ESSDAI activity index of the SJoGRENSER cohort: analysis and comparison with other European cohorts
Por:
Rosas, J, Sanchez-Piedra, C, Fernandez-Castro, M, Andreu, JL, Martinez-Taboada, V, Olive, A, Menor, R, Rodriguez, B, Aparicio, AG, Longo, FJL, Manrique-Arija, S, Vadillo, JAG, Barato, SG, Lopez-Gonzalez, R, Narvaez, FJ, Galisteo, C, Martin, JG, Lucea, ER, Naranjo, A, Erausquin, C, Rua-Figueroa, I, Illera, O, Romani, L, Melchor, S, Moreira, B, Raya, E, Lopez, MR, Mourino, C, Pego, JM, Cid, N, Judez, E, Moriano, C, Torrente, V, Corominas, H, Magallon, BG, Astete, CG, Castellvi, I, Bohorquez, C, Loricera, J, Belzunegui, J and Cobo, T
Publicada:
1 jun 2019
Ahead of Print:
19 mar 2019
Resumen:
The objective of the study was to assess the ESSDAI index characteristics in the SJoGRENSER cohort (Spanish Rheumatology Association's registry of patients with Primary Sjogren Syndrome [PSS]). SJoGRENSER is a prospective multicentric study on a cohort of Spanish patients with PSS who meet the 2002 American-European consensus from rheumatology units. 298 variables were studied in patients for the inclusion of the study from an anonymous list from each department. The ESSDAI (EULAR Sjogren's syndrome disease activity index) includes 12 domains and measures systematic activity in PSS patients. Each domain is divided into 3-4 levels, (0: no activity; 1: low activity; 2: moderate activity; 3: high activity) and is attributed a weight. Each domain score is obtained by multiplying the activity level by the weight assigned. According to ESSDAI: low activity<5; moderate activity 5-13, and high activity14. ESSDAI was compared between several European PSS cohorts (EULAR, ASSES, GEAS, GRISS, Ducth). 437 patients were included from 33 Spanish rheumatology units. 95.2% were women with a median age of 58.63years [p25-p75: 50.02-67.98 years] and average PSS evolution of 10.4years (6-16years). ESSDAI median on entering the study was 2 (0-4). 31% of patients had ESSDAI 0; low activity 49%, moderate activity 15%, and high activity 5%. Those with greater activity were the joint, haematological and biological domains, whereas the lung was the most affected organ with pleural and parenchymatous involvement. Unlike other European cohorts, the initial SJoGRENSER cohort was characterised by low-zero systemic activity in 80% of patients, which differentiates it from other cohorts and provides a prospective study opportunity.
Filiaciones:
Rosas, J:
Hosp Marina Baixa, Dept Rheumatol, Alicante, Spain
Sanchez-Piedra, C:
Spanish Soc Rheumatol, Res Unit, Madrid, Spain
Fernandez-Castro, M:
Hosp Univ Puerta de Hierro Majadahonda, Dept Rheumatol, Madrid, Spain
Andreu, JL:
Hosp Univ Puerta de Hierro Majadahonda, Dept Rheumatol, Madrid, Spain
Martinez-Taboada, V:
Hosp Marques de Valdecilla, Dept Rheumatol, Santander, Spain
Univ Cantabria, Fac Med, Santander, Spain
:
Hosp Badalona Germans Trias & Pujol, Dept Rheumatol, Barcelona, Spain
Menor, R:
Hosp Gen Jerez de la Frontera, Jerez de la Frontera, Spain
Rodriguez, B:
Hosp Univ Canarias, Santa Cruz De Tenerife, Spain
Aparicio, AG:
Hosp Virgen Salud, Toledo, Spain
Longo, FJL:
Hosp Gregorio Maranon, Madrid, Spain
Manrique-Arija, S:
Hosp Carlos Haya, Malaga, Spain
Vadillo, JAG:
Hosp La Princesa, Madrid, Spain
Barato, SG:
Hosp Gen Alicante, Alicante, Spain
Lopez-Gonzalez, R:
Hosp Virgen de la Concha, Zamora, Spain
Narvaez, FJ:
Hosp Bellvitge Princeps Espanya, Barcelona, Spain
Galisteo, C:
Hosp Parc Tauli, Sabadell, Spain
Martin, JG:
Hosp Madrid Norte Sanchinarro, Madrid, Spain
Lucea, ER:
Hosp Basurto, Basurto, Spain
Naranjo, A:
Hosp Doctor Negrin, Las Palmas Gran Canaria, Spain
Erausquin, C:
Hosp Doctor Negrin, Las Palmas Gran Canaria, Spain
Rua-Figueroa, I:
Hosp Doctor Negrin, Las Palmas Gran Canaria, Spain
Illera, O:
Hosp Infanta Sofia, Madrid, Spain
Romani, L:
Hosp Virgen de las Nieves, Granada, Spain
Melchor, S:
Hosp Doce Octubre, Madrid, Spain
Moreira, B:
Hosp Sierrallana, Torrelavega, Spain
Raya, E:
Hosp Clin San Cecilio, Granada, Spain
Lopez, MR:
Hosp Meixoeiro, Vigo, Spain
Mourino, C:
Hosp Meixoeiro, Vigo, Spain
Pego, JM:
Hosp Meixoeiro, Vigo, Spain
Cid, N:
Hosp Valme, Seville, Spain
Judez, E:
Hosp Albacete, Albacete, Spain
Moriano, C:
Hosp Leon, Leon, Spain
Torrente, V:
Hosp LHospitalet, Lhospitalet De Llobregat, Spain
Corominas, H:
Hosp St Joan Despi Moises Broggi, Barcelona, Spain
Magallon, BG:
Hosp Miguel Servet, Zaragoza, Spain
Astete, CG:
Hosp Ramon & Cajal, Madrid, Spain
Castellvi, I:
Hosp San Pau & Santa Creu, Barcelona, Spain
Bohorquez, C:
Hosp Principe Asturias, Alcala De Henares, Spain
Loricera, J:
Hosp Marques de Valdecilla, Santander, Spain
Belzunegui, J:
Hosp Donostia, Gipuzkoa, Spain
Cobo, T:
Hosp Infanta Sofia, Madrid, Spain
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