Cytokeratin expression in plasmablastic lymphoma - a possible diagnostic pitfall in the routine work-up of tumours
Por:
Huettl, KS, Staiger, AM, Horn, H, Frontzek, F, Goodlad, JR, Tapia, G, Rosenwald, A, Klapper, W, Fend, F, Climent, F, Castellvi, J, Tzankov, A, Dirnhofer, S, Baptista, MJ, Navarro, JT, Anagnostopoulos, I, Hartmann, W, Lenz, G and Ott, G
Publicada:
1 may 2021
Ahead of Print:
1 dic 2020
Resumen:
Aims Plasmablastic lymphoma (PBL) is a rare aggressive B-cell lymphoma that frequently arises at extranodal sites in the setting of immunosuppression. The diagnosis of PBL is complex, owing to a frequent solid or cohesive growth pattern, and an often unusual immunophenotype. Several case reports have described cytokeratin (CK) expression in PBL, introducing a diagnostic pitfall. The aim of this study was to determine the frequency of CK expression in PBL in the largest series available to date.
Methods and results By using immunohistochemistry in a cohort of 72 PBLs, we identified CK8/18 positivity in 11 of 72 cases (15%) and AE1/3 positivity in six of 65 cases (9%), clearly contrasting with a control series of non-PBL aggressive B-cell lymphomas (one of 96 diffuse large B-cell lymphomas), as well as with data in the literature describing only occasional CK expression in haematological neoplasms.
Conclusions Our data indicate CK expression in a substantial number (15%) of PBLs. In view of the particular morphological features of PBL and its frequent negativity for the common leukocyte antigen and B-cell markers, this feature represents a pitfall in the routine diagnostic work-up of PBL, and requires more extensive immunohistochemical and molecular characterisation of cases entering the differential diagnosis.
Filiaciones:
Huettl, KS:
Robert Bosch Krankenhaus, Dept Clin Pathol, Auerbachstr 110, D-70376 Stuttgart, Germany
Staiger, AM:
Robert Bosch Krankenhaus, Dept Clin Pathol, Auerbachstr 110, D-70376 Stuttgart, Germany
Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany
Univ Tubingen, Tubingen, Germany
Horn, H:
Robert Bosch Krankenhaus, Dept Clin Pathol, Auerbachstr 110, D-70376 Stuttgart, Germany
Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany
Univ Tubingen, Tubingen, Germany
Frontzek, F:
Univ Munster, Med Dept A, Oncol & Pneumol, Haematol, Munster, Germany
Goodlad, JR:
Queen Elizabeth Univ Hosp, Dept Pathol, Glasgow, Lanark, Scotland
:
Hosp Badalona Germans Trias & Pujol, Pathol Dept, Badalona, Spain
Rosenwald, A:
Univ Wurzburg, Inst Pathol, Wurzburg, Germany
Comprehens Canc Ctr Mainfranken CCCMF, Wurzburg, Germany
Klapper, W:
Univ Klinikum Schleswig Holstein, Inst Pathol, Haematopathol Sect, Kiel, Germany
Univ Klinikum Schleswig Holstein, Lymph Node Registry, Kiel, Germany
Fend, F:
Eberhard Karls Univ Tubingen, Univ Hosp Tubingen, Inst Pathol & Neuropathol, Tubingen, Germany
Eberhard Karls Univ Tubingen, Univ Hosp Tubingen, Comprehens Canc Ctr Tubingen, Tubingen, Germany
Climent, F:
Hosp Univ Bellvitge IDIBELL, Dept Pathol, Lhospitalet De Llobregat, Barcelona, Spain
Castellvi, J:
Hosp Valle De Hebron, Dept Pathol, Barcelona, Spain
Tzankov, A:
Univ Basel, Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland
Dirnhofer, S:
Univ Basel, Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland
:
Josep Carreras Leukaemia Res Inst, Badalona, Spain
:
Josep Carreras Leukaemia Res Inst, Dept Haematol, ICO Germans Trias & Pujol, Badalona, Spain
Anagnostopoulos, I:
Charite Univ Med Berlin, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Berlin Inst Hlth, Berlin, Germany
Dept Hematol Oncol & Tumor Immunol, Virchow Campus, Berlin, Germany
Mol Krebsforschungszentrum, Berlin, Germany
Hartmann, W:
Univ Hosp Muenster, Gerhard Domagk Inst Pathol, Div Translat Pathol, Munster, Germany
Lenz, G:
Univ Munster, Med Dept A, Oncol & Pneumol, Haematol, Munster, Germany
Ott, G:
Robert Bosch Krankenhaus, Dept Clin Pathol, Auerbachstr 110, D-70376 Stuttgart, Germany
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