Quality of life during one year of postoperative prophylactic drug therapy after intestinal resection in Crohn's patients: Results of the APPRECIA trial
Por:
Taxonera, C, Lopez-Sanroman, A, Vera-Mendoza, I, Domenech, E, Ruiz, VV, Marin-Jimenez, I, Guardiola, J, Castro, L, Esteve, M, Iglesias, E, Ceballos, D, Martinez-Montiel, P, Gisbert, JP, Minguez, M, Echarri, A, Calvet, X, Barrio, J, Hinojosa, J, Martin-Arranz, MD, Marquez-Mosquera, L, Bermejo, F, Rimola, J, Alba, C, Pons, V and Nos, P
Publicada:
1 abr 2019
Ahead of Print:
14 ene 2019
Resumen:
Background: In APPRECIA trial, Crohn's disease (CD) patients undergoing intestinal resection were randomized to postoperative adalimumab (ADA) or azathioprine (AZA).
Aims: To evaluate health-related quality of life (HRQoL) in APPRECIA trial.
Methods: HRQoL was evaluated using disease-specific shortened Spanish version of the IBDQ (SIBDQ-9) and generic European Quality of Life-5 Dimensions (EQ-5D) questionnaires, completed at baseline and at weeks 24 and 52.
Results: Sixty-one patients (37 ADA and 24 AZA) had evaluable data for HRQoL. Patients treated with ADA or AZA had significant improvement from baseline to weeks 24 and 52 in SIBDQ-9 and EQ-5D (p < 0.001 and p = 0.006 for all comparisons, respectively). There were no differences between treatment arms in mean change in SIBDQ-9 and EQ-5D at weeks 24 and 52 vs baseline. Only patients without endoscopic recurrence had significant improvement in SIBDQ-9 (p < 0.001) and EQ-5D (p < 0.001) at week 52.
At week 52, there was a high to moderate negative correlation between CDAI score with SIBDQ-9 score( Pearson's r: -0.768) and with EQ-5D index (r: -0.644).
Conclusion: HRQoL improved after intestinal resection in CD, irrespective of the postoperative therapyused (ADA or AZA). Outcomes in HRQoL were associated with prevention of endoscopic recurrence, sinceimprovements in HRQoL were only significant in patients with endoscopic remission at 1 year. (c) 2019 Editrice Gastroenterologica Italiana S. r. l. Published by Elsevier Ltd. All rights reserved.
Filiaciones:
Taxonera, C:
San Carlos Clin Hosp, San Carlos Hlth Res Inst IdISSC, IBD Unit, Madrid, Spain
Lopez-Sanroman, A:
Ramon Y Cajal Univ Hosp, Gastroenterol Hepatol Unit, Madrid, Spain
Vera-Mendoza, I:
Puerta de Hierro Univ Hosp, Gastroenterol Hepatol Unit, Majadahonda, Spain
:
Germans Trias & Pujol Hosp, Gastroenterol Hepatol Unit, Badalona, Spain
Carlos III Hlth Inst, Ctr Biomed Res Liver & Digest Dis Network CIBEReh, Madrid, Spain
Ruiz, VV:
Puerto Real Univ Hosp, Gen Surg Unit, Puerto Real, Spain
Marin-Jimenez, I:
Gregorio Marannon Univ Hosp, Gregorio Marannon Hlth Res Inst IiSGM, Digest Dis Unit, Madrid, Spain
Guardiola, J:
Univ Hosp Bellvitge IDIBELL, Gastroenterol Hepatol Unit, Barcelona, Spain
Castro, L:
Virgen de Macarena Univ Hosp, Digest Dis Unit, Seville, Spain
Esteve, M:
Carlos III Hlth Inst, Ctr Biomed Res Liver & Digest Dis Network CIBEReh, Madrid, Spain
Mutua Terrassa Univ Hosp, Gastroenterol Hepatol Unit, Terrassa, Spain
Iglesias, E:
Reina Sofia Hosp, Digest Dis Unit, Cordoba, Spain
Ceballos, D:
Univ Hosp Gran Canaria Doctor Negrin, Gastroenterol Hepatol Unit, Las Palmas Gran Canaria, Spain
Martinez-Montiel, P:
Univ Hosp October 12, Digest Dis Unit, Madrid, Spain
Gisbert, JP:
Carlos III Hlth Inst, Ctr Biomed Res Liver & Digest Dis Network CIBEReh, Madrid, Spain
Univ Hosp La Princesa, Inst Invest Sanitaria La Princesa IIS IP, Digest Dis Unit, Madrid, Spain
Minguez, M:
Univ Valencia, Clin Hosp Valencia, Digest Dis Unit, Valencia, Spain
Echarri, A:
Arquitecto Marcide Hosp, Digest Dis Unit, Ferrol, Spain
Calvet, X:
Carlos III Hlth Inst, Ctr Biomed Res Liver & Digest Dis Network CIBEReh, Madrid, Spain
Healthcare Corp Parc Tauli, Digest Dis Unit, Sabadell, Spain
Barrio, J:
Rio Hortega Univ Hosp, Digest Dis Unit, Valladolid, Spain
Hinojosa, J:
Hosp Manises, Digest Dis Unit, Valencia, Spain
Martin-Arranz, MD:
La Paz Univ Hosp, Digest Dis Unit, Madrid, Spain
Marquez-Mosquera, L:
Mar Hosp, Gastroenterol Hepatol Unit, Barcelona, Spain
Bermejo, F:
Univ Hosp Fuenlabrada, Digest Dis Unit, Fuenlabrada, Spain
Rimola, J:
Univ Barcelona, Clin Hosp, Radiol Unit, Barcelona, Spain
Alba, C:
San Carlos Clin Hosp, San Carlos Hlth Res Inst IdISSC, IBD Unit, Madrid, Spain
Pons, V:
Carlos III Hlth Inst, Ctr Biomed Res Liver & Digest Dis Network CIBEReh, Madrid, Spain
Univ La Fe, Digest Dis Unit, Valencia, Spain
Polytech Hosp La Fe, Digest Dis Unit, Valencia, Spain
Nos, P:
Carlos III Hlth Inst, Ctr Biomed Res Liver & Digest Dis Network CIBEReh, Madrid, Spain
Univ La Fe, Digest Dis Unit, Valencia, Spain
Polytech Hosp La Fe, Digest Dis Unit, Valencia, Spain
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