Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen


Por: Menden, MP, Wang, D, Mason, MJ, Szalai, B, Bulusu, KC, Guan, YF, Yu, T, Kang, J, Jeon, M, Wolfinger, R, Nguyen, T, Zaslavskiy, M, Jang, IS, Ghazoui, Z, Ahsen, ME, Vogel, R, Neto, EC, Norman, T, Tang, EKY, Garnett, MJ, Di Veroli, GY, Fawell, S, Stolovitzky, G, Guinney, J, Dry, JR, Saez-Rodriguez, J, Abante, J, Abecassis, BS, Aben, N, Aghamirzaie, D, Aittokallio, T, Akhtari, FS, Al-lazikani, B, Alam, T, Allam, A, Allen, C, de Almeida, MP, Altarawy, D, Alves, V, Amadoz, A, Anchang, B, Antolin, AA, Ash, JR, Aznar, VR, Ba-alawi, W, Bagheri, M, Bajic, V, Ball, G, Ballester, PJ, Baptista, D, Bare, C, Bateson, M, Bender, A, Bertrand, D, Wijayawardena, B, Boroevich, KA, Bosdriesz, E, Bougouffa, S, Bounova, G, Brouwer, T, Bryant, B, Calaza, M, Calderone, A, Calza, S, Capuzzi, S, Carbonell-Caballero, J, Carlin, D, Carter, H, Castagnoli, L, Celebi, R, Cesareni, G, Chang, H, Chen, GC, Chen, HR, Chen, HY, Cheng, LJ, Chernomoretz, A, Chicco, D, Cho, KH, Cho, S, Choi, D, Choi, J, Choi, K, Choi, M, De Cock, M, Coker, E, Cortes-Ciriano, I, Cserzo, M, Cubuk, C, Curtis, C, Van Daele, D, Dang, CC, Dijkstra, T, Dopazo, J, Draghici, S, Drosou, A, Dumontier, M, Ehrhart, F, Eid, FE, ElHefnawi, M, Elmarakeby, H, van Engelen, B, Engin, HB, de Esch, I, Evelo, C, Falcao, AO, Farag, S, Fernandez-Lozano, C, Fisch, K, Flobak, A, Fornari, C, Foroushani, ABK, Fotso, DC, Fourches, D, Friend, S, Frigessi, A, Gao, F, Gao, XT, Gerold, JM, Gestraud, P, Ghosh, S, Gillberg, J, Godoy-Lorite, A, Godynyuk, L, Godzik, A, Goldenberg, A, Gomez-Cabrero, D, Gonen, M, de Graaf, C, Gray, H, Grechkin, M, Guimera, R, Guney, E, Haibe-Kains, B, Han, Y, Hase, T, He, D, He, LY, Heath, LS, Hellton, KH, Helmer-Citterich, M, Hidalgo, MR, Hidru, D, Hill, SM, Hochreiter, S, Hong, S, Hovig, E, Hsueh, YC, Hu, ZY, Huang, JK, Huang, RS, Hunyady, L, Hwang, J, Hwang, TH, Hwang, W, Hwang, Y, Isayev, O, Walk, OBD, Jack, J, Jahandideh, S, Ji, JD, Jo, Y, Kamola, PJ, Kanev, GK, Karacosta, L, Karimi, M, Kaski, S, Kazanov, M, Khamis, AM, Khan, SA, Kiani, NA, Kim, A, Kim, J, Kim, J, Kim, K, Kim, K, Kim, S, Kim, Y, Kim, Y, Kirk, PDW, Kitano, H, Klambauer, G, Knowles, D, Ko, M, Kohn-Luque, A, Kooistra, AJ, Kuenemann, MA, Kuiper, M, Kurz, C, Kwon, M, van Laarhoven, T, Laegreid, A, Lederer, S, Lee, H, Lee, J, Lee, YW, Leppaho, E, Lewis, R, Li, J, Li, L, Liley, J, Lim, WK, Lin, C, Liu, YY, Lopez, Y, Low, J, Lysenko, A, Machado, D, Madhukar, N, De Maeyer, D, Malpartida, AB, Mamitsuka, H, Marabita, F, Marchal, K, Marttinen, P, Mason, D, Mazaheri, A, Mehmood, A, Mehreen, A, Michaut, M, Miller, RA, Mitsopoulos, C, Modos, D, Van Moerbeke, M, Moo, K, Motsinger-Reif, A, Movva, R, Muraru, S, Muratov, E, Mushthofa, M, Nagarajan, N, Nakken, S, Nath, A, Neuvial, P, Newton, R, Ning, Z, De Niz, C, Oliva, B, Olsen, C, Palmeri, A, Panesar, B, Papadopoulos, S, Park, J, Park, S, Park, S, Pawitan, Y, Peluso, D, Pendyala, S, Peng, J, Perfetto, L, Pirro, S, Plevritis, S, Politi, R, Poon, H, Porta, E, Prellner, I, Preuer, K, Pujana, MA, Ramnarine, R, Reid, JE, Reyal, F, Richardson, S, Ricketts, C, Rieswijk, L, Rocha, M, Rodriguez-Gonzalvez, C, Roell, K, Rotroff, D, de Ruiter, JR, Rukawa, P, Sadacca, B, Safikhani, Z, Safitri, F, Sales-Pardo, M, Sauer, S, Schlichting, M, Seoane, JA, Serra, J, Shang, MM, Sharma, A, Sharma, H, Shen, Y, Shiga, M, Shin, M, Shkedy, Z, Shopsowitz, K, Sinai, S, Skola, D, Smirnov, P, Soerensen, IF, Soerensen, P, Song, JH, Song, SO, Soufan, O, Spitzmueller, A, Steipe, B, Suphavilai, C, Tamayo, SP, Tamborero, D, Tang, J, Tanoli, ZUR, Tarres-Deulofeu, M, Tegner, J, Thommesen, L, Tonekaboni, SAM, Tran, H, De Troyer, E, Truong, A, Tsunoda, T, Turu, G, Tzeng, GY, Verbeke, L, Videla, S, Vis, D, Voronkov, A, Votis, K, Wang, A, Wang, HQH, Wang, PW, Wang, S, Wang, W, Wang, XC, Wang, X, Wennerberg, K, Wernisch, L, Wessels, L, van Westen, GJP, Westerman, BA, White, SR, Willighagen, E, Wurdinger, T, Xie, L, Xie, SL, Xu, H, Yadav, B, Yau, C, Yeerna, H, Yin, JW, Yu, M, Yu, M, Yun, SJ, Zakharov, A, Zamichos, A, Zanin, M, Zeng, L, Zenil, H, Zhang, F, Zhang, PY, Zhang, W, Zhao, HY, Zhao, L, Zheng, WJ, Zoufir, A and Zucknick, M

Publicada: 17 jun 2019
Resumen:
The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca's large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.

Filiaciones:
Menden, MP:
 AstraZeneca, IMED Biotech Unit, Oncol, Cambridge SG8 6EH, England

 European Bioinformat Inst, European Mol Biol Lab, Cambridge CB10 1SD, England

 Helmholtz Zentrum MUnchen, Inst Computat Biol, German Res Ctr Environm Hlth, D-85764 Munich, Germany

Wang, D:
 AstraZeneca, IMED Biotech Unit, Oncol, Cambridge SG8 6EH, England

 Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield S10 2TN, S Yorkshire, England

Mason, MJ:
 Sage Bionetworks, Seattle, WA 98121 USA

Szalai, B:
 Semmelweis Univ, Fac Med, Dept Physiol, H-1085 Budapest, Hungary

 Hungarian Acad Sci, Lab Mol Physiol, H-1085 Budapest, Hungary

 Semmelweis Univ MTA SE, H-1085 Budapest, Hungary

 Rhein Westfal TH Aachen, Fac Med, Joint Res Ctr Computat Biomed, D-52062 Aachen, Germany

Bulusu, KC:
 AstraZeneca, IMED Biotech Unit, Oncol, Cambridge SG8 6EH, England

Guan, YF:
 Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

Yu, T:
 Sage Bionetworks, Seattle, WA 98121 USA

Kang, J:
 Korea Univ, Dept Comp Sci & Engn, Seoul 02841, South Korea

Jeon, M:
 Korea Univ, Dept Comp Sci & Engn, Seoul 02841, South Korea

Wolfinger, R:
 SAS Inst Inc, Cary, NC 27513 USA

Nguyen, T:
 Univ Nevada, Dept Comp Sci & Engn, Reno, NV 89557 USA

Zaslavskiy, M:
 Owkin Inc, Computat Biol, New York, NY 10022 USA

Jang, IS:
 Sage Bionetworks, Seattle, WA 98121 USA

Ghazoui, Z:
 AstraZeneca, IMED Biotech Unit, Oncol, Cambridge SG8 6EH, England

Ahsen, ME:
 IBM Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA

Vogel, R:
 IBM Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA

Neto, EC:
 Sage Bionetworks, Seattle, WA 98121 USA

Norman, T:
 Sage Bionetworks, Seattle, WA 98121 USA

Tang, EKY:
 AstraZeneca, IMED Biotech Unit, Oncol, Cambridge SG8 6EH, England

Garnett, MJ:
 Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England

Di Veroli, GY:
 AstraZeneca, IMED Biotech Unit, Early Clin Dev, Cambridge SG8 6EH, England

Fawell, S:
 R&D Boston, AstraZeneca, IMED Biotech Unit, Oncol, Waltham, MA 02451 USA

Stolovitzky, G:
 IBM Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA

 Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

Guinney, J:
 Sage Bionetworks, Seattle, WA 98121 USA

Dry, JR:
 R&D Boston, AstraZeneca, IMED Biotech Unit, Oncol, Waltham, MA 02451 USA

Saez-Rodriguez, J:
 European Bioinformat Inst, European Mol Biol Lab, Cambridge CB10 1SD, England

 Rhein Westfal TH Aachen, Fac Med, Joint Res Ctr Computat Biomed, D-52062 Aachen, Germany

 Heidelberg Univ, Fac Med, Inst Computat Biomed, D-69120 Heidelberg, Germany

Abante, J:
 Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA

Abecassis, BS:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Aben, N:
 Div Mol Carcinogenesis NKI, NL-1066 CX Amsterdam, Netherlands

 Delft Univ Technol, Fac EEMCS, NL-2628 CD Delft, Netherlands

Aghamirzaie, D:
 Virginia Tech, Genet Bioinformat & Computat Biol, Blacksburg, VA 24061 USA

Aittokallio, T:
 Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland

Akhtari, FS:
 North Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA

Al-lazikani, B:
 Inst Canc Res, London SW3 6JB, England

Alam, T:
 KAUST, CBRC, Thuwal 23955, Saudi Arabia

Allam, A:
 KAUST, Thuwal 23955, Saudi Arabia

Allen, C:
 Univ Cambridge, Ctr Mol Informat, Dept Chem, Cambridge CB2 1EW, England

de Almeida, MP:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Altarawy, D:
 Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA

 Alexandria Univ, Alexandria 21500, Egypt

Alves, V:
 Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

Amadoz, A:
 Igenomix SL, Dept Bioinformat, Valencia 46980, Spain

Anchang, B:
 Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

Antolin, AA:
 Inst Canc Res, London SW3 6JB, England

Ash, JR:
 North Carolina State Univ, Bioinformat Res Ctr, Dept Chem, Dept Stat, Raleigh, NC 27695 USA

Aznar, VR:
 Leloir Inst, C1405 BWE, Buenos Aires, DF, Argentina

Ba-alawi, W:
 KAUST, CBRC, Thuwal 23955, Saudi Arabia

Bagheri, M:
 Univ Toronto, Toronto, ON M5S, Canada

Bajic, V:
 KAUST, CBRC, Thuwal 23955, Saudi Arabia

Ball, G:
 Karolinska Inst, Dept Med, Unit Computat Med, Solna SciLifeLab,Ctr Mol Med, SE-17176 Solna, Sweden

Ballester, PJ:
 INSERM U1068, F-13005 Marseille, France

 Inst Paoli Calmettes, F-13009 Marseille, France

 Aix Marseille Univ, F-13007 Marseille, France

 CNRS UMR7258, F-13273 Marseille, France

Baptista, D:
 Univ Minho, Ctr Biol Engn CEB, P-4710057 Braga, Portugal

Bare, C:
 Sage Bionetworks, Seattle, WA 98121 USA

Bateson, M:
 Inst HyperCube, F-92907 Paris, France

Bender, A:
 Univ Cambridge, Ctr Mol Informat, Dept Chem, Cambridge CB2 1EW, England

Bertrand, D:
 Genome Inst Singapore, Computat & Syst Biol, Singapore 138672, Singapore

Wijayawardena, B:
 Indiana Univ, Sch Med, Indianapolis, IN 46202 USA

Boroevich, KA:
 RIKEN Japan, Ctr Integrat Med Sci, Kobe, Hyogo 6500047, Japan

Bosdriesz, E:
 Div Mol Carcinogenesis NKI, NL-1066 CX Amsterdam, Netherlands

 Canc Genom Netherlands, NL-3584 CG Utrecht, Netherlands

Bougouffa, S:
 KAUST, CBRC, Thuwal 23955, Saudi Arabia

Bounova, G:
 Div Mol Carcinogenesis NKI, NL-1066 CX Amsterdam, Netherlands

Brouwer, T:
 Univ Cambridge, Comp Lab, Cambridge CB3 OFD, England

Bryant, B:
 Constellat Pharmaceut, Cambridge, MA 02142 USA

Calaza, M:
 CIMUS Univ Santiago Compostela, La Coruna 15001, Spain

Calderone, A:
 Univ Roma Tor Vergata, Dept Biol, Bioinformat & Computat Biol Unit, I-00133 Rome, Italy

Calza, S:
 Univ Brescia, Dept Mol & Translat Med, I-25123 Brescia, Italy

 Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17176 Stockholm, Sweden

Capuzzi, S:
 Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

Carbonell-Caballero, J:
 Barcelona Inst Sci & Technol, CRG, Barcelona 08036, Spain

Carlin, D:
 Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Carter, H:
 Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Castagnoli, L:
 Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Celebi, R:
 Ege Univ Turkey, Dept Comp Engn, TR-35100 Metro Istasyonu, Turkey

Cesareni, G:
 Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Chang, H:
 Korea Univ, Dept Comp Sci & Engn, Seoul 02841, South Korea

Chen, GC:
 Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA

Chen, HR:
 Texas A&M Univ, College Stn, TX 77843 USA

Chen, HY:
 Case Western Univ, Cleveland, OH 44106 USA

Cheng, LJ:
 Indiana Univ, Sch Med, Indianapolis, IN 46202 USA

Chernomoretz, A:
 Leloir Inst, C1405 BWE, Buenos Aires, DF, Argentina

Chicco, D:
 Princess Margaret Canc Ctr, Toronto, ON M5G 2C1, Canada

Cho, KH:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

Cho, S:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

Choi, D:
 Kongju Natl Univ, Dept Med Informat, Gongju 32588, South Korea

Choi, J:
 Biosynergy Res Ctr, Daejeon 02451, South Korea

Choi, K:
 Korea Univ, Dept Comp Sci & Engn, Seoul 02841, South Korea

Choi, M:
 Kongju Natl Univ, Dept Med Informat, Gongju 32588, South Korea

De Cock, M:
 Univ Washington, Tacoma, WA 98402 USA

Coker, E:
 Inst Canc Res, London SW3 6JB, England

Cortes-Ciriano, I:
 Inst Pasteur, CNRS UMR, Unite Bioinformat Struct, Dept Biol Struct & Chim, F-3825 Paris, France

Cserzo, M:
 Semmelweis Univ, Fac Med, Dept Physiol, H-1085 Budapest, Hungary

 Hungarian Acad Sci, Lab Mol Physiol, H-1085 Budapest, Hungary

 Semmelweis Univ MTA SE, H-1085 Budapest, Hungary

Cubuk, C:
 Hosp Virgen Rocio, Clin Bioinformat Area Fdn Progreso & Salud CDCA, Seville 41092, Spain

Curtis, C:
 Stanford Univ, Stanford, CA 94305 USA

Van Daele, D:
 Katholieke Univ Leuven, B-3000 Leuven, Belgium

Dang, CC:
 INSERM U1068, F-13005 Marseille, France

 Inst Paoli Calmettes, F-13009 Marseille, France

 Aix Marseille Univ, F-13007 Marseille, France

 CNRS UMR7258, F-13273 Marseille, France

Dijkstra, T:
 Max Planck Inst Dev Biol, D-72076 Tubingen, Germany

Dopazo, J:
 Hosp Virgen Rocio, Clin Bioinformat Area Fdn Progreso & Salud CDCA, Seville 41092, Spain

Draghici, S:
 Wayne State Univ, Dept Comp Sci, Detroit, MI 48202 USA

 Wayne State Univ, Dept Obstet & Gynecol, Detroit, MI 48202 USA

Drosou, A:
 CERTH ITI, GR-5700 Thessaloniki, Greece

Dumontier, M:
 Maastricht Univ, Inst Data Sci, NL-6229 ER Maastricht, Netherlands

Ehrhart, F:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Eid, FE:
 Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA

 Al Azhar Univ, Cairo 11651, Egypt

ElHefnawi, M:
 Natl Res Ctr, Cairo 12622, Egypt

 Nile Univ, Cairo 12622, Egypt

Elmarakeby, H:
 Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA

 Al Azhar Univ, Cairo 11651, Egypt

van Engelen, B:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Engin, HB:
 Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

de Esch, I:
 AIMMS Vrije Univ, Div Med Chem, NL-1081 HZ Amsterdam, Netherlands

Evelo, C:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Falcao, AO:
 Univ Lisboa Portugal, LaSIGE Fac Ciencias, P-1749016 Lisbon, Portugal

Farag, S:
 Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

Fernandez-Lozano, C:
 Univ A Coruna, Coruna 15001, Spain

Fisch, K:
 Univ Calif San Diego, Ctr Computat Biol & Bioinformat, La Jolla, CA 92093 USA

Flobak, A:
 Norwegian Univ Sci & Technol, N-7491 Trondheim, Norway

 St Olavs Univ Hosp, N-7030 Trondheim, Norway

Fornari, C:
 AstraZeneca, IMED Biotech Unit, Oncol, Cambridge SG8 6EH, England

Foroushani, ABK:
 Texas State Univ, San Marcos, TX 78666 USA

Fotso, DC:
 Univ Oxford, Oxford OX1 2JD, England

Fourches, D:
 North Carolina State Univ, Dept Chem, Bioinformat Res Ctr, Raleigh, NC 27695 USA

Friend, S:
 Sage Bionetworks, Seattle, WA 98121 USA

Frigessi, A:
 Univ Oslo, Oslo Ctr Biostat & Epidemiol, N-0317 Oslo, Norway

 Oslo Univ Hosp Norway, N-0317 Oslo, Norway

Gao, F:
 City Univ Hong Kong, Dept Biomed Sci, Hong Kong 999077, Peoples R China

Gao, XT:
 Yale Univ, New Haven, CT 06520 USA

Gerold, JM:
 Harvard Univ, Program Evolutionary Dynam, Cambridge, MA 02138 USA

Gestraud, P:
 Inst Curie, Inserm U900, F-75248 Paris, France

Ghosh, S:
 Syst Biol Inst Tokyo, Tokyo 1410022, Japan

Gillberg, J:
 Aalto Univ, Dept Comp Sci, Espoo 02150, Finland

Godoy-Lorite, A:
 Quim Univ Rovira & Virgili, Dept Engn, Tarragona 43007, Spain

Godynyuk, L:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Godzik, A:
 Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA 92037 USA

Goldenberg, A:
 Hosp Sick Children, Toronto, ON M5G 1X8, Canada

Gomez-Cabrero, D:
 Karolinska Inst, Dept Med, Unit Computat Med, Solna SciLifeLab,Ctr Mol Med, SE-17176 Solna, Sweden

 Kings Coll London, Mucosal & Salivary Biol Div, Dent Inst, London SE1 9RT, England

Gonen, M:
 Koc Univ, Coll Engn, TR-34450 Istanbul, Turkey

 Koc Univ, Sch Med, TR-34450 Istanbul, Turkey

de Graaf, C:
 AIMMS Vrije Univ, Div Med Chem, NL-1081 HZ Amsterdam, Netherlands

Gray, H:
 Univ Cambridge, MRC Biostat Unit, Cambridge CB2 0SR, England

Grechkin, M:
 Univ Washington, Seattle, WA 98195 USA

Guimera, R:
 Quim Univ Rovira & Virgili, Dept Engn, Tarragona 43007, Spain

 ICREA, Barcelona 08010, Spain

Guney, E:
 Inst Res Biomed, Joint & RB BSC CRG Program Computat Biol, Barcelona 08028, Spain

Haibe-Kains, B:
 Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 2C1, Canada

Han, Y:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

Hase, T:
 Syst Biol Inst Tokyo, Tokyo 1410022, Japan

He, D:
 CUNY, Grad Ctr, PhD Program Comp Sci, New York, NY USA

He, LY:
 Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland

Heath, LS:
 Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA

Hellton, KH:
 Univ Oslo, Dept Math, N-0371 Oslo, Norway

Helmer-Citterich, M:
 Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Hidalgo, MR:
 Hosp Virgen Rocio, Clin Bioinformat Area Fdn Progreso & Salud CDCA, Seville 41092, Spain

Hidru, D:
 Univ Toronto, Toronto, ON M5S, Canada

Hill, SM:
 Univ Cambridge, MRC Biostat Unit, Cambridge CB2 0SR, England

Hochreiter, S:
 Johannes Kepler Univ Linz, Inst Machine Learning Johannes Kepler, A-4040 Linz, Austria

Hong, S:
 Univ Wisconsin, Madison, WI 53706 USA

Hovig, E:
 Oslo Univ Hosp Norway, Inst Canc Res, Dept Tumor Biol, N-0424 Oslo, Norway

 Univ Oslo, Dept Informat, N-0316 Oslo, Norway

Hsueh, YC:
 Univ Toronto, Toronto, ON M5S, Canada

Hu, ZY:
 Univ Oxford, Wellcome Trust, Ctr Human Genet, Oxford OX3 7BN, England

Huang, JK:
 Univ Calif San Diego, Bioinformat & Syst Biol Program, La Jolla, CA 92093 USA

Huang, RS:
 Univ Minnesota, Minneapolis, MN 55455 USA

Hunyady, L:
 Semmelweis Univ, Fac Med, Dept Physiol, H-1085 Budapest, Hungary

 Hungarian Acad Sci, Lab Mol Physiol, H-1085 Budapest, Hungary

 Semmelweis Univ MTA SE, H-1085 Budapest, Hungary

Hwang, J:
 Daegu Univ, Dept Comp Sci & Stat, Daegu 38453, South Korea

Hwang, TH:
 Univ Texas Southwestern Med Ctr Dallas, Dept Bioinformat, Dallas, TX 75390 USA

Hwang, W:
 Biosynergy Res Ctr, Daejeon 02451, South Korea

Hwang, Y:
 Univ Suwon, Dept Comp Sci, Suwon 16499, South Korea

Isayev, O:
 Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

Walk, OBD:
 Columbia Univ, Dept Biomed Informat, New York, NY 10032 USA

Jack, J:
 North Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA

Jahandideh, S:
 Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA 92037 USA

Ji, JD:
 Univ Finance & Econ, Sch Stat Shandong, Jinan 250000, Shandong, Peoples R China

 CUNY, Hunter Coll, Dept Comp Sci, New York, NY 10065 USA

 Shandong Univ China, Sch Publ Hlth, Dept Biostat, Jinan 250012, Shandong, Peoples R China

Jo, Y:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

Kamola, PJ:
 RIKEN Japan, Ctr Integrat Med Sci, Kobe, Hyogo 6500047, Japan

Kanev, GK:
 AIMMS Vrije Univ, Div Med Chem, NL-1081 HZ Amsterdam, Netherlands

Karacosta, L:
 Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

Karimi, M:
 Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA

Kaski, S:
 Aalto Univ, Dept Comp Sci, Espoo 02150, Finland

Kazanov, M:
 Skolkovo Inst Sci & Technol, Moscow 121205, Russia

 AA Kharkevich Inst Informat Transmiss Problems, Moscow 127051, Russia

Khamis, AM:
 KAUST, CBRC, Thuwal 23955, Saudi Arabia

Khan, SA:
 Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland

Kiani, NA:
 Karolinska Inst, Ctr Mol Med, SciLifeLab, Algorithm Dynam Lab,Unit Computat Med,Dept Med So, SE-17176 Solna, Sweden

Kim, A:
 Univ Washington, Seattle, WA 98195 USA

Kim, J:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

 Standigm Inc, Seoul 06250, South Korea

Kim, J:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

 Standigm Inc, Seoul 06250, South Korea

Kim, K:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

 Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

Kim, K:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

 Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

Kim, S:
 Korea Univ, Dept Comp Sci & Engn, Seoul 02841, South Korea

Kim, Y:
 Div Mol Carcinogenesis NKI, NL-1066 CX Amsterdam, Netherlands

 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

 Div Oncogen NKI, NL-1066 CX Amsterdam, Netherlands

Kim, Y:
 Div Mol Carcinogenesis NKI, NL-1066 CX Amsterdam, Netherlands

 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

 Div Oncogen NKI, NL-1066 CX Amsterdam, Netherlands

Kirk, PDW:
 Univ Cambridge, MRC Biostat Unit, Cambridge CB2 0SR, England

Kitano, H:
 Syst Biol Inst Tokyo, Tokyo 1410022, Japan

Klambauer, G:
 Johannes Kepler Univ Linz, Inst Machine Learning Johannes Kepler, A-4040 Linz, Austria

Knowles, D:
 Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

 Stanford Univ, Dept Genet, Stanford, CA 94305 USA

Ko, M:
 Stanford Univ, Dept Canc Biol, Stanford, CA 94305 USA

Kohn-Luque, A:
 Univ Oslo, Dept Biostat, Oslo Ctr Biostat & Epidemiol, N-0317 Oslo, Norway

Kooistra, AJ:
 AIMMS Vrije Univ, Div Med Chem, NL-1081 HZ Amsterdam, Netherlands

Kuenemann, MA:
 North Carolina State Univ, Dept Chem, Bioinformat Res Ctr, Raleigh, NC 27695 USA

Kuiper, M:
 Norwegian Univ Sci & Technol, N-7491 Trondheim, Norway

Kurz, C:
 Helmholtz Zentrum Munchen, Inst Hlth Econ & Hlth Care Management, D-85764 Neuherberg, Germany

Kwon, M:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

van Laarhoven, T:
 Radboud Univ Nijmegen, Data Sci, NL-6525 Nijmegen, Netherlands

Laegreid, A:
 Norwegian Univ Sci & Technol, N-7491 Trondheim, Norway

Lederer, S:
 Radboud Univ Nijmegen, Data Sci, NL-6525 Nijmegen, Netherlands

Lee, H:
 Korea Univ, Dept Comp Sci & Engn, Seoul 02841, South Korea

Lee, J:
 Univ Texas Southwestern Med Ctr Dallas, Dept Bioinformat, Dallas, TX 75390 USA

Lee, YW:
 Kongju Natl Univ, Dept Med Informat, Gongju 32588, South Korea

Leppaho, E:
 Aalto Univ, Dept Comp Sci, Espoo 02150, Finland

Lewis, R:
 Univ Cambridge, Ctr Mol Informat, Dept Chem, Cambridge CB2 1EW, England

Li, J:
 Case Western Univ, Cleveland, OH 44106 USA

Li, L:
 Ohio State Univ, Coll Med, Dept Biomed Informat, Columbus, OH 43210 USA

Liley, J:
 Univ Cambridge, Dept Med, Cambridge CB2 0SP, England

Lim, WK:
 Med Sch Singapore, Ctr Computat Biol Duke NUS, Singapore 169857, Singapore

 SingHlth Duke NUS Inst Precis Med Singapore, Singapore 169857, Singapore

Lin, C:
 Carnegie Mellon Univ, Pittsburgh, PA 15213 USA

Liu, YY:
 Yale Univ, New Haven, CT 06520 USA

Lopez, Y:
 RIKEN Japan, Ctr Integrat Med Sci, Kobe, Hyogo 6500047, Japan

 Tokyo Med & Dent Univ, Math Med Res Inst, Dept Med Sci, Tokyo 1133510, Japan

 CREST JST, Tokyo 1020076, Japan

Low, J:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Lysenko, A:
 RIKEN Japan, Ctr Integrat Med Sci, Kobe, Hyogo 6500047, Japan

Machado, D:
 Univ Minho, Ctr Biol Engn CEB, P-4710057 Braga, Portugal

Madhukar, N:
 Weill Cornell Med, New York, NY 10065 USA

De Maeyer, D:
 Univ Ghent, B-9000 Ghent, Belgium

Malpartida, AB:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Mamitsuka, H:
 Kyoto Univ, Inst Chem Res, Bioinformat Ctr, Kyoto 6110011, Japan

Marabita, F:
 Karolinska Inst, Dept Med, Unit Computat Med, Solna SciLifeLab,Ctr Mol Med, SE-17176 Solna, Sweden

Marchal, K:
 Univ Ghent, B-9000 Ghent, Belgium

Marttinen, P:
 Aalto Univ Finland, Dept Comp Sci, HIIT, Espoo 02150, Finland

Mason, D:
 Univ Cambridge, Ctr Mol Informat, Dept Chem, Cambridge CB2 1EW, England

Mazaheri, A:
 Karolinska Inst, Ctr Mol Med, SciLifeLab, Algorithm Dynam Lab,Unit Computat Med,Dept Med So, SE-17176 Solna, Sweden

Mehmood, A:
 Univ Turku, Turku 20500, Finland

Mehreen, A:
 Univ Helsinki, Helsinki 00100, Finland

Michaut, M:
 Div Mol Carcinogenesis NKI, NL-1066 CX Amsterdam, Netherlands

Miller, RA:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Mitsopoulos, C:
 Inst Canc Res, London SW3 6JB, England

Modos, D:
 Univ Cambridge, Ctr Mol Informat, Dept Chem, Cambridge CB2 1EW, England

Van Moerbeke, M:
 Interuniv Inst Bioinformat Brussels, B-1050 Ixelles, Belgium

Moo, K:
 Univ Washington, Seattle, WA 98195 USA

Motsinger-Reif, A:
 North Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA

Movva, R:
 Stanford Univ, Dept Genet, Stanford, CA 94305 USA

Muraru, S:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Muratov, E:
 Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

Mushthofa, M:
 Univ Ghent, Bogor Agr Univ, B-9000 Ghent, Belgium

Nagarajan, N:
 Genome Inst Singapore, Computat & Syst Biol, Singapore 138672, Singapore

Nakken, S:
 Univ Paul Sabatier, Inst Math Toulouse, F-31400 Toulouse, France

Nath, A:
 Univ Minnesota, Minneapolis, MN 55455 USA

Neuvial, P:
 Univ Paul Sabatier, Inst Math Toulouse, F-31400 Toulouse, France

Newton, R:
 Univ Cambridge, Cambridge CB2 8PQ, England

Ning, Z:
 Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17176 Stockholm, Sweden

De Niz, C:
 Texas Tech Univ, Lubbock, TX 79409 USA

Oliva, B:
 Univ Pompeu Fabra Barcelona, Dept Expt & Life Sci, Struct Bioinformat Grp GRIB IMIM, Catalonia 08041, Spain

Olsen, C:
 Interuniv Inst Bioinformat Brussels, B-1050 Ixelles, Belgium

 Univ Libre Bruxelles, Dept Informat, MLG, B-1050 Brussels, Belgium

Palmeri, A:
 Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Panesar, B:
 Univ Toronto, Toronto, ON M5S, Canada

Papadopoulos, S:
 CERTH ITI, GR-5700 Thessaloniki, Greece

Park, J:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

Park, S:
 Korea Univ, Dept Comp Sci & Engn, Seoul 02841, South Korea

 Kongju Natl Univ, Dept Med Informat, Gongju 32588, South Korea

Park, S:
 Korea Univ, Dept Comp Sci & Engn, Seoul 02841, South Korea

 Kongju Natl Univ, Dept Med Informat, Gongju 32588, South Korea

Pawitan, Y:
 Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17176 Stockholm, Sweden

Peluso, D:
 Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Pendyala, S:
 Harvard Univ, Cambridge, MA 02138 USA

Peng, J:
 Univ Illinois, Champaign, IL 61820 USA

Perfetto, L:
 Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Pirro, S:
 Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Plevritis, S:
 Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

Politi, R:
 Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

Poon, H:
 Microsoft Res Redmond, Redmond, WA 98052 USA

Porta, E:
 Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA 92037 USA

Prellner, I:
 Cambridge Rindge & Latin High Sch, Cambridge, MA 02138 USA

Preuer, K:
 Johannes Kepler Univ Linz, Inst Machine Learning Johannes Kepler, A-4040 Linz, Austria

Pujana, MA:
 Catalan Inst Oncol ICO, Barcelona 19908908, Spain

 Bellvitge Biomed Biomed Res Inst IDIBELL, Barcelona 19908908, Spain

Ramnarine, R:
 Univ Toronto, Toronto, ON M5S, Canada

Reid, JE:
 Univ Cambridge, MRC Biostat Unit, Cambridge CB2 0SR, England

Reyal, F:
 Inst Curie, RT2 Lab, F-75248 Paris, France

Richardson, S:
 Univ Cambridge, MRC Biostat Unit, Cambridge CB2 0SR, England

Ricketts, C:
 Weill Cornell Med, New York, NY 10065 USA

Rieswijk, L:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

 Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth, Berkeley, CA 94720 USA

Rocha, M:
 Univ Minho, Ctr Biol Engn CEB, P-4710057 Braga, Portugal

Rodriguez-Gonzalvez, C:
 Inst Canc Res, London SW3 6JB, England

Roell, K:
 North Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA

Rotroff, D:
 North Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA

de Ruiter, JR:
 Div Mol Carcinogenesis NKI, NL-1066 CX Amsterdam, Netherlands

 Div Mol Pathol NKI, NL-1066 CX Amsterdam, Netherlands

Rukawa, P:
 Univ Cambridge, Cambridge CB2 8PQ, England

Sadacca, B:
 Inst Curie, RT2 Lab, F-75248 Paris, France

Safikhani, Z:
 Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 2C1, Canada

Safitri, F:
 Kyungpook Natl Univ, Daegu 41566, South Korea

Sales-Pardo, M:
 Quim Univ Rovira & Virgili, Dept Engn, Tarragona 43007, Spain

Sauer, S:
 FOM Univ Appl Sci, D-45127 Essen, Germany

Schlichting, M:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Seoane, JA:
 Stanford Univ, Stanford, CA 94305 USA

:
 Catalan Inst Oncol ICO, Barcelona 19908908, Spain

 Bellvitge Biomed Biomed Res Inst IDIBELL, Barcelona 19908908, Spain

Shang, MM:
 Karolinska Inst, Dept Med, Unit Computat Med, Solna SciLifeLab,Ctr Mol Med, SE-17176 Solna, Sweden

Sharma, A:
 RIKEN Japan, Ctr Integrat Med Sci, Kobe, Hyogo 6500047, Japan

 Griffith Univ, Inst Integrated & Intelligent Syst, Mt Cravat, Qld 4111, Australia

 Univ South Pacific Fiji, Suva, Fiji

Sharma, H:
 Univ Toronto, Toronto, ON M5S, Canada

Shen, Y:
 Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA

Shiga, M:
 Gifu Univ, Dept Elect Elect & Comp Engn, Gifu 5011193, Japan

Shin, M:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

Shkedy, Z:
 Hasselt Univ Belgium, Ctr Stat, B-3590 Hasselt, Belgium

Shopsowitz, K:
 Univ British Columbia, Fac Med, Kelowna, BC V1Y 1T3, Canada

Sinai, S:
 Harvard Univ, Program Evolutionary Dynam, Cambridge, MA 02138 USA

Skola, D:
 Univ Calif San Diego, Bioinformat & Syst Biol Program, La Jolla, CA 92093 USA

Smirnov, P:
 Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 2C1, Canada

Soerensen, IF:
 Aarhus Univ, Ctr Quantitat Genet & Genom, Dept Biol & Genet, DK-8000 Aarhus, Denmark

Soerensen, P:
 Aarhus Univ, Ctr Quantitat Genet & Genom, Dept Biol & Genet, DK-8000 Aarhus, Denmark

Song, JH:
 Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea

Song, SO:
 Standigm Inc, Seoul 06250, South Korea

Soufan, O:
 Div Mol Carcinogenesis NKI, NL-1066 CX Amsterdam, Netherlands

Spitzmueller, A:
 Tech Univ Munich, D-80333 Munich, Germany

Steipe, B:
 Univ Toronto, Toronto, ON M5S, Canada

Suphavilai, C:
 Genome Inst Singapore, Computat & Syst Biol, Singapore 138672, Singapore

 Natl Univ Singapore, Dept Comp Sci, Singapore 117417, Singapore

Tamayo, SP:
 Katholieke Univ Leuven, B-3000 Leuven, Belgium

Tamborero, D:
 UPF, Res Unit Biomed Informat, Barcelona 08041, Spain

Tang, J:
 Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland

Tanoli, ZUR:
 Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland

Tarres-Deulofeu, M:
 Quim Univ Rovira & Virgili, Dept Engn, Tarragona 43007, Spain

Tegner, J:
 Karolinska Inst, Dept Med, Unit Computat Med, Solna SciLifeLab,Ctr Mol Med, SE-17176 Solna, Sweden

 KAUST, Biol & Environm Sci & Engn Div, Thuwal 23955, Saudi Arabia

Thommesen, L:
 Norwegian Univ Sci & Technol, N-7491 Trondheim, Norway

Tonekaboni, SAM:
 Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 2C1, Canada

Tran, H:
 Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA

De Troyer, E:
 Hasselt Univ Belgium, Ctr Stat, B-3590 Hasselt, Belgium

Truong, A:
 Sage Bionetworks, Seattle, WA 98121 USA

Tsunoda, T:
 RIKEN Japan, Ctr Integrat Med Sci, Kobe, Hyogo 6500047, Japan

 Tokyo Med & Dent Univ, Math Med Res Inst, Dept Med Sci, Tokyo 1133510, Japan

 CREST JST, Tokyo 1020076, Japan

Turu, G:
 Semmelweis Univ, Fac Med, Dept Physiol, H-1085 Budapest, Hungary

 Hungarian Acad Sci, Lab Mol Physiol, H-1085 Budapest, Hungary

 Semmelweis Univ MTA SE, H-1085 Budapest, Hungary

Tzeng, GY:
 Univ Toronto, Toronto, ON M5S, Canada

Verbeke, L:
 Univ Ghent, B-9000 Ghent, Belgium

Videla, S:
 Leloir Inst, C1405 BWE, Buenos Aires, DF, Argentina

Vis, D:
 Div Mol Carcinogenesis NKI, NL-1066 CX Amsterdam, Netherlands

Voronkov, A:
 Univ Paul Sabatier, Inst Math Toulouse, F-31400 Toulouse, France

Votis, K:
 CERTH ITI, GR-5700 Thessaloniki, Greece

Wang, A:
 Univ Toronto, Toronto, ON M5S, Canada

Wang, HQH:
 Chinese Acad Sci, Canc Hosp, Hefei 230031, Anhui, Peoples R China

Wang, PW:
 Carnegie Mellon Univ, Pittsburgh, PA 15213 USA

Wang, S:
 Univ Illinois, Champaign, IL 61820 USA

Wang, W:
 City Univ Hong Kong, Dept Biomed Sci, Hong Kong 999077, Peoples R China

Wang, XC:
 Yale Univ, New Haven, CT 06520 USA

Wang, X:
 City Univ Hong Kong, Dept Biomed Sci, Hong Kong 999077, Peoples R China

 Yale Univ, New Haven, CT 06520 USA

Wennerberg, K:
 Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland

Wernisch, L:
 Univ Cambridge, MRC Biostat Unit, Cambridge CB2 0SR, England

Wessels, L:
 Div Mol Carcinogenesis NKI, NL-1066 CX Amsterdam, Netherlands

 Delft Univ Technol, Fac EEMCS, NL-2628 CD Delft, Netherlands

 Canc Genom Netherlands, NL-3584 CG Utrecht, Netherlands

van Westen, GJP:
 Leiden Univ, Acad Ctr Drug Res, Drug Discovery & Safety Leiden, NL-2333 CC Leiden, Netherlands

Westerman, BA:
 Canc Ctr, Dept Neurosurg, NL-1012 WX Amsterdam, Netherlands

White, SR:
 Univ Cambridge, MRC Biostat Unit, Cambridge CB2 0SR, England

Willighagen, E:
 BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands

Wurdinger, T:
 Canc Ctr, Dept Neurosurg, NL-1012 WX Amsterdam, Netherlands

Xie, L:
 CUNY, Hunter Coll, Dept Comp Sci, New York, NY 10016 USA

 CUNY, Grad Ctr, New York, NY USA

Xie, SL:
 Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA

Xu, H:
 Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA

Yadav, B:
 Univ Helsinki, Dept Clin Chem & Hematol, Hematol Res Unit Helsinki, Helsinki 00029, Finland

Yau, C:
 Univ Birmingham, Inst Canc & Genom Sci, Birmingham B15 2SY, W Midlands, England

Yeerna, H:
 Univ Calif San Diego, San Diego, SD 92093 USA

Yin, JW:
 Karolinska Inst, Dept Med, Unit Computat Med, Solna SciLifeLab,Ctr Mol Med, SE-17176 Solna, Sweden

Yu, M:
 Korea Univ, Dept Comp Sci & Engn, Seoul 02841, South Korea

 Univ Calif San Diego, Bioinformat & Syst Biol Program, La Jolla, CA 92093 USA

Yu, M:
 Korea Univ, Dept Comp Sci & Engn, Seoul 02841, South Korea

 Univ Calif San Diego, Bioinformat & Syst Biol Program, La Jolla, CA 92093 USA

Yun, SJ:
 Standigm Inc, Seoul 06250, South Korea

Zakharov, A:
 NIH, Natl Ctr Advancing Translat Sci, Bldg 10, Bethesda, MD 20892 USA

Zamichos, A:
 CERTH ITI, GR-5700 Thessaloniki, Greece

Zanin, M:
 Univ Politecn Madrid, E-28040 Madrid, Spain

Zeng, L:
 Yale Univ, New Haven, CT 06520 USA

Zenil, H:
 Karolinska Inst, Ctr Mol Med, SciLifeLab, Algorithm Dynam Lab,Unit Computat Med,Dept Med So, SE-17176 Solna, Sweden

 Oxford Immune Algorithm Ltd, Oxford RG1 3EU, England

Zhang, F:
 Univ Toronto, Toronto, ON M5S, Canada

Zhang, PY:
 Indiana Univ Purdue Univ, Indianapolis, IN 47907 USA

Zhang, W:
 Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Zhao, HY:
 Yale Univ, New Haven, CT 06520 USA

Zhao, L:
 City Univ Hong Kong, Dept Elect Engn, Hong Kong 999077, Peoples R China

Zheng, WJ:
 Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA

Zoufir, A:
 Univ Cambridge, Ctr Mol Informat, Dept Chem, Cambridge CB2 1EW, England

Zucknick, M:
 Univ Oslo, Dept Biostat, Oslo Ctr Biostat & Epidemiol, N-0317 Oslo, Norway
ISSN: 20411723





Nature Communications
Editorial
Nature Publishing Group, HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY, Reino Unido
Tipo de documento: Article
Volumen: 10 Número:
Páginas:
WOS Id: 000471758500010
ID de PubMed: 31209238
imagen Green Accepted, Green Published, gold

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