Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients
Por:
Garcia-Marchena, N, Pizarro, N, Pavon, FJ, Martinez-Huelamo, M, Flores-Lopez, M, Requena-Ocana, N, Araos, P, Silva-Pena, D, Suarez, J, Santin, LJ, de la Torre, R, de Fonseca, FR and Serrano, A
Publicada:
13 oct 2020
Ahead of Print:
13 oct 2020
Resumen:
Lysophosphatidic acid (LPA) species are bioactive lipids participating in neurodevelopmental processes. The aim was to investigate whether the relevant species of LPA were associated with clinical features of alcohol addiction. A total of 55 abstinent alcohol use disorder (AUD) patients were compared with 34 age/sex/body mass index-matched controls. Concentrations of total LPA and 16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA species were quantified and correlated with neuroplasticity-associated growth factors including brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-2, and neurotrophin-3 (NT-3). AUD patients showed dysexecutive syndrome (22.4%) and memory impairment (32.6%). Total LPA, 16:0-LPA, 18:0-LPA and 18:1-LPA concentrations, were decreased in the AUD group compared to control group. Total LPA, 16:0-LPA, 18:2-LPA and 20:4-LPA concentrations were decreased in men compared to women. Frontal lobe functions correlated with plasma LPA species. Alcohol-cognitive impairments could be related with the deregulation of the LPA species, especially in 16:0-LPA, 18:1-LPA and 20:4-LPA. Concentrations of BDNF correlated with total LPA, 18:2-LPA and 20:4-LPA species. The relation between LPA species and BDNF is interesting in plasticity and neurogenesis functions, their involvement in AUD might serve as a biomarker of cognitive impairment.
Filiaciones:
:
Hosp Reg Univ Malaga, Lab Med Regenerat, Unidad Gest Clin Salud Mental, Inst Invest Biomed Malaga IBIMA, Avda Carlos Haya 82, Malaga 29010, Spain
Invest Ciencies Salut Germans Trias & Pujol IGTP, Inst D, Unidad Adicc Serv Med Interna, Campus Can Ruti,Carrer Canyet S-N, Badalona 08916, Spain
Pizarro, N:
Inst Hosp Mar Invest Med IMIM, Integrat Pharmacol & Syst Neurosci Res Grp, Programa Invest Neurociencias, Dr Aiguader 88, Barcelona 08003, Spain
Pavon, FJ:
Hosp Reg Univ Malaga, Lab Med Regenerat, Unidad Gest Clin Salud Mental, Inst Invest Biomed Malaga IBIMA, Avda Carlos Haya 82, Malaga 29010, Spain
Hosp Univ Virgen de la Victoria Malaga, Unidad Gest Clin Corazon, Inst Invest Biomed Malaga IBIMA, Malaga, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Martinez-Huelamo, M:
Inst Hosp Mar Invest Med IMIM, Integrat Pharmacol & Syst Neurosci Res Grp, Programa Invest Neurociencias, Dr Aiguader 88, Barcelona 08003, Spain
Univ Barcelona, Dept Nutr Ciencias Alimentos & Gastron, Fac Farm & Ciencias Alimentos, Barcelona, Spain
Flores-Lopez, M:
Hosp Reg Univ Malaga, Lab Med Regenerat, Unidad Gest Clin Salud Mental, Inst Invest Biomed Malaga IBIMA, Avda Carlos Haya 82, Malaga 29010, Spain
Requena-Ocana, N:
Hosp Reg Univ Malaga, Lab Med Regenerat, Unidad Gest Clin Salud Mental, Inst Invest Biomed Malaga IBIMA, Avda Carlos Haya 82, Malaga 29010, Spain
Araos, P:
Hosp Reg Univ Malaga, Lab Med Regenerat, Unidad Gest Clin Salud Mental, Inst Invest Biomed Malaga IBIMA, Avda Carlos Haya 82, Malaga 29010, Spain
Univ Malaga UMA, Dept Psicobiol & Metodol Ciencias Comportamiento, Inst Invest Biomed Malaga IBIMA, Fac Psicol, Malaga, Spain
Silva-Pena, D:
Hosp Reg Univ Malaga, Lab Med Regenerat, Unidad Gest Clin Salud Mental, Inst Invest Biomed Malaga IBIMA, Avda Carlos Haya 82, Malaga 29010, Spain
Suarez, J:
Hosp Reg Univ Malaga, Lab Med Regenerat, Unidad Gest Clin Salud Mental, Inst Invest Biomed Malaga IBIMA, Avda Carlos Haya 82, Malaga 29010, Spain
Santin, LJ:
Univ Malaga UMA, Dept Psicobiol & Metodol Ciencias Comportamiento, Inst Invest Biomed Malaga IBIMA, Fac Psicol, Malaga, Spain
de la Torre, R:
Inst Hosp Mar Invest Med IMIM, Integrat Pharmacol & Syst Neurosci Res Grp, Programa Invest Neurociencias, Dr Aiguader 88, Barcelona 08003, Spain
de Fonseca, FR:
Hosp Reg Univ Malaga, Lab Med Regenerat, Unidad Gest Clin Salud Mental, Inst Invest Biomed Malaga IBIMA, Avda Carlos Haya 82, Malaga 29010, Spain
Serrano, A:
Hosp Reg Univ Malaga, Lab Med Regenerat, Unidad Gest Clin Salud Mental, Inst Invest Biomed Malaga IBIMA, Avda Carlos Haya 82, Malaga 29010, Spain
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