, Holland, SM, Gorochov, G, Jouangu, E, Rice, CM, Cobat, A, Notarangelo, LD, Abel, L, Su, HC and Casanova, JL
Publicada: 23 oct 2020 Ahead of Print: 24 sep 2020
Resumen:
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-omega (IFN-omega) (13 patients), against the 13 types of IFN-alpha (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for lifethreatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Filiaciones:
Bastard, P:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France

 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
Rosen, LB:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Zhang, Q:
 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
Michailidis, E:
 Rockefeller Univ, Lab Virol & Infect Dis, 1230 York Ave, New York, NY 10021 USA
Hoffmann, HH:
 Rockefeller Univ, Lab Virol & Infect Dis, 1230 York Ave, New York, NY 10021 USA
Zhang, Y:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Dorgham, K:
 Sorbonne Univ, INSERM, Ctr Immunol & Malad Infect CIMI Paris, Paris, France
Philippot, Q:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France
Rosain, J:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France
Beziat, V:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France

 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
Manry, J:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France
Shaw, E:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Haljasmagi, L:
 Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia
Peterson, P:
 Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia
Lorenzo, L:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France
Bizien, L:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France
Trouillet-Assant, S:
 Hosp Civils Lyon, Lyon Sud Hosp, Pierre Benite, France

 Lyon Univ, Int Ctr Res Infectiol, INSERM U1111, CNRS UMR 5308,ENS,UCBL, Lyon, France
Dobbs, K:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
de Jesus, AA:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Belot, A:
 Lyon Univ, Int Ctr Res Infectiol, INSERM U1111, CNRS UMR 5308,ENS,UCBL, Lyon, France

 Natl Referee Ctr Rheumat & AutoImmune & System Di, Lyon, France

 Hosp Civils Lyon, Lyon Immunopathol Federat LIFE, Lyon, France
Kallaste, A:
 Tartu Univ Hosp, Internal Med Clin, Tartu, Estonia
Catherinot, E:
 Foch Hosp, Dept Pneumol, Suresne, France
Tandjaoui-Lambiotte, Y:
 Avicenne Hosp, AP HP, INSERM U1272 Hypoxia & Lung, Bobigny, France
Le Pen, J:
 Rockefeller Univ, Lab Virol & Infect Dis, 1230 York Ave, New York, NY 10021 USA
Kerner, G:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France
Bigio, B:
 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
Seeleuthner, Y:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France
Yang, R:
 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
Bolze, A:
 Helix, San Mateo, CA USA
Spaan, AN:
 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA

 Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands
Delmonte, OM:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Abers, MS:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Aiuti, A:
 IRCCS San Raffaele Hosp, Milan, Italy

 Univ Vita Salute San Raffaele, Milan, Italy
Casari, G:
 IRCCS San Raffaele Hosp, Milan, Italy

 Univ Vita Salute San Raffaele, Milan, Italy
Lampasona, V:
 IRCCS San Raffaele Hosp, Milan, Italy

 Univ Vita Salute San Raffaele, Milan, Italy
Piemonti, L:
 IRCCS San Raffaele Hosp, Milan, Italy

 Univ Vita Salute San Raffaele, Milan, Italy
Ciceri, F:
 IRCCS San Raffaele Hosp, Milan, Italy

 Univ Vita Salute San Raffaele, Milan, Italy
Bilguvar, K:
 Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA
Lifton, RP:
 Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA

 Yale Univ, Sch Med, Yale Ctr Genome Anal, New Haven, CT USA

 Rockefeller Univ, Lab Human Genet & Genom, 1230 York Ave, New York, NY 10021 USA
Vasse, M:
 Hop Foch, Serv Biol Clin, Suresnes, France

 Hop Foch, UMR S 1176, Suresnes, France
Smadja, DM:
 Univ Paris, INSERM UMR S 1140, Biosurg Res Lab, Carpentier Fdn, Paris, France

 Hop Europeen Georges Pompidou, Paris, France
Migaud, M:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France
Hadjadj, J:
 Univ Paris, Imagine Inst, Lab Immunogenet Pediat Autoimmune Dis, INSERM UMR 1163, Paris, France
Terrier, B:
 Univ Paris, Dept Internal Med, Natl Referral Ctr Rare System Autoimmune Dis, AP HP,Ctr APHP CUP, Paris, France
Duffy, D:
 Inst Pasteur, Translat Immunol Lab, Paris, France
Quintana-Murci, L:
 Inst Pasteur, Human Evolutionary Genet Unit, CNRS UMR 2000, F-75015 Paris, France

 Coll France, Human Genom & Evolut, Paris, France
van de Beek, DV:
 Univ Amsterdam, Dept Neurol, Amsterdam UMC, Amsterdam Neurosci, Amsterdam, Netherlands
Roussel, L:
 McGill Univ, Ctr Hlth, Div Infect Dis, Dept Med, Montreal, PQ, Canada

 McGill Univ, Ctr Hlth, Infect Dis Susceptibil Program, Res Inst, Montreal, PQ, Canada
Vinh, DC:
 McGill Univ, Ctr Hlth, Div Infect Dis, Dept Med, Montreal, PQ, Canada

 McGill Univ, Ctr Hlth, Infect Dis Susceptibil Program, Res Inst, Montreal, PQ, Canada
Tangye, SG:
 Garvan Inst Med Res, Sydney, NSW 2010, Australia

 Univ New South Wales Sydney, Fac Med, St Vincents Clin Sch, Darlinghurst, NSW 2010, Australia
Haerynck, F:
 Ghent Univ Hosp, Dept Paediat Immunol & Pulmonol, Ctr Primary Immunodeficiency Ghent CPIG, PID Res Lab,Jeffrey Modell Diag & Res Ctr, Ghent, Belgium
Dalmau, D:
 Univ Barcelona, Infect Dis & HIV Serv, Fdn Docencia & Recerca Mutua Terrassa, Hosp Univ Mutua Terrassa, Barcelona, Catalonia, Spain
:
 irsiCaixa AIDS Res Inst, Badalona, Spain

 Inst Hlth Sci Res Germans Trias & Pujol IGTP, Badalona, Spain

 Univ Vic Central Univ Catalonia UVic UCC, Fac Med, Ctr Hlth & Social Care Res CESS, Infect Dis & Immun, Vic, Spain

 Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain
Brodin, P:
 Univ Vic Central Univ Catalonia UVic UCC, Fac Med, Ctr Hlth & Social Care Res CESS, Infect Dis & Immun, Vic, Spain

 Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Karolinska, Sweden

 Karolinska Univ Hosp, Dept Pediat Rheumatol, Karolinska, Sweden
Nussenzweig, MC:
 Rockefeller Univ, Lab Mol Immunol, 1230 York Ave, New York, NY 10021 USA

 Howard Hughes Med Inst, New York, NY 10065 USA
Boisson-Dupuis, S:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France

 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
Rodriguez-Gallego, C:
 Hosp Univ Gran Canaria Dr Negrin, Canarian Hlth Syst, Dept Immunol, Las Palmas Gran Canaria, Spain

 Univ Fernando Pessoa Canarias, Dept Clin Sci, Las Palmas Gran Canaria, Spain
Vogt, G:
 Univ Paris, Neglected Human Genet Lab, INSERM, Paris, France
Mogensen, TH:
 Aarhus Univ Hosp, Dept Infect Dis, Skejby, Denmark

 Aarhus Univ, Dept Biomed, Aarhus, Denmark
Oler, AJ:
 NIAID, Bioinformat & Computat Biosciences Branch, Off Cyber Infrastruct & Computat Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Gu, JW:
 NIAID, Bioinformat & Computat Biosciences Branch, Off Cyber Infrastruct & Computat Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Burbelo, PD:
 Natl Inst Dent Craniofacial Res NIDCR, Div Intramural Res, NIH, Bethesda, MD USA
Cohen, JI:
 NIAID, Lab Infect Dis, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Biondi, A:
 Univ Milano Bicocca, Pediat Dept, EuroBloodNet, MetabERN,Fdn MBBM Osped, Monza, Italy

 Univ Milano Bicocca, Ctr Tettamanti, European Reference Network PaedCan, EuroBloodNet,MetabERN,Fdn MBBM Osped, Monza, Italy
Bettini, LR:
 Univ Milano Bicocca, Pediat Dept, EuroBloodNet, MetabERN,Fdn MBBM Osped, Monza, Italy

 Univ Milano Bicocca, Ctr Tettamanti, European Reference Network PaedCan, EuroBloodNet,MetabERN,Fdn MBBM Osped, Monza, Italy
D'Angio, M:
 Univ Milano Bicocca, Pediat Dept, EuroBloodNet, MetabERN,Fdn MBBM Osped, Monza, Italy

 Univ Milano Bicocca, Ctr Tettamanti, European Reference Network PaedCan, EuroBloodNet,MetabERN,Fdn MBBM Osped, Monza, Italy
Bonfanti, P:
 Univ Milano Bicocca, San Gerardo Hosp, Dept Infect Dis, Monza, Italy
Rossignol, P:
 Univ Lorraine, Plurithemat Clin Invest Ctr INSERM CIC P 1433, F CRIN INICRCT Cardiovasc & Renal Clin Trialis, INSERM U1116,CHRU Nancy Hopitaux Brabois, Nancy, France
Mayaux, J:
 Univ Paris, Pitie Salpetriere Hosp, AP HP, Intens Care Unit, Paris, France
Rieux-Laucat, F:
 Univ Paris, Imagine Inst, Lab Immunogenet Pediat Autoimmune Dis, INSERM UMR 1163, Paris, France
Husebye, ES:
 Univ Bergen, Dept Clin Sci, Bergen, Norway

 Univ Bergen, KG Jebsen Ctr Autoimmune Disorders, Bergen, Norway

 Haukeland Hosp, Dept Med, Bergen, Norway

 Karolinska Inst, Dept Med Solna, Stockholm, Sweden
Fusco, F:
 A Buzzati Traverso Consiglio Nazl Ric, Inst Genet & Biophys, Human Mol Genet Lab, Naples, Italy
Ursini, MV:
 A Buzzati Traverso Consiglio Nazl Ric, Inst Genet & Biophys, Human Mol Genet Lab, Naples, Italy
Imberti, L:
 ASST Spedali Civili Brescia, Ctr Ric Ematooncol AIL CREA Lab, Diagnost Dept, Brescia, Italy
Sottini, A:
 ASST Spedali Civili Brescia, Ctr Ric Ematooncol AIL CREA Lab, Diagnost Dept, Brescia, Italy
Paghera, S:
 ASST Spedali Civili Brescia, Ctr Ric Ematooncol AIL CREA Lab, Diagnost Dept, Brescia, Italy
Quiros-Roldan, E:
 Univ Brescia, Dept Infect & Trop Dis, Brescia, Italy

 ASST Spedali Brescia, Brescia, Italy
Rossi, C:
 ASST Spedali Civili Brescia, Direz Sanit, Brescia, Italy
Castagnoli, R:
 Univ Pavia, Fdn IRCCS Policlin San Matteo, Dept Pediat, Pavia, Italy
Montagna, D:
 Fdn IRCCS Policlin San Matteo, Lab Immunol & Transplantat, Pavia, Italy

 Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pavia, Italy
Licari, A:
 Univ Pavia, Fdn IRCCS Policlin San Matteo, Dept Pediat, Pavia, Italy
Marseglia, GL:
 Univ Pavia, Fdn IRCCS Policlin San Matteo, Dept Pediat, Pavia, Italy
Duval, X:
 INSERM CIC 1425, Paris, France

 Univ Hosp Bichat, AP HP, Paris, France

 Univ Paris Diderot Paris 7, UFR Med Bichat, Paris, France

 Univ Paris, UMRS1137, INSERM, Infect Antimicrobials Modelling Evolut IAME, Paris, France

 Bichat Claude Bernard Hosp, AP HP, Infect & Trop Dis Dept, Paris, France
Ghosn, J:
 Univ Paris, UMRS1137, INSERM, Infect Antimicrobials Modelling Evolut IAME, Paris, France

 Bichat Claude Bernard Hosp, AP HP, Infect & Trop Dis Dept, Paris, France
Tsang, JS:
 NIH, Ctr Human Immunol, Bldg 10, Bethesda, MD 20892 USA

 NIAID, Multiscale Syst Biol Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Goldbach-Mansky, R:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Kisand, K:
 Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia
Lionakis, MS:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Puel, A:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France

 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
Zhang, SY:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France

 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
Holland, SM:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Gorochov, G:
 Sorbonne Univ, INSERM, Ctr Immunol & Malad Infect CIMI Paris, Paris, France

 Hop La Pitie Salpetriere, AP HP, Dept Immunol, Paris, France
Jouangu, E:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France

 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
Rice, CM:
 Rockefeller Univ, Lab Virol & Infect Dis, 1230 York Ave, New York, NY 10021 USA
Cobat, A:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France

 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
Notarangelo, LD:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Abel, L:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France

 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA
Su, HC:
 NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Casanova, JL:
 Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

 Univ Paris, Imagine Inst, Paris, France

 Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA

 Howard Hughes Med Inst, New York, NY 10065 USA

 Necker Hosp Sick Children, AP HP, Pediat Hematol & Immunol Unit, Paris, France
ISSN: 00368075





Science
Editorial
American Association for the Advancement of Science, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 370 Número: 6515
Páginas: 423-423
WOS Id: 000581077200035
ID de PubMed: 32972996
imagen Green Published, Green Accepted, Green Submitted

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