Effect of Polyphenols Intake on Obesity-Induced Maternal Programming
Por:
Fortunato, IM, dos Santos, TW, Ferraz, LFC, Santos, JC and Ribeiro, ML
Publicada:
1 jul 2021
Ahead of Print:
13 jul 2021
Resumen:
Excess caloric intake and body fat accumulation lead to obesity, a complex chronic disease that represents a significant public health problem due to the health-related risk factors. There is growing evidence showing that maternal obesity can program the offspring, which influences neonatal phenotype and predispose offspring to metabolic disorders such as obesity. This increased risk may also be epigenetically transmitted across generations. Thus, there is an imperative need to find effective reprogramming approaches in order to resume normal fetal development. Polyphenols are bioactive compounds found in vegetables and fruits that exert its anti-obesity effect through its powerful anti-oxidant and anti-inflammatory activities. Polyphenol supplementation has been proven to counteract the prejudicial effects of maternal obesity programming on progeny. Indeed, some polyphenols can cross the placenta and protect the fetal predisposition against obesity. The present review summarizes the effects of dietary polyphenols on obesity-induced maternal reprogramming as an offspring anti-obesity approach.
Filiaciones:
Fortunato, IM:
Univ Sao Francisco USF, Post Grad Program Hlth Sci, BR-12916900 Braganca Paulista, SP, Brazil
dos Santos, TW:
Univ Sao Francisco USF, Post Grad Program Hlth Sci, BR-12916900 Braganca Paulista, SP, Brazil
Ferraz, LFC:
Univ Sao Francisco USF, Post Grad Program Hlth Sci, BR-12916900 Braganca Paulista, SP, Brazil
:
Josep Carreras Leukemia Res Inst IJC, Lymphoma Translat Grp, Badalona 08916, Spain
Ribeiro, ML:
Univ Sao Francisco USF, Post Grad Program Hlth Sci, BR-12916900 Braganca Paulista, SP, Brazil
Green Published, Green Submitted
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