International prevalence and risk factors evaluation for drug-resistant Streptococcus pneumoniae pneumonia


Por: Aliberti, S, Cook, GS, Babu, BL, Reyes, LF, Rodriguez, AH, Sanz, F, Soni, NJ, Anzueto, A, Faverio, P, Sadud, RF, Muhammad, I, Prat, C, Vendrell, E, Neves, J, Kaimakamis, E, Feneley, A, Swarnakar, R, Franzetti, F, Carugati, M, Morosi, M, Monge, E, Restrepo, MI, Aruj, PK, Attorri, S, Barimboim, E, Caeiro, JP, Garzon, MI, Cambursano, VH, Ceccato, A, Chertcoff, J, Lascar, F, Di Tulio, F, Diaz, AC, de Vedia, L, Ganaha, MC, Lambert, S, Lopardo, G, Lopez, V, Luna, CM, Malberti, AG, Morcillo, N, Tartara, S, Pensotti, C, Pereyra, B, Scapellato, PG, Stagnaro, JP, Shah, S, Lotsch, F, Thalhammer, F, Anseeuw, K, Francois, CA, Van Braeckel, E, Vincent, JL, Djimon, MZ, Bashi, J, Dodo, R, Nouer, SA, Chipev, P, Encheva, M, Miteva, D, Petkova, D, Balkissou, AD, Yone, EWP, Ngahane, BHM, Shen, N, Xu, JF, Rico, CAB, Buitrago, R, Paternina, FJP, Ntumba, JMK, Carevic, VV, Jakopovic, M, Jankovic, M, Matkovic, Z, Mitrecic, I, Jacobsson, MLB, Christensen, AB, Bodtger, UCH, Meyer, CN, Jensen, AV, Baunbaek-knudsen, G, Petersen, PT, Andersen, S, Abd El-Wahhab, IES, Morsy, NE, Shafiek, H, Sobh, E, Abdulsemed, KA, Bertrand, F, Brun-Buisson, C, de Montmollin, E, Fartoukh, M, Messika, J, Tattevin, P, Khoury, A, Ebruke, B, Dreher, M, Kolditz, M, Meisinger, M, Pletz, MW, Hagel, S, Rupp, J, Schaberg, T, Spielmanns, M, Creutz, P, Suttorp, N, Siaw-Lartey, B, Dimakou, K, Papapetrou, D, Tsigou, E, Ampazis, D, Bhatia, M, Dhar, R, D'Souza, G, Garg, R, Koul, PA, Mahesh, PA, Jayaraj, BS, Narayan, KV, Udnur, HB, Krishnamurthy, SB, Kant, S, Limaye, S, Salvi, S, Golshani, K, Keatings, VM, Martin-Loeches, I, Maor, Y, Strahilevitz, J, Battaglia, S, Carrabba, M, Ceriana, P, Confalonieri, M, Monforte, AD, Del Prato, B, De Rosa, M, Fantini, R, Fiorentino, G, Gammino, MA, Menzella, F, Milani, G, Nava, S, Palmiero, G, Petrino, R, Gabrielli, B, Rossi, P, Sorino, C, Steinhilber, G, Zanforlin, A, Carone, M, Patella, V, Scarlata, S, Comel, A, Kurahashi, K, Bacha, ZA, Ugalde, DB, Zuniga, OC, Villegas, JF, Medenica, M, van de Garde, EMW, Mihsra, DR, Shrestha, P, Ridgeon, E, Awokola, BI, Nwankwo, ONO, Olufunlola, AB, Olumide, S, Ukwaja, KN, Irfan, M, Minarowski, L, Szymon, S, Froes, F, Leuschner, P, Meireles, M, Ferrao, C, Ravara, SB, Brocovschii, V, Ion, C, Rusu, D, Toma, C, Chirita, D, Dorobat, CM, Birkun, A, Kaluzhenina, A, Almotairi, A, Bukhary, ZAA, Edathodu, J, Fathy, A, Enani, AMA, Mohamed, NE, Memon, JU, Bella, A, Bogdanovic, N, Milenkovic, B, Pesut, D, Borderias, L, Garcia, NMB, Alarcon, HC, Cilloniz, C, Torres, A, Diaz-Brito, V, Casas, X, Gonzalez, AE, Fernandez-Almira, ML, Gallego, M, Gaspar-Garcia, I, del Castillo, JG, Victoria, PJ, Martinez, EL, de Molina, RM, Marcos, PJ, Menendez, R, Pando-Sandoval, A, Aymerich, CP, de la Torre, AL, Garcia-Olive, I, Rello, J, Moyano, S, Sibila, O, Rodrigo-Troyano, A, Sole-Violan, J, Uranga, A, van Boven, JFM, Torra, EV, Pujol, JA, Feldman, C, Yum, HK, Fiogbe, AA, Yangui, F, Bilaceroglu, S, Dalar, L, Yilmaz, U, Bogomolov, A, Elahi, N, Dhasmana, DJ, Ions, R, Skeemer, J, Woltmann, G, Hancock, C, Hill, AT, Rudran, B, Ruiz-Buitrago, S, Campbell, M, Whitaker, P, Youzguin, A, Singanayagam, A, Allen, KS, Brito, V, Dietz, J, Dysart, CE, Kellie, SM, Franco-Sadud, RA, Meier, G, Gaga, M, Holland, TL, Bergin, SP, Kheir, F, Landmeier, M, Lois, M, Nair, GB, Patel, H, Reyes, K, Rodriguez-Cintron, W, Saito, S, Noda, J, Hinojosa, CI, Levine, SM, Angel, LF, Whitlow, KS, Hipskind, J, Sukhija, K, Totten, V, Wunderink, RG, Shah, RD, Mateyo, KJ, Noriega, L, Alvarado, E, Aman, M and Labra, L

Publicada: 1 oct 2019 Ahead of Print: 9 jul 2019
Resumen:
Objective: Streptococcus pneumoniae is the most frequent bacterial pathogen isolated in subjects with Community-acquired pneumonia (CAP) worldwide. Limited data are available regarding the current global burden and risk factors associated with drug-resistant Streptococcus pneumoniae (DRSP) in CAP subjects. We assessed the multinational prevalence and risk factors for DRSP-CAP in a multinational point-prevalence study. Design: The prevalence of DRSP-CAP was assessed by identification of DRSP in blood or respiratory samples among adults hospitalized with CAP in 54 countries. Prevalence and risk factors were compared among subjects that had microbiological testing and antibiotic susceptibility data. Multivariate logistic regressions were used to identify risk factors independently associated with DRSP-CAP. Results: 3,193 subjects were included in the study. The global prevalence of DRSP-CAP was 1.3% and continental prevalence rates were 7.0% in Africa, 1.2% in Asia, and 1.0% in South America, Europe, and North America, respectively. Macrolide resistance was most frequently identified in subjects with DRSP-CAP (0.6%) followed by penicillin resistance (0.5%). Subjects in Africa were more likely to have DRSP-CAP (OR: 7.6; 95% CI: 3.34-15.35, p < 0.001) when compared to centres representing other continents. Conclusions: This multinational point-prevalence study found a low global prevalence of DRSP-CAP that may impact guideline development and antimicrobial policies. Published by Elsevier Ltd on behalf of The British Infection Association.

Filiaciones:
Aliberti, S:
 Fdn IRCCS Ca Granda Osped Maggiore Policlin, Resp Unit, Milan, Italy

 Cyst Fibrosis Adult Ctr, Milan, Italy

 Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy

Cook, GS:
 Univ Texas Hlth Sci Ctr San Antonio, Div Pulm Dis & Crit Care Med, San Antonio, TX 78229 USA

Babu, BL:
 Univ Texas Hlth Sci Ctr San Antonio, Div Pulm Dis & Crit Care Med, San Antonio, TX 78229 USA

 South Texas Vet Hlth Care Syst, Div Pulm Dis & Crit Care Med, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA

Reyes, LF:
 Univ Sabana, Dept Microbiol, Bogota, Colombia

Rodriguez, AH:
 Rovira & Virgili Univ, Hosp Univ Joan XXIII, Crit Care Med, Tarragona, Spain

 CIBERes Biomed Res Network Resp Dis, Tarragona, Spain

Sanz, F:
 Consorci Hosp Gen Univ Valencia, Pulmonol Dept, Valencia, Spain

 Consorci Hosp Gen Univ Valencia, Serv Neumol, Valencia, Spain

Soni, NJ:
 Univ Texas Hlth Sci Ctr San Antonio, Div Pulm Dis & Crit Care Med, San Antonio, TX 78229 USA

 South Texas Vet Hlth Care Syst, Div Pulm Dis & Crit Care Med, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA

 Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Div Hosp Med, San Antonio, TX 78229 USA

 Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Div Pulm Crit Care Med, San Antonio, TX 78229 USA

Anzueto, A:
 Univ Texas Hlth Sci Ctr San Antonio, Div Pulm Dis & Crit Care Med, San Antonio, TX 78229 USA

 South Texas Vet Hlth Care Syst, Div Pulm Dis & Crit Care Med, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA

 Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Div Pulm Crit Care Med, San Antonio, TX 78229 USA

Faverio, P:
 Univ Milano Bicocca, San Gerardo Hosp, Resp Unit, Cardiothorac Vasc Dept,ASST Monza, Monza, Italy

Sadud, RF:
 Med Coll Wisconsin, Sect Hosp Med, Milwaukee, WI 53226 USA

 Cook Cty Hosp, Div Hosp Med, Chicago, IL 60612 USA

Muhammad, I:
 Aga Khan Univ, Dept Med, Sect Pulm & Crit Care Med, Karachi 74800, Pakistan

:
 Hosp Badalona Germans Trias & Pujol, Microbiol Dept, Badalona, Spain

 Univ Autonoma Barcelona, Barcelona, Spain

 Inst Salud Carlos III, CIBER Enfermedades Resp CIBERES, Madrid, Spain

Vendrell, E:
 Hosp Mataro, Intens Care Med, Mataro, Spain

Neves, J:
 Ctr Hosp Porto, Serv Med, P-4099001 Porto, Portugal

Kaimakamis, E:
 G Papanikolaou Gen Hosp Thessaloniki, Intens Care Unit, Thessaloniki, Greece

Feneley, A:
 Univ Hosp Leicester NHS Trust, Leicester, Leics, England

 Univ Leicester, Leicester, Leics, England

Swarnakar, R:
 Getwell Hosp & Res Inst, Nagpur, Maharashtra, India

Franzetti, F:
 Univ Milan, Luigi Sacco Hosp, Div Infect Dis, Dept Biomed & Clin Sci, Milan, Italy

Carugati, M:
 Univ Milan, Luigi Sacco Hosp, Div Infect Dis, Dept Biomed & Clin Sci, Milan, Italy

Morosi, M:
 Univ Milan, Luigi Sacco Hosp, Div Infect Dis, Dept Biomed & Clin Sci, Milan, Italy

Monge, E:
 Univ Milan, Luigi Sacco Hosp, Div Infect Dis, Dept Biomed & Clin Sci, Milan, Italy

Restrepo, MI:
 Univ Texas Hlth Sci Ctr San Antonio, Div Pulm Dis & Crit Care Med, San Antonio, TX 78229 USA

 South Texas Vet Hlth Care Syst, Div Pulm Dis & Crit Care Med, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA

Aruj, PK:
 Univ Hosp Alfredo Lanari, Dept Internal Med, Buenos Aires, DF, Argentina

Attorri, S:
 Hosp Luis Lago Maggiore, Mendoza, Argentina

Barimboim, E:
 Hosp Cent Mendoza, Mendoza, Argentina

Caeiro, JP:
 Hosp Privado Univ, Cordoba, Argentina

Garzon, MI:
 Hosp Privado Univ, Cordoba, Argentina

Cambursano, VH:
 Hosp Rawson, VH Dr Cazaux A Serv Neumol, Cordoba, Argentina

Ceccato, A:
 Hosp Nacl Prof Alejandro Posadas, El Palomar, Buenos Aires, Argentina

Chertcoff, J:
 Buenos Aires British Hosp, Crit Care Unit, Buenos Aires, DF, Argentina

 Buenos Aires British Hosp, Resp Med, Buenos Aires, DF, Argentina

Lascar, F:
 Buenos Aires British Hosp, Crit Care Unit, Buenos Aires, DF, Argentina

 Buenos Aires British Hosp, Resp Med, Buenos Aires, DF, Argentina

Di Tulio, F:
 Buenos Aires British Hosp, Crit Care Unit, Buenos Aires, DF, Argentina

 Buenos Aires British Hosp, Resp Med, Buenos Aires, DF, Argentina

Diaz, AC:
 Hosp Gen Alvear, Mendoza, Argentina

de Vedia, L:
 Hosp Muniz, Resp Intens Care Unit, Buenos Aires, DF, Argentina

Ganaha, MC:
 Hosp Interzonal Gen Agudos Vicente Lopez y Planes, Infect Dis Ward, Buenos Aires, DF, Argentina

Lambert, S:
 Hosp Cruce Alta Complejidad Red, Florencio Varela, Buenos Aires, Argentina

Lopardo, G:
 Hosp Bernardo Houssay, Vicente Lopez, Argentina

Luna, CM:
 Univ Buenos Aires, Hosp Clin, Dept Med, Pulm Med Div, Buenos Aires, DF, Argentina

Malberti, AG:
 Hosp Nuestra Senora del Carmen, Zaragoza, Argentina

Morcillo, N:
 Hosp Zonal Especializado Agudos & Cron Dr Antonio, Vicente Lopez, Buenos Aires, Argentina

Tartara, S:
 Hosp Zonal Especializado Agudos & Cron Dr Antonio, Vicente Lopez, Buenos Aires, Argentina

Pensotti, C:
 Clin Privada Monte Grande, Infect Dis & Infect Control Dept, Buenos Aires, DF, Argentina

Pereyra, B:
 Hosp San Roque, Cordoba, Argentina

Scapellato, PG:
 Hosp DF Santojanni, Infect Dis Dept, Buenos Aires, DF, Argentina

Stagnaro, JP:
 HZGA Mi Pueblo, Florencio Varela, Argentina

Shah, S:
 Austin Hosp, Dept Gen Med, Heidelberg, Vic, Australia

Lotsch, F:
 Med Univ Vienna, Dept Med 1, Div Infect Dis & Trop Med, Vienna, Austria

Thalhammer, F:
 Med Univ Vienna, Dept Med 1, Div Infect Dis & Trop Med, Vienna, Austria

Anseeuw, K:
 ZNA Campus Stuivenberg, Antwerp, Belgium

Francois, CA:
 Erasme Univ Hosp, Anesthesia & Crit Care Dept, Brussels, Belgium

Van Braeckel, E:
 Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium

Vincent, JL:
 Univ Libre Bruxelles, Erasme Univ Hosp, Dept Intens Care, Brussels, Belgium

Djimon, MZ:
 Ctr Hosp Univ HKM Cotonou, Cotonou, Benin

Bashi, J:
 Ctr Hosp Univ HKM Cotonou, Cotonou, Benin

Dodo, R:
 Ctr Hosp Univ HKM Cotonou, Cotonou, Benin

Nouer, SA:
 Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil

Chipev, P:
 Mil Med Acad, Clin Pulm Dis, Sofia, Bulgaria

Encheva, M:
 Mil Med Acad, Clin Pulm Dis, Sofia, Bulgaria

Miteva, D:
 UMHAT St Marina, Varna, Bulgaria

Petkova, D:
 Univ Hosp Varna, Varna, Bulgaria

Balkissou, AD:
 Yaounde Jamot Hosp, Yaounde, Cameroon

Yone, EWP:
 Univ Yaounde, Dept Med Interne, Yaounde, Cameroon

Ngahane, BHM:
 Douala Gen Hosp, Douala, Cameroon

Shen, N:
 Peking Univ, Hosp 3, Resp Med, Beijing, Peoples R China

Xu, JF:
 Tongji Univ, Shanghai Pulm Hosp, Dept Resp Med, Shanghai, Peoples R China

Rico, CAB:
 Clin Shaio, Bogota, Colombia

Buitrago, R:
 Clin Shaio, Bogota, Colombia

Paternina, FJP:
 Las Amer Clin, Medellin, Colombia

Ntumba, JMK:
 Clin Univ Kinshasa, Kinshasa, DEM REP CONGO

Carevic, VV:
 Interne Med, Dubrovnik, Croatia

Jakopovic, M:
 Univ Zagreb, Univ Hosp Ctr Zagreb, Med Sch, Dept Resp Dis Jordanovac, Zagreb, Croatia

Jankovic, M:
 Univ Hosp Ctr Zagreb, Dept Resp Dis, Zagreb, Croatia

Matkovic, Z:
 Univ Hosp Dubrava, Zagreb, Croatia

Mitrecic, I:
 Karlovac Gen Hosp, Karlovac, Croatia

Jacobsson, MLB:
 Emergency Dept North Zealands Hosp, Hillerod, Denmark

Christensen, AB:
 Viborg Reg Hosp, Dept Anaethesiol, Viborg, Denmark

Bodtger, UCH:
 Naestved Hosp, Dept Pulmonol, Naestved, Denmark

Meyer, CN:
 Copenhagen Univ Hosp, Roskilde Hosp, Dept Internal Med, Roskilde, Denmark

Jensen, AV:
 Nordsjaellands Hosp, Dept Lung & Infect Dis, Hillerod, Denmark

Baunbaek-knudsen, G:
 Nordsjaellands Hosp, Dept Lung & Infect Dis, Hillerod, Denmark

Petersen, PT:
 Nordsjaellands Hosp, Dept Lung & Infect Dis, Hillerod, Denmark

Andersen, S:
 Nordsjaellands Hosp, Dept Lung & Infect Dis, Hillerod, Denmark

Abd El-Wahhab, IES:
 Mansoura Univ, Fac Med, Thorac Med, Mansoura, Egypt

Morsy, NE:
 Mansoura Univ, Fac Med, Pulm Crit Care & Sleep Med, Mansoura, Egypt

Shafiek, H:
 Alexandria Univ, Fac Med, Chest Dis Dept, Alexandria, Egypt

Sobh, E:
 Al Azhar Univ, Chest Dis Dept, Cairo, Egypt

Abdulsemed, KA:
 Jimma Univ, Inst Biotechnol Res, Mycobacteriol Res Ctr, Dept Med Lab Sci & Pathol,Coll Hlth Sci, Jimma, Ethiopia

Bertrand, F:
 Robert Ballanger Hosp, Crit Care Unit, Aulnay Sous Bois, France

Brun-Buisson, C:
 Univ Hosp Henri Mondor, F-94000 Creteil, France

de Montmollin, E:
 Ctr Hosp St Denis, Hop Delafontaine, Intens Care Unit, St Denis, Reunion, France

Fartoukh, M:
 Grp Hosp Est Parisien, Hop Tenon, Pole Thorax Voies Aeriennes, Unite Reanimat Medicochirurg, Paris, France

Messika, J:
 Hop Louis Mourier, Publ Hop Paris, Serv Reanimat Medicochirurg, Colombes, France

 Univ Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cite, Colombes, France

Tattevin, P:
 Pontchaillou Univ Hosp, Infect Dis & ICU, Rennes, France

Khoury, A:
 Univ Franche Comte, Med Ctr, Dept Emergency Med & Crit Care, Besancon, France

Ebruke, B:
 MRC Unit, Serekunda, Gambia

Dreher, M:
 Univ Hosp Aachen, Dept Cardiol Pneumol Vasc Med & Intens Care Med, Aachen, Germany

Kolditz, M:
 Tech Univ Dresden, Univ Hosp Carl Gustav Cams, Med Dept 1, Div Pulmonol, Dresden, Germany

Meisinger, M:
 Klinikum Niederlausitz GmbH, Klin Innere Med & Intens Med, Senftenberg, Germany

Pletz, MW:
 Jena Univ Hosp, Ctr Infect Dis & Infect Control, Jena, Germany

Hagel, S:
 Jena Univ Hosp, Ctr Infect Dis & Infect Control, Jena, Germany

Rupp, J:
 Univ Lubeck, Dept Mol & Infect Dis, Lubeck, Germany

Schaberg, T:
 Agaples Diakonieklinikum Rotenburg, Zentrum Pneumol, Rotenburg, Germany

Spielmanns, M:
 Univ Witten Herdecke, St Remigius Hosp, Sch Med, Internal Med Dept,Pulm Rehabil, Leverkusen, Germany

 Univ Witten Herdecke, St Remigius Hosp, Sch Med, Dept Hlth, Leverkusen, Germany

Creutz, P:
 Charite, Dept Infect Dis & Resp Med, Berlin, Germany

Suttorp, N:
 Charite, Dept Infect Dis & Resp Med, Berlin, Germany

Siaw-Lartey, B:
 Komfo Anokye Teaching Hosp, Kumasi, Ghana

Dimakou, K:
 SOTIRIA Chest Hosp, Resp Med Dept 5, Athens 11527, Greece

Papapetrou, D:
 Paleo Faliro Clin, Med Grp Athens, Athens, Greece

Tsigou, E:
 Agioi Anargiroi Hosp, Athens, Greece

Ampazis, D:
 Agioi Anargiroi Hosp, Athens, Greece

Bhatia, M:
 SS Hosp IMS BHU Varanasi, Varanasi, Uttar Pradesh, India

Dhar, R:
 Fortis Hosp, Kolkata, India

D'Souza, G:
 St Johns Med Coll Hosp, Dept Pulm Med, Bangalore 560034, Karnataka, India

Garg, R:
 King Georges Med Univ UP, Dept Resp Med, Lucknow, Uttar Pradesh, India

Koul, PA:
 SheriKashmir Inst Med Sci, Dept Internal & Pulm Med, Srinagar, Jammu & Kashmir, India

Mahesh, PA:
 JSS Univ, JSS Med Coll, Dept Pulm Med, Mysore, Karnataka, India

Jayaraj, BS:
 JSS Univ, JSS Med Coll, Dept Pulm Med, Mysore, Karnataka, India

Narayan, KV:
 Govt Med Coll Kozhikode, Pulm Med, Kozhikode, Kerala, India

Udnur, HB:
 Columbia Asia Hosp, Bengaluru, Karnataka, India

Krishnamurthy, SB:
 Columbia Asia Hosp, Bengaluru, Karnataka, India

Kant, S:
 King Georges Med Univ, Dept Resp Med, Lucknow 226003, Uttar Pradesh, India

Limaye, S:
 Chest Res Fdn, Resp Res Network India, Pune, Maharashtra, India

Salvi, S:
 Chest Res Fdn, Resp Res Network India, Pune, Maharashtra, India

Golshani, K:
 Isfahan Univ Med Sci, Esfahan, Iran

Keatings, VM:
 Letterkenny Gen Hosp, Letterkenny, Co Donegal, Ireland

Martin-Loeches, I:
 St James Univ Hosp, Trinity Ctr Hlth Sci Dublin, MICRO, Dublin, Ireland

Maor, Y:
 Tel Aviv Univ, Wolfson Med Ctr, Infect Dis Unit, Holon, Israel

Strahilevitz, J:
 Hadassah Hebrew Univ, Dept Clin Microbiol & Infect Dis, Jerusalem, Israel

Battaglia, S:
 Univ Palermo, Pneumol DiBiMIS, Palermo, Italy

Carrabba, M:
 Fdn IRCCS Ca Granda Osped Maggiore Policlin, Internal Med Dept, I-20122 Milan, Italy

Ceriana, P:
 IRCCS Fdn Maugeri, Pulm Rehabil, I-27100 Pavia, Italy

Confalonieri, M:
 Univ Hosp, Dept Pulmunol, Trieste, Italy

Monforte, AD:
 Univ Milan, Dept Hlth Sci, Clin Infect Dis, San Paolo Hosp, Milan, Italy

Del Prato, B:
 Hosp Antonio Cardarelli, Intervent Pneumol, Naples, Italy

De Rosa, M:
 UOC Pneumol PO San Filippo Neri ASL RM E Roma, Rome, Italy

Fantini, R:
 Policlin Modena, Resp Dis Clin, I-41124 Modena, Italy

Fiorentino, G:
 AO Osped Colli PO Monaldi, UOC Fisiopatol & Riabilitaz Resp, Naples, Italy

Gammino, MA:
 ASL 5 Oristano, San Martino Hosp, Pulm Med Unit, Sardinia, Italy

Menzella, F:
 IRCCS Arcispedale Santa Maria Nuova, Pneumol Unit, Dept Cardiac Thorac Vasc & Intens Care Med, Reggio Emilia, Italy

Milani, G:
 Presidio Osped S Anna Nuovo, Unita Operat Pneumol, Azienda Osped St Anna Como, Como, Italy

Nava, S:
 Alma Mater Univ Bologna, DIMES, Resp & Crit Care Unit, St Orsola Malpighi Hosp, Bologna, Italy

Palmiero, G:
 Azienda USL 12 Viareggio, Versilia Hosp, Resp Unit, Lido Di Camaiore, Lucca, Italy

Petrino, R:
 S Andrea Hosp, Emergency Med Unit, Vercelli, Italy

Gabrielli, B:
 S Andrea Hosp, Emergency Med Unit, Vercelli, Italy

Rossi, P:
 Azienda Osped Univ S Maria della Misericordia, Internal Med Dept, Udine, Italy

Sorino, C:
 AO St Anna Como, Pulmonol Unit, Como, Italy

Steinhilber, G:
 Spedali Civili Brescia, UO Pneumol & Fisiopatol Resp, Brescia, Italy

Zanforlin, A:
 ULSS 18 Rovigo, Osped San Luca, I-45027 Trecenta, RO, Italy

Carone, M:
 Fdn Salvatore Maugeri, IRCCS, Cassano Delle Murge, Italy

Patella, V:
 Battipaglia Hosp, Dept Med Sci, Allergol & Clin Immunol Unit, Salerno, Italy

Scarlata, S:
 Campus Bio Med Univ, Unit Resp Pathophysiol & Thorac Endoscopy, Geriatr, Rome, Italy

 Teaching Hosp, Rome, Italy

Comel, A:
 Osped Pederzoli, UO Pneumol, Peschiera Del Garda, Italy

Kurahashi, K:
 Yokohama City Univ, Med Ctr, Yokohama, Kanagawa, Japan

Bacha, ZA:
 St Joseph Univ, Med Sch, Beirut, Lebanon

Ugalde, DB:
 Natl Inst Resp Dis, Mexico City, DF, Mexico

Zuniga, OC:
 Hosp Gen Mexicali, Mexicali, Baja California, Mexico

Villegas, JF:
 Hosp Univ Monterrey 1, Monterrey 64030, Mexico

Medenica, M:
 Hosp Lung Dis Brezovik, Niksic, Montenegro

van de Garde, EMW:
 St Antonius Hosp, Dept Clin Pharm, Utrecht, Netherlands

Mihsra, DR:
 BP Koirala Inst Hlth Sci, Internal Med, Dharan, Nepal

Shrestha, P:
 Patan Hosp, Oxford Univ Clin Res Unit, Patan, Nepal

Ridgeon, E:
 Med Res Inst New Zealand, Wellington, New Zealand

Awokola, BI:
 Lily Hosp Ltd, Dept Family Med & Primary Care, Warri, Nigeria

Nwankwo, ONO:
 Univ Calabar Teaching Hosp, Calabar, Nigeria

Olufunlola, AB:
 Olabisi Onabanjo Univ Teaching Hosp, Shagamu, Ogun State, Nigeria

Olumide, S:
 Univ Coll Hosp, Pulm Unit, Dept Med, Ibadan, Nigeria

Ukwaja, KN:
 Fed Teaching Hosp Abakaliki, Dept Med, Abakaliki, Ebonyi State, Nigeria

Irfan, M:
 Aga Khan Univ, Dept Med, Sect Pulm & Crit Care Med, Karachi 74800, Pakistan

Minarowski, L:
 Med Univ Bialystok, Dept Lung Dis & TB, Bialystok, Poland

Szymon, S:
 Med Univ Silesia, Sch Med Katowice, Dept Pneumol, Katowice, Poland

 Inst Occupat Med & Environm Hlth, Sosnowiec, Poland

Froes, F:
 Hosp Pulido Valente CHLN, Lisbon, Portugal

Leuschner, P:
 Ctr Hosp Porto, Porto, Portugal

 Kaweah Delta Hlth Care Dist, Dept Emergency Med, Visalia, CA USA

Meireles, M:
 Ctr Hosp Porto, Serv Med, P-4099001 Porto, Portugal

Ferrao, C:
 Ctr Hosp Porto, Serv Med, P-4099001 Porto, Portugal

Ravara, SB:
 Univ Beira Interior, Fac Hlth Sci, Covilha, Portugal

 Cova da Beira Hosp Ctr, P-6200251 Covilha, Portugal

Brocovschii, V:
 State Univ Med & Pharm Nicolae Testemitanu Republ, Dept Pneumol & Allergol, Kishinev, Moldova

Ion, C:
 State Univ Med & Pharm Nicolae Testemitanu Republ, Inst Emergency Med, Clin Anesthesia & Intens Care Valeriu Ghrerg, Kishinev, Moldova

Rusu, D:
 SMFU N Testemitanu, Kishinev, Moldova

Toma, C:
 State Univ Med & Pharm Nicolae Testemitanu, Dept Pneumol & Allergol, Kishinev, Moldova

Chirita, D:
 Hosp Sfantul Stefan, Bucharest, Romania

Dorobat, CM:
 Univ Med Farm Gr T Popa Iasi, Fac Med Stomatol, Spitalul Clin Boli Infect Sfanta Parascheva Iasi, Str Octav Botez 2, Iasi 700116, Romania

Birkun, A:
 Med Acad, Dept Anesthesiol Crit Care & Emergency Med, Simferopol, Russia

Kaluzhenina, A:
 Volgograd State Med Univ, Volgograd, Russia

Almotairi, A:
 KFMC, Riyadh, Saudi Arabia

Bukhary, ZAA:
 Taibah Univ, Coll Med, Medina, Saudi Arabia

Edathodu, J:
 Al Faisal Univ, King Faisal Specialist Hosp, Riyadh, Saudi Arabia

Fathy, A:
 Taibah Univ, Mansoura Univ Egypt, Pulm & Resp Crit Care Med, Medina, Saudi Arabia

Enani, AMA:
 King Fahad Med City, Med Specialties Dept, Infect Dis Sect, Riyadh, Saudi Arabia

Mohamed, NE:
 King Fahad Med City, Med Specialties Dept, Infect Dis Sect, Riyadh, Saudi Arabia

Memon, JU:
 King Fahad Hosp, Dept Internal Med, Pulmonol Div, Al Hufuf 31982, Al Ahasa, Saudi Arabia

Bella, A:
 Dammam Univ Saudi Arabia, Dammam, Saudi Arabia

 King Fahad Hosp, Riyadh, Saudi Arabia

Bogdanovic, N:
 KHC Dr Dragisa Misovic, Pulm Dept, Belgrade, Serbia

Milenkovic, B:
 Univ Belgrade, Fac Med, Clin Ctr Serbia, Clin Pulm Dis, Belgrade, Serbia

Pesut, D:
 Univ Belgrade, Clin Ctr Serbia, Sch Med, Teaching Hosp Pulmonol, Belgrade, Serbia

Borderias, L:
 Hosp San Jorge, Resp & Sleep Unit, Huesca, Spain

Garcia, NMB:
 Barcelona Policlin & Moises Broggi Hosp St Joan D, Barcelona, Spain

Alarcon, HC:
 St Hosp Seu de Urgell, Catalonia, Spain

Cilloniz, C:
 Univ Barcelona, Hosp Clin Barcelona, Dept Pneumol,Inst Clin Torax, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

Torres, A:
 Univ Barcelona, Hosp Clin Barcelona, Dept Pneumol,Inst Clin Torax, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

Diaz-Brito, V:
 Parc Sanitari St Joan de Deu, Infect Dis Unit, Barcelona, Spain

 Parc Sanitari St Joan de Deu, Pneumol Serv, Barcelona, Spain

Casas, X:
 Parc Sanitari St Joan de Deu, Infect Dis Unit, Barcelona, Spain

 Parc Sanitari St Joan de Deu, Pneumol Serv, Barcelona, Spain

Gonzalez, AE:
 Hosp Complex Pontevedra, Pontevedra, Spain

Fernandez-Almira, ML:
 Hosp Univ Cent Asturias, Med Interna, Asturias, Spain

Gallego, M:
 Inst Univ Parc Tauli UAB, Hosp Sabadell, Dept Resp Med, Sabadell, Spain

 CIBERES, CIBER Enfermedades Resp, Bunyola, Spain

Gaspar-Garcia, I:
 Hosp Costa del Sol, Dept Resp Med, Malaga, Spain

del Castillo, JG:
 Hosp Univ Clin San Carlos, Emergency Dept, Madrid, Spain

Victoria, PJ:
 Hosp Gen Univ Alicante, Alicante, Spain

Martinez, EL:
 Hosp Mollet, Barcelona, Spain

de Molina, RM:
 Univ Hosp Puerta de Hierro Majadahonda, Madrid, Spain

Marcos, PJ:
 UAC, INIBIC, Sergas, CHUAC,Serv Neumol, La Coruna, Spain

Menendez, R:
 Univ & Polytech Hosp La Fe, Pneumol Serv, Valencia, Spain

Pando-Sandoval, A:
 Hosp Univ Cent Asturias, Area Gest Clin Pulmon, Serv Neumol, Oviedo, Spain

Aymerich, CP:
 Univ Autonoma Barcelona, Barcelona, Spain

 Inst Salud Carlos III, CIBER Enfermedades Resp CIBERES, Madrid, Spain

 Hosp Badalona Germans Trias & Pujol, Inst Invest Germans Trias & Pujol, Microbiol Dept, Badalona, Spain

 Hosp Badalona Germans Trias & Pujol, Inst Invest Germans Trias & Pujol, Pneumol Dept, Badalona, Spain

:
 Univ Autonoma Barcelona, Barcelona, Spain

 Inst Salud Carlos III, CIBER Enfermedades Resp CIBERES, Madrid, Spain

 Hosp Badalona Germans Trias & Pujol, Inst Invest Germans Trias & Pujol, Microbiol Dept, Badalona, Spain

 Hosp Badalona Germans Trias & Pujol, Inst Invest Germans Trias & Pujol, Pneumol Dept, Badalona, Spain

:
 Univ Autonoma Barcelona, Barcelona, Spain

 Inst Salud Carlos III, CIBER Enfermedades Resp CIBERES, Madrid, Spain

 Hosp Badalona Germans Trias & Pujol, Inst Invest Germans Trias & Pujol, Microbiol Dept, Badalona, Spain

 Hosp Badalona Germans Trias & Pujol, Inst Invest Germans Trias & Pujol, Pneumol Dept, Badalona, Spain

Rello, J:
 Hosp Valle De Hebron, Crit Care Dept, Barcelona, Spain

Moyano, S:
 Hosp Valle De Hebron, Crit Care Dept, Barcelona, Spain

Sibila, O:
 Hosp Santa Creu & Sant Pau, IIB St Pau, Servei Pneumol, Barcelona, Spain

Rodrigo-Troyano, A:
 Hosp Santa Creu & Sant Pau, IIB St Pau, Servei Pneumol, Barcelona, Spain

Sole-Violan, J:
 Hosp Univ Gran Canaria Dr Negrin, Las Palmas Gran Canaria, Spain

Uranga, A:
 Hosp Galdakao Usansolo, Pulmol Dept, Galdakao, Bizkaia, Spain

van Boven, JFM:
 Hosp Univ Son Espases, Palma De Mallorca, Spain

Torra, EV:
 Hosp Mataro, Intens Care Med, Mataro, Spain

Pujol, JA:
 Hosp Mataro, Intens Care Med, Mataro, Spain

Feldman, C:
 Univ Witwatersrand, Fac Hlth Sci, Charlotte Maxeke Johannesburg Acad Hosp, Div Pulmonol,Dept Internal Med, Johannesburg, South Africa

Yum, HK:
 Inje Univ, Seoul Paik Hosp, Seoul, South Korea

Fiogbe, AA:
 Univ Hosp Sylvanus Olympio, Pulmonol & Infect Dis Serv, Lome, Togo

Yangui, F:
 Hosp Internal Forces Secur IFS, Dept Pneumol, Tunis, Tunisia

Bilaceroglu, S:
 Izmir Dr Suat Seren Training & Res Hosp Thorac Me, Izmir, Turkey

Dalar, L:
 Istanbul Bil Univ, Pulm Med, Istanbul, Turkey

Yilmaz, U:
 Suat Seren Chest Dis & Surg Training & Res Hosp, Izmir, Turkey

Bogomolov, A:
 Vinnitsa Natl Pirogov Mem Med Univ, Vinnitsa Reg Antitb Hosp, Vinnitsa, Ukraine

Elahi, N:
 Dubai Hosp, Dubai, U Arab Emirates

Dhasmana, DJ:
 NHS Fife, Victoria Hosp, Kirkcaldy, Fife, Scotland

Ions, R:
 Univ Hosp Leicester NHS Trust, Leicester, Leics, England

 Univ Leicester, Leicester, Leics, England

Skeemer, J:
 Univ Hosp Leicester NHS Trust, Leicester, Leics, England

 Univ Leicester, Leicester, Leics, England

Woltmann, G:
 Univ Hosp Leicester NHS Trust, Leicester, Leics, England

 Univ Leicester, Leicester, Leics, England

Hancock, C:
 Royal Liverpool Univ Hosp, Royal Resp Res Team, Liverpool, Merseyside, England

Hill, AT:
 Royal Infirm, Edinburgh, Midlothian, Scotland

 Univ Edinburgh, Edinburgh, Midlothian, Scotland

Rudran, B:
 Barts Hlth Trust, Royal London Hosp, London, England

Ruiz-Buitrago, S:
 Hairmyres Hosp, Eaglesham Rd, East Kilbride G75 8RG, Scotland

Campbell, M:
 Hairmyres Hosp, Eaglesham Rd, East Kilbride G75 8RG, Scotland

Whitaker, P:
 St James Hosp, Dept Resp Med, Leeds LS9 7TF, W Yorkshire, England

Youzguin, A:
 Southport & Ormskirk Hosp NHS Trust, Southport, England

Singanayagam, A:
 Imperial Coll Healthcare NHS Trust, London, England

Allen, KS:
 Univ Oklahoma, Hlth Sci Ctr, Norman, OK 73019 USA

Brito, V:
 Parc Sanitari St Joan de Deu, Infect Dis Unit, Barcelona, Spain

 Parc Sanitari St Joan de Deu, Pneumol Serv, Barcelona, Spain

 Baylor Scott & White Hlth, Div Pulm Crit Care & Sleep Med, Texas A&M Hlth Sci Ctr, Temple, TX USA

Dietz, J:
 Fargo VA Hlth Care Syst, Fargo, ND USA

Dysart, CE:
 Clement J Zablocki VA Med Ctr, 5000 W Natl Ave, Milwaukee, WI 53295 USA

 Univ New Mexico, Div Infect Dis, Sch Med, Raymond G Murphy VA Med Ctr, 1501 San Pedro SE, Albuquerque, NM 87108 USA

Kellie, SM:
 Clement J Zablocki VA Med Ctr, 5000 W Natl Ave, Milwaukee, WI 53295 USA

 Univ New Mexico, Div Infect Dis, Sch Med, Raymond G Murphy VA Med Ctr, 1501 San Pedro SE, Albuquerque, NM 87108 USA

Meier, G:
 Cook Cty Hosp, Div Hosp Med, Chicago, IL 60612 USA

Gaga, M:
 Athens Chest Hosp, Resp Med Dept 7, Athens, Greece

 Athens Chest Hosp, Asthma Ctr, Athens, Greece

Holland, TL:
 Duke Univ, Dept Med, Med Ctr, Durham, NC 27706 USA

 Duke Clin Res Inst, Sch Med, Durham, NC USA

Bergin, SP:
 Duke Univ, Dept Med, Med Ctr, Durham, NC 27706 USA

 Duke Clin Res Inst, Sch Med, Durham, NC USA

Kheir, F:
 Tulane Univ, Hlth Sci Ctr, Dept Pulm Dis Crit Care & Environm Med, New Orleans, LA 70118 USA

Landmeier, M:
 Northwestern Mem Hosp, Div Pulm & Crit Care Med, Chicago, IL 60611 USA

 John Peter Smith Hosp, Ft Worth, TX 76104 USA

Nair, GB:
 SUNY Stony Brook, Winthrop Univ Hosp, Interstitial Lung Dis Programand Pulm Rehabil, Mineola, NY 11501 USA

Patel, H:
 Univ Colorado, Hosp Med Grp, Dept Med, Div Gen Internal Med, Boulder, CO 80309 USA

Reyes, K:
 Henry Ford Hosp, Detroit, MI 48202 USA

Rodriguez-Cintron, W:
 VA Caribbean Healthcare Syst, Pulm Crit Care Med, San Juan, PR USA

Saito, S:
 Tulane Univ, New Orleans, LA 70118 USA

Noda, J:
 Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Div Hosp Med, San Antonio, TX 78229 USA

 Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Div Pulm Crit Care Med, San Antonio, TX 78229 USA

Hinojosa, CI:
 Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Div Hosp Med, San Antonio, TX 78229 USA

 Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Div Pulm Crit Care Med, San Antonio, TX 78229 USA

Levine, SM:
 Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Div Hosp Med, San Antonio, TX 78229 USA

 Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Div Pulm Crit Care Med, San Antonio, TX 78229 USA

Angel, LF:
 Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Div Hosp Med, San Antonio, TX 78229 USA

 Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, Div Pulm Crit Care Med, San Antonio, TX 78229 USA

Whitlow, KS:
 Kaweah Delta Hlth Care Dist, Dept Emergency Med, Visalia, CA USA

Hipskind, J:
 Kaweah Delta Hlth Care Dist, Dept Emergency Med, Visalia, CA USA

Sukhija, K:
 Kaweah Delta Hlth Care Dist, Dept Emergency Med, Visalia, CA USA

Totten, V:
 Kaweah Delta Hlth Care Dist, Dept Emergency Med, Visalia, CA USA

Wunderink, RG:
 Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

Shah, RD:
 Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

Mateyo, KJ:
 Univ Teaching Hosp, Dept Internal Med, Lusaka, Zambia
ISSN: 01634453





Journal of Infection
Editorial
W. B. Saunders Co., Ltd., 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 79 Número: 4
Páginas: 300-311
WOS Id: 000486605900002
ID de PubMed: 31299410
imagen Green Accepted

MÉTRICAS